466 Benefit of Different Radiation Boost Dose Based on Surgical Margins – Single-institution Experience on 2 173 Patients Treated with Radiotherapy After Breast-conserving Surgery

2012 ◽  
Vol 48 ◽  
pp. S182-S183
Author(s):  
I. Meattini ◽  
L. Livi ◽  
C. Saieva ◽  
V. Scotti ◽  
D. Franceschini ◽  
...  
Keyword(s):  
Breast Conserving Surgery ◽  
Surgical Margins ◽  
Single Institution ◽  
Radiation Boost ◽  
Boost Dose

Pathologic Evaluation of Surgical Margins and Local Recurrences after Breast-conserving Surgery without Irradiation

2000 ◽  
Vol 24 (3) ◽  
pp. 328-333 ◽  
Author(s):  
Takao Kato ◽  
Tsunehito Kimura ◽  
Nobue Ishii ◽  
Akiho Fujii ◽  
Kazuko Yamamoto ◽  
...  
Keyword(s):  
Breast Conserving Surgery ◽  
Surgical Margins ◽  
Local Recurrences ◽  
Pathologic Evaluation

scholarly journals Advanced Oncoplastic Breast Conserving Surgery: Single Institution Experience with 823 Patients

Chirurgia ◽  
2021 ◽  
Vol 116 (200) ◽  
pp. S59
Author(s):  
Andrii Zhygulin ◽  
Artem Fedosov ◽  
Valentyn Palytsia ◽  
Daria Vinnytska ◽  
Vitalii Nedielchev ◽  
...  
Keyword(s):  
Breast Conserving Surgery ◽  
Single Institution

scholarly journals The approach to an isolated close anterior margin in breast conserving surgery

2019 ◽  
Vol 101 (4) ◽  
pp. 268-272
Author(s):  
L O’Connell ◽  
S Walsh ◽  
D Evoy ◽  
A O’Doherty ◽  
C Quinn ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Anterior Margin ◽  
Residual Disease ◽  
Breast Conserving Surgery ◽  
University Hospital ◽  
Single Institution ◽  
Close Margin ◽  
Patient Demographics ◽  
Included Patient ◽  
Tumour Characteristics

Introduction Although close radial margins after breast-conserving surgery routinely undergo re-excision, appropriate management of patients with close anterior margins remains a topic of controversy. An increasing body of literature suggests that re-excision of close anterior margins yields low rates of residual malignancy and may only be necessary in selected patients. The aim of this study was to examine the management of close anterior margins after breast conserving surgery in a single institution and to analyse the rate of residual disease in re-excised anterior margins. Methods All patients having breast conserving surgery at St Vincent’s University Hospital from January 2008 to December 2012 were reviewed retrospectively. Data collected included patient demographics, tumour characteristics, margin positivity, re-excision rates and definitive histology of the re-excision specimens. A close margin was defined as les than 2 mm. Results A total of 930 patients were included with an average age of 65 years (range 29–94 years). Of these, 121 (13%) had a close anterior margin. Further re-excison of the anterior margin was carried out in 37 patients (30.6%) and a further 16 (13.2%) proceeded to mastectomy. Residual disease was found in 18.5% (7/36) of those who underwent re-excision and 7/16 (43.75%) of those who underwent mastectomy. Overall, 11.57% (14/121) of patients with close anterior margins were subsequently found to have residual disease. Conclusion The low yield of residual disease in re-excised anterior margins specimens supports the concept that routine re-excision of close anterior margins is not necessary. Further research is required to definitively assess its influence on the risk of local recurrence.

