368 NP137, the first humanized monoclonal antibody directed against netrin-1, exhibits antitumor activity by inducing dependence receptors-mediated cell death

Dependence Receptors

Abstract 2517: Potent antitumor activity of AbGn-ADC, a humanized monoclonal antibody conjugated with dolastatin analogue, to gastric and pancreatic cancers expressing AbGn carbohydrate epitope

10.1158/1538-7445.am2012-2517 ◽

2012 ◽

Author(s):

Chiu-Chen Huang ◽

Yu-Chi Hsieh ◽

Yu-Ying Tsai ◽

Shu-Hua Lee ◽

Evelyn Chiang ◽

...

Keyword(s):

Monoclonal Antibody ◽

Antitumor Activity ◽

Carbohydrate Epitope ◽

Pancreatic Cancers ◽

The Anti–Human Leukocyte Antigen-DR Monoclonal Antibody 1D09C3 Activates the Mitochondrial Cell Death Pathway and Exerts a Potent Antitumor Activity in Lymphoma-Bearing Nonobese Diabetic/Severe Combined Immunodeficient Mice

Cancer Research ◽

10.1158/0008-5472.can-05-1200 ◽

2006 ◽

Vol 66 (3) ◽

pp. 1799-1808 ◽

Cited By ~ 36

Author(s):

Carmelo Carlo-Stella ◽

Massimo Di Nicola ◽

Maria Caterina Turco ◽

Loredana Cleris ◽

Cristiana Lavazza ◽

...

Keyword(s):

Monoclonal Antibody ◽

Cell Death ◽

Antitumor Activity ◽

Human Leukocyte Antigen ◽

Human Leukocyte ◽

Immunodeficient Mice ◽

Leukocyte Antigen ◽

Nonobese Diabetic ◽

Cell Death Pathway

A phase II, randomized, open-label study evaluating the antitumor activity of MEDI-522, a humanized monoclonal antibody directed against the human alpha v beta 3 (avb3) integrin, ± dacarbazine (DTIC) in patients with metastatic melanoma (MM)

Journal of Clinical Oncology ◽

10.1200/jco.2005.23.16_suppl.7507 ◽

2005 ◽

Vol 23 (16_suppl) ◽

pp. 7507-7507 ◽

Cited By ~ 27

Author(s):

P. Hersey ◽

J. Sosman ◽

S. O’Day ◽

J. Richards ◽

A. Bedikian ◽

...

Keyword(s):

Monoclonal Antibody ◽

Antitumor Activity ◽

Metastatic Melanoma ◽

Phase Ii ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Alpha V Beta 3

A phase Ib dose-escalation study of the safety, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of the humanized monoclonal antibody (huMAb) anti-EGFL7 (MEGF0444A) in combination with bevacizumab with or without paclitaxel in patients with advanced solid tumors.

Journal of Clinical Oncology ◽

10.1200/jco.2011.29.15_suppl.2514 ◽

2011 ◽

Vol 29 (15_suppl) ◽

pp. 2514-2514 ◽

Cited By ~ 4

Author(s):

L. Naumovski ◽

M. S. Gordon ◽

P. N. Munster ◽

P. Hegde ◽

J. Fredrickson ◽

...

Keyword(s):

Monoclonal Antibody ◽

Antitumor Activity ◽

Solid Tumors ◽

Dose Escalation ◽

Advanced Solid Tumors ◽

Dose Escalation Study ◽

Phase Ib ◽

Abstract 2921: Preclinical characteristics of NP137, a first-in-class monoclonal antibody directed against netrin-1 and inducing dependence receptors-mediated cell death

10.1158/1538-7445.am2015-2921 ◽

2015 ◽

Author(s):

Benjamen Ducarouge ◽

Jean-Guy Delcros ◽

Riad Abès ◽

David Goldschneider ◽

Benjamin Gibert ◽

...

Keyword(s):

Monoclonal Antibody ◽

Cell Death ◽

Dependence Receptors

Abstract 2009: Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular invasion and enhances cell death induced by DNA damaging chemotherapies

10.1158/1538-7445.am2019-2009 ◽

2019 ◽

Author(s):

Xuanmao Jiao ◽

Min Wang ◽

Richard G. Pestell

Keyword(s):

Breast Cancer ◽

Monoclonal Antibody ◽

Cell Death ◽

Cellular Invasion ◽

Antitumor activity of humanized monoclonal antibody against HM1.24 antigen in human myeloma xenograft models

Oncology Reports ◽

10.3892/or.15.2.361 ◽

2006 ◽

Cited By ~ 2

Author(s):

Shigeto Kawai ◽

Yasushi Yoshimura ◽

Shin-ichiro Iida ◽

Yasuko Kinoshita ◽

Yasuo Koishihara ◽

...

Keyword(s):

Monoclonal Antibody ◽

Antitumor Activity ◽

Xenograft Models

Abstract 2009: Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular invasion and enhances cell death induced by DNA damaging chemotherapies

10.1158/1538-7445.sabcs18-2009 ◽

2019 ◽

Author(s):

Xuanmao Jiao ◽

Min Wang ◽

Richard G. Pestell

Keyword(s):

Breast Cancer ◽

Monoclonal Antibody ◽

Cell Death ◽

Cellular Invasion ◽

A Phase II, Randomized, Open-Label Study Evaluating the Antitumor Activity of MEDI-522, A Humanized Monoclonal Antibody Directed Against the Human Alpha v Beta 3 (avb3) Integrin, ??Dacarbazine (DTIC) in Patients With Metastatic Melanoma (MM)

Journal of Immunotherapy ◽

10.1097/01.cji.0000191048.99060.8c ◽

2005 ◽

Vol 28 (6) ◽

pp. 643-644 ◽

Cited By ~ 2

Author(s):

P Hersey ◽

J Sosman ◽

S O??Day ◽

J Richards ◽

A Bedikian ◽

...

Keyword(s):

Monoclonal Antibody ◽

Antitumor Activity ◽

Metastatic Melanoma ◽

Phase Ii ◽

Open Label ◽

Open Label Study ◽

Label Study ◽

Alpha V Beta 3

Abstract PD4-04: Leronlimab, a humanized monoclonal antibody to CCR5, restrains breast cancer metastasis and enhances cell death induced by DNA damaging chemotherapies

10.1158/1538-7445.sabcs19-pd4-04 ◽

2020 ◽

Author(s):

Richard G Pestell ◽

Massimo Cristofanilli ◽

Hallgeir Rui ◽

Xuanmao Jiao ◽

Min Wang

Keyword(s):

Breast Cancer ◽

Monoclonal Antibody ◽

Cell Death ◽

Cancer Metastasis ◽

Breast Cancer Metastasis ◽