P.2.133 Antidepressant drug combination from treatment initiation to improve therapeutic response in major depression

2005 ◽  
Vol 15 ◽  
pp. S449-S450 ◽  
Keyword(s):  
Major Depression ◽  
Drug Combination ◽  
Therapeutic Response ◽  
Treatment Initiation ◽  
Antidepressant Drug

Toward Optimal Treatments for Major Depression

CNS Spectrums ◽  
2002 ◽  
Vol 7 (2) ◽  
pp. 148-154 ◽  
Author(s):  
Pierre Blier ◽  
Herbert Ward
Keyword(s):  
Major Depression ◽  
Therapeutic Response ◽  
Antidepressant Drug ◽  
Treatment Resistant Depression ◽  
Antidepressant Response ◽  
Controlled Clinical Trials ◽  
Treatment Resistant ◽  
Ongoing Research ◽  
Resistant Depression ◽  
First And Second Generation

ABSTRACTThe treatment of major depression remains problematic for several reasons. In particular, the therapeutic response to medications usually does not manifest itself until a week after administration has begun, and more than half the patients will not experience a full recovery with the first antidepressant drug administration. There are, however, some pharmacologic strategies that can accelerate antidepressant response. When facing a treatment-resistant depression, combination therapy offers a more time-efficient approach to achieve remission than drug substitution. These interventions have been devised on a better understanding of the basis for the therapeutic response obtained with the first- and second-generation antidepressants, and evidence derived from controlled clinical trials of their superior effectiveness is growing. The rationale for such approaches will be described in this article, as well as their advantages and potential inconveniences. Ongoing research in this field continues to fuel the development of novel, better-tolerated, and more effective pharmacotherapies for depression.

Fenetyline as possible treatment in non-responder depressive patients

1990 ◽  
Vol 5 (1) ◽  
pp. 29-30
Author(s):  
F Lang ◽  
J Pellet ◽  
B Estour
Keyword(s):  
Major Depression ◽  
Sleep Deprivation ◽  
Therapeutic Response ◽  
Manic Episode ◽  
Endogenous Depression ◽  
Recurrent Depression ◽  
Different Types ◽  
Depressive Episodes ◽  
Depressive Patients

SummaryThe authors report the case of a 45-yr-old male who presented from 1979 to 1986 with several severe depressive episodes. The patient fulfilled Feighner criteria for major depression, Newcastle criteria for endogenous depression: the depressive episodes were all classified as severe recurrent depression without melancholia according to DSM III. The patient was resistant to different types of treatment (ECT, tricyclic and MAOI drugs, lithium, sleep deprivation). With a treatment of 10 cg/day of fenetyline, reduced to 5 cg/day after 6 months, (atypical manic episode), the patient improved considerably for 20 rnonths. The therapeutic response decreased after this period but after a month of withdrawal, the patient again responded. The authors cannot explain the duration of this therapeutic response.

Plasma 3,4-Dihydroxyphenylethyleneglycol and Therapeutic Response to Maprotiline and Indalpine in Major Depression

1986 ◽  
Vol 15 (2) ◽  
pp. 62-67 ◽  
Author(s):  
Henri Lôo ◽  
Chawki Benkelfat ◽  
Marie-France Poirier ◽  
Jean-Marie Vanelle ◽  
Jean-Pierre Olié ◽  
...  
Keyword(s):  
Major Depression ◽  
Therapeutic Response

The effect of commonly used antidepressant drug groups on sleep profile with major depression

2011 ◽  
Vol 18 (2) ◽  
pp. 57-64 ◽  
Author(s):  
Ismail Youseff ◽  
Abdel Rahman Hasan ◽  
Magda Fahmy ◽  
Tarek Assad ◽  
Ghada El-Khouly ◽  
...  
Keyword(s):  
Major Depression ◽  
Antidepressant Drug

scholarly journals Observational study of drug use pattern in indoor patients suffering from major depression admitted in psychiatry department of tertiary care teaching hospital

2018 ◽  
Vol 7 (9) ◽  
pp. 1808
Author(s):  
Vaishali Thakare ◽  
Lily Dubey
Keyword(s):  
Major Depression ◽  
Drug Use ◽  
Observational Study ◽  
Health Service Utilization ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Prospective Observational Study ◽  
Tertiary Care ◽  
Antidepressant Drug ◽  
Use Pattern ◽  
Drug Use Pattern

Background: Mental illness is associated with high levels of health service utilization and associated costs. India is among one of the countries with the highest number of people suffering from depression. The data on antidepressant drug utilization in India is sparse. Hence, we planned to analyse the drug use pattern in patients of major depression as per the WHO recommended indicators of drug use.Methods: This prospective observational study was done to analyze the prescription pattern of hospital psychiatrist in indoor major depression patients. All the patients admitted in psychiatry indoor patient department (I. P. D.) of Dr. D. Y. Patil Hospital, Navi Mumbai were included.Results: Data of 97 patients was analysed. 55.67% of the cases were from the age group 31-50 years. Total number of antidepressants prescribed was 102(36.82%). Out of antidepressant agents, Selective Serotonin Reuptake Inhibitors (SSRIs) were the most commonly prescribed drugs 70 (68.62%). The most commonly prescribed antidepressant was Sertraline in 35 (34.3%).Conclusions: The findings of our study were similar to those of other studies conducted to evaluate the use of antidepressants.

Urinary 3-methoxy, 4-hydroxyphenylethylene glycol and therapeutic response to maprotiline and indalpine in major depression

1986 ◽  
Vol 66 (1) ◽  
pp. 47-58
Author(s):  
H. Loo ◽  
C. Benkelfat ◽  
J. M. Vanelle ◽  
T. Dennis ◽  
M. F. Poirier ◽  
...  
Keyword(s):  
Major Depression ◽  
Therapeutic Response
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