A 12-Year Single-Institution Experience with Accelerated Partial Breast Irradiation

2018 ◽  
Vol 84 (8) ◽  
pp. 1261-1263
Author(s):  
Anthony M. Scott ◽  
Matthew C. Callier ◽  
Madison Lashley ◽  
David A. Cole ◽  
Paul S. Dale
Keyword(s):  
Skin Irritation ◽  
Breast Conserving Surgery ◽  
Accelerated Partial Breast Irradiation ◽  
Partial Breast Irradiation ◽  
Breast Irradiation ◽  
Single Institution ◽  
Recurrence Rates ◽  
Breast Brachytherapy ◽  
Skin Erythema ◽  
American Society

Accelerated partial breast irradiation (APBI) using the implanted brachytherapy device MammoSite® was approved for routine use by the Food and Drug Administration in 2002. The American Society of Breast Surgeons MammoSite® Breast Brachytherapy Registry served as a guideline for our institution to begin offering this treatment in 2005. This report reviews our available data to provide an analysis of patient outcomes over 12 years of use at a single institution. A retrospective review was conducted of records of 150 patients who underwent APBI or attempted APBI after breast-sparing surgeries between 2006 and 2017. These charts were analyzed for documentation of patient age, cancer stage, incidence of recurrence, and posttreatment complications. Of the patients evaluated, 99 per cent (149/150) completed treatment. The median time since treatment completion is now 8.9 years. One hundred eleven patients (74%) are now greater than five years posttreatment. Ipsilateral breast recurrence was found in 2.7 per cent of patients (4/149), and 1.3 per cent of patients (2/149) developed new primary breast tumors. Acute complications, mostly skin erythema (21%), were uncommon and self-limited. Subacute effects were generally fibrosis (13%) and mild local pain (9.4%). APBI for breast cancer after breast-conserving surgery continues to be used at our institution for select patients with good outcomes. Local control and toxicity are similar to that reported in the literature. Five-year local recurrence rates compare favorably with national trials. Occasional complications included fibrosis, persistent pain, and skin irritation.

Incidence of local recurrence in patients after breast-conserving surgery and postoperative radiotherapy with or without a supplementary radiation.

2012 ◽  
Vol 30 (27_suppl) ◽  
pp. 159-159
Author(s):  
Danijela D. Scepanovic ◽  
Andrea Hurakova ◽  
Martina Lukacovicova ◽  
Zuzana Dolinska ◽  
Andrea Masarykova ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Significant Influence ◽  
Postoperative Radiotherapy ◽  
Local Treatment ◽  
Breast Conserving Surgery ◽  
Low Risk ◽  
Surgical Margins ◽  
Complete Excision ◽  
Incomplete Excision ◽  
Significant Difference

159 Background: We evaluated the incidence of local recurrence (LR) among patients (pts) who received radiotherapy with/without a supplementary dose of radiation (boost) to the tumor bed after breast-conserving surgery (BCS) for early breast cancer (BC). Methods: In our retrospective analysis (from 2000-2004) 449 pts with stage I/II BC received 50Gy of radiation to the whole breast in 2Gy fractions over a five-week period after BCS. There were 328 pts (73%) with microscopically complete excision (>5mm margins) and 121 pts (27%) with a microscopically incomplete excision (≤5mm margins). Patients with a microscopically complete or incomplete excision were randomly assigned to receive either no further local treatment (190) or an additional localized dose (309) of 10-16Gy, usually given in 5-8 fractions (fr) by electrons/15Gy in 3 fr by HDR interstitial brachytherapy. Results: During a median follow-up period of 79 months (min 20, max 120), the cumulative incidence of LR was 3% for all group of pts (449). The LR was observed in 1 of 190 pts in group without boost and 13 of 309 pts in group with boost. There was statistically significant difference between two groups of pts regarding local recurrence rate (LRR) (p= 0.0218).The 5 year actuarial rates of LR were 1% in group of pts with negative surgical margins versus 8% in group of pts with positive margins [95% CI, 6% (1%-26%)] (p<0.001). Multivariate analysis showed that pts with negative surgical margins had strongly statistically significant influence (p<0.001) and pts with negative lymph/angioinvasion had statistically significant influence on low risk of LR (p = 0.007). The 5 year DFS was 90% and OS was 98% in all group of pts (449). There was no statistical significant difference between two groups of pts regarding DFS and OS. Conclusions: In our analysis, the incidence of LR is low. However, there was better result in no boost group of pts regarding LRR. The cause was in more frequent selection among worse group of pts with positive surgical margins for application of boost (73% vs 52%, p<0.0001). The strong criteria for identifying low risk group of pts for LR were: negative surgical margins and absence of lymph/angioinvasion.

Sign in / Sign up

Export Citation Format

Share Document