20 BALANCE BETWEEN CIRCULATING ENDOTHELIAL PROGENITOR CELLS (EPCs) AND MATURE CIRCULATING ENDOTHELIAL CELLS (CECs) IN RELATION TO THE SEVERITY OF PERIPHERAL ARTERIAL DISEASE

2008 ◽  
Vol 18 ◽  
pp. S39-S40
Author(s):  
F. Cesari ◽  
F. Sofi ◽  
A.M. Gori ◽  
R. Caporale ◽  
M. Di Mare ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Peripheral Arterial Disease ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Arterial Disease ◽  
Circulating Endothelial Cells ◽  
Endothelial Progenitor ◽  
Circulating Endothelial Progenitor Cells ◽  
Peripheral Arterial

Endothelial Progenitor Cells and Their Potential Clinical Applications in Peripheral Arterial Disease

Endothelium ◽  
2005 ◽  
Vol 12 (5-6) ◽  
pp. 243-250 ◽  
Author(s):  
N. Alobaid ◽  
M. E. Alnaeb ◽  
K. M. Sales ◽  
A. M. Seifalian ◽  
D. P. Mikhailidis ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Arterial Disease ◽  
Clinical Applications ◽  
Endothelial Progenitor ◽  
Peripheral Arterial

scholarly journals Effect of Peptidylarginine Deiminase 4 on Endothelial Progenitor Cell Function in Peripheral Arterial Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Jialin Pan ◽  
Wenqin Liu ◽  
Ye Chen ◽  
Chi Zhang ◽  
Cong Lin
Keyword(s):  
Peripheral Arterial Disease ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Therapeutic Effect ◽  
Arterial Disease ◽  
Peptidylarginine Deiminase ◽  
Endothelial Progenitor ◽  
Hematopoietic Stem ◽  
Peripheral Arterial Diseases ◽  
Peripheral Arterial

At present, the global prevalence of peripheral arterial disease is increasing year by year, and it has become a worldwide disease. Studies have shown that transplanting endothelial progenitor cells (EPCs) into ischemic tissues can improve the tissue ischemia, thereby having a therapeutic effect on peripheral arterial diseases. This indicates that EPCs play a therapeutic effect in peripheral arterial disease. Recent studies have shown that peptidylarginine deiminase (PAD) is involved in the regulation of epigenetics and its inhibitor Cl-amidine can improve endothelium-dependent vasodilation and significantly reduce the formation of arterial thrombosis. It can also play a role in hematopoietic stem cells that share the same origin with EPCs. Therefore, we speculate that PAD4 may also have an effect on EPCs through a similar mechanism, thereby participating in the damage and repair of peripheral arterial disease. Therefore, we first detected the expression of PAD4 in EPCs of peripheral arterial disease and detected changes in the number and function of endothelial progenitor cells in peripheral blood after injecting the PAD4 inhibitor Cl-amidine into mice. A mouse model of lower limb ischemia was established to explore the effect of PAD4 on the function of EPCs in peripheral arterial disease. The results show that PAD4 is highly expressed in peripheral arterial diseases and the PAD4 inhibitor Cl-amidine can increase the number of EPCs and can treat peripheral arterial diseases by improving the proliferation, migration, and vascularization of EPCs.

Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells

Blood ◽  
2005 ◽  
Vol 106 (5) ◽  
pp. 1525-1531 ◽  
Author(s):  
David A. Ingram ◽  
Noel M. Caplice ◽  
Mervin C. Yoder
Keyword(s):  
Endothelial Cells ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Circulating Endothelial Cells ◽  
Proliferative Potential ◽  
Endothelial Progenitor ◽  
Detailed Understanding ◽  
Circulating Endothelial Progenitor Cells

Abstract The field of vascular biology has been stimulated by the concept that circulating endothelial progenitor cells (EPCs) may play a role in neoangiogenesis (postnatal vasculogenesis). One problem for the field has been the difficulty in accurately defining an EPC. Likewise, circulating endothelial cells (CECs) are not well defined. The lack of a detailed understanding of the proliferative potential of EPCs and CECs has contributed to the controversy in identifying these cells and understanding their biology in vitro or in vivo. A novel paradigm using proliferative potential as one defining aspect of EPC biology suggests that a hierarchy of EPCs exists in human blood and blood vessels. The potential implications of this view in relation to current EPC definitions are discussed.

scholarly journals Circulating Endothelial Cells, Circulating Endothelial Progenitor Cells, and Circulating Microparticles in Type 1 Diabetes Mellitus

2019 ◽  
Vol 25 ◽  
pp. 107602961882531 ◽  
Author(s):  
Asmaa M. Zahran ◽  
Ismail L. Mohamed ◽  
Osama M. El Asheer ◽  
Deiaaeldin M. Tamer ◽  
Mohamed G. M. Abo-ELela ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Type 1 Diabetes ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Circulating Endothelial Cells ◽  
Endothelial Progenitor ◽  
Circulating Endothelial Progenitor Cells ◽  
Diabetic Children ◽  
Circulating Microparticles

Background and Aim: Hyperglycemia in type 1 diabetes (T1D) is accompanied by endothelial cell dysfunction which is known to contribute to the pathogenesis of cardiovascular disorders. The aim of the current study was to explore the profile of circulating endothelial progenitor cells (EPCs), circulating endothelial cells (CECs), endothelial and platelet derived micropaticles (EMPs, PMPs) and total microparticles (TMPs), in T1D children in relation to each other and to the metabolic disorders accompanying T1D. Patients and Methods: Thirty T1D patients and 20 age and sex matched healthy volunteers were assessed for HbA1c level and lipid profile. Quantification of CECs, EPCs, TMPs, EMPs and PMPs was done by flow cytometry. Results: The mean levels of EMPs, PMPs, TMPs and CECs were significantly higher in diabetic children compared to controls. Meanwhile, the levels of EPCs were significantly lower in diabetic children compared to controls. Both PMPs and CECs showed the highest significant differences between patients and controls and their levels were directly related to HbA1c, total cholesterol, LDL and triglycerides. A moderate correlation was observed between the frequency of PMPs and CECs. EPCs revealed negative correlations with both LDL and triglycerides. TMPs were only related to LDL, while EMPs were only related to HbA1c. Conclusion: Although there is disturbance in the levels of EMPs, PMPs, TMPs, CECs and EPCs in type 1 diabetic children compared to the controls, only the levels of PMPs and CECs were closely affected by the poor glycemic control and dyslipidemia occurring in T1D; thus may contribute to a higher risk of cardiovascular diseases.

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