Codon 325 sequence polymorphism of the estrogen receptor α gene and bone mineral density in postmenopausal women

2001 ◽  
Vol 78 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Sanja Jurada ◽  
Janja Marc ◽  
Janez Preželj ◽  
Andreja Kocijančič ◽  
Radovan Komel
Keyword(s):  
Bone Mineral Density ◽  
Estrogen Receptor ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Estrogen Receptor Α ◽  
Sequence Polymorphism ◽  
Mineral Density ◽  
Estrogen Receptor Α Gene

Estrogen Receptor α Gene Polymorphisms and Bone Mineral Density in Healthy Children and Young Adults

2004 ◽  
Vol 74 (6) ◽  
pp. 495-500 ◽  
Author(s):  
A. M. Boot ◽  
I. M. van der Sluis ◽  
S. M. P. F. de Muinck Keizer-Schrama ◽  
J. B. J. van Meurs ◽  
E. P. Krenning ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Estrogen Receptor ◽  
Young Adults ◽  
Bone Mineral ◽  
Gene Polymorphisms ◽  
Estrogen Receptor Α ◽  
Healