Pathologic Evaluation of Surgical Margins and Local Recurrences after Breast-conserving Surgery without Irradiation

2000 ◽  
Vol 24 (3) ◽  
pp. 328-333 ◽  
Author(s):  
Takao Kato ◽  
Tsunehito Kimura ◽  
Nobue Ishii ◽  
Akiho Fujii ◽  
Kazuko Yamamoto ◽  
...  
Keyword(s):  
Breast Conserving Surgery ◽  
Surgical Margins ◽  
Local Recurrences ◽  
Pathologic Evaluation

Local recurrences and distant metastases after breast-conserving surgery and radiation therapy for early breast cancer

1999 ◽  
Vol 43 (1) ◽  
pp. 25-38 ◽  
Author(s):  
Emmanuel Touboul ◽  
Laurent Buffat ◽  
Yazid Belkacémi ◽  
Jean-Pierre Lefranc ◽  
Serge Uzan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Early Breast Cancer ◽  
Distant Metastases ◽  
Breast Conserving Surgery ◽  
Local Recurrences

466 Benefit of Different Radiation Boost Dose Based on Surgical Margins – Single-institution Experience on 2 173 Patients Treated with Radiotherapy After Breast-conserving Surgery

2012 ◽  
Vol 48 ◽  
pp. S182-S183
Author(s):  
I. Meattini ◽  
L. Livi ◽  
C. Saieva ◽  
V. Scotti ◽  
D. Franceschini ◽  
...  
Keyword(s):  
Breast Conserving Surgery ◽  
Surgical Margins ◽  
Single Institution ◽  
Radiation Boost ◽  
Boost Dose

Incidence of local recurrence in patients after breast-conserving surgery and postoperative radiotherapy with or without a supplementary radiation.

2012 ◽  
Vol 30 (27_suppl) ◽  
pp. 159-159
Author(s):  
Danijela D. Scepanovic ◽  
Andrea Hurakova ◽  
Martina Lukacovicova ◽  
Zuzana Dolinska ◽  
Andrea Masarykova ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Significant Influence ◽  
Postoperative Radiotherapy ◽  
Local Treatment ◽  
Breast Conserving Surgery ◽  
Low Risk ◽  
Surgical Margins ◽  
Complete Excision ◽  
Incomplete Excision ◽  
Significant Difference

159 Background: We evaluated the incidence of local recurrence (LR) among patients (pts) who received radiotherapy with/without a supplementary dose of radiation (boost) to the tumor bed after breast-conserving surgery (BCS) for early breast cancer (BC). Methods: In our retrospective analysis (from 2000-2004) 449 pts with stage I/II BC received 50Gy of radiation to the whole breast in 2Gy fractions over a five-week period after BCS. There were 328 pts (73%) with microscopically complete excision (>5mm margins) and 121 pts (27%) with a microscopically incomplete excision (≤5mm margins). Patients with a microscopically complete or incomplete excision were randomly assigned to receive either no further local treatment (190) or an additional localized dose (309) of 10-16Gy, usually given in 5-8 fractions (fr) by electrons/15Gy in 3 fr by HDR interstitial brachytherapy. Results: During a median follow-up period of 79 months (min 20, max 120), the cumulative incidence of LR was 3% for all group of pts (449). The LR was observed in 1 of 190 pts in group without boost and 13 of 309 pts in group with boost. There was statistically significant difference between two groups of pts regarding local recurrence rate (LRR) (p= 0.0218).The 5 year actuarial rates of LR were 1% in group of pts with negative surgical margins versus 8% in group of pts with positive margins [95% CI, 6% (1%-26%)] (p<0.001). Multivariate analysis showed that pts with negative surgical margins had strongly statistically significant influence (p<0.001) and pts with negative lymph/angioinvasion had statistically significant influence on low risk of LR (p = 0.007). The 5 year DFS was 90% and OS was 98% in all group of pts (449). There was no statistical significant difference between two groups of pts regarding DFS and OS. Conclusions: In our analysis, the incidence of LR is low. However, there was better result in no boost group of pts regarding LRR. The cause was in more frequent selection among worse group of pts with positive surgical margins for application of boost (73% vs 52%, p<0.0001). The strong criteria for identifying low risk group of pts for LR were: negative surgical margins and absence of lymph/angioinvasion.

Lack of definitive presurgical pathological diagnosis is associated with inadequate surgical margins in breast-conserving surgery

2021 ◽  
Author(s):  
Paola V. Nasute Fauerbach ◽  
Kathrin Tyryshkin ◽  
Silvia Perez Rodrigo ◽  
John Rudan ◽  
Gabor Fichtinger ◽  
...  
Keyword(s):  
Breast Conserving Surgery ◽  
Surgical Margins ◽  
Pathological Diagnosis

Optimal margins: A retrospective analysis of surgical margins in patients who underwent breast-conserving surgery prior to the release of the 2014 SSO/ASTRO consensus guidelines

2015 ◽  
Vol 137 ◽  
pp. 138
Author(s):  
L.K. Berry ◽  
K.L. Wang ◽  
S.L. Galvin ◽  
A.B. Parlier ◽  
C.B. Harkness ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Breast Conserving Surgery ◽  
Surgical Margins ◽  
Consensus Guidelines

The reliability of specimen X-rays in assessing surgical margins in breast conserving surgery

2017 ◽  
Vol 43 (5) ◽  
pp. S55
Author(s):  
Hannah Dunlop ◽  
Laszlo Romics ◽  
Sheila Stallard ◽  
Tom York
Keyword(s):  
Breast Conserving Surgery ◽  
Surgical Margins ◽  
X Rays

scholarly journals Intraoperative assessment of surgical margins during breast conserving surgery of ductal carcinoma in situ by use of radiofrequency spectroscopy

The Breast ◽  
2011 ◽  
Vol 20 (6) ◽  
pp. 579-580 ◽  
Author(s):  
Marc Thill ◽  
Kathrin Röder ◽  
Klaus Diedrich ◽  
Christine Dittmer
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Breast Conserving Surgery ◽  
Surgical Margins ◽  
Intraoperative Assessment

scholarly journals True Local Recurrences or New Primary Tumors after Breast-Conserving Surgery and Radiation Therapy

2007 ◽  
Vol 57 (3) ◽  
pp. 221-224
Author(s):  
Jun Horiguchi ◽  
Yukio Koibuchi ◽  
Nana Rokutanda ◽  
Rin Nagaoka ◽  
Yuko Ishikawa ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Breast Conserving Surgery ◽  
Primary Tumors ◽  
Local Recurrences

scholarly journals The impact of atypical hyperplasia at the margins of breast-conserving surgery on the outcomes of breast cancer in patients treated with neoadjuvant chemotherapy

2021 ◽  
Author(s):  
Heran Deng ◽  
Jing Zhang ◽  
Tingting Hu ◽  
Qian Li ◽  
Yaping Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Ipsilateral Breast Tumor Recurrence ◽  
Breast Conserving Surgery ◽  
Atypical Hyperplasia ◽  
Surgical Margins ◽  
Breast Cancer Patients ◽  
Ipsilateral Breast ◽  
Free Survival ◽  
The Impact

Purpose Women with atypical hyperplasia (AH) is associated with a higher risk of later breast cancer. However, whether AH found at margins in patients with breast-conserving surgery (BCS) and neoadjuvant chemotherapy (NAC) needs re-excision is not well-defined. The aim of the present study was to evaluate the impact of atypical hyperplasia at the surgical margins on the local recurrence and survival outcomes in breast cancer patients treated with NAC and BCS. Methods A retrospective analysis comparing patients who received NAC with AH and received no re-excision to those without AH at the margins of BCS was performed. Results 323 patients were included in this study. The 5-year rates of ipsilateral breast tumor recurrence (IBTR) were 6% and 4.5% in patients with and without AH, respectively. Distant-metastasis-free survival (DMFS) at 5 years was 81.2% in the AH group, and 88.1% in the no-AH group. No significant differences were observed among the two groups in terms of IBTR, DMFS, or OS. Conclusion Our study suggests that AH involved at the surgical margins of BCS in patients who received NAC does not increase the risk of ipsilateral breast cancer, and there is insufficient evidence for surgeon to further resect AH found at the margins of BCS in these patients.

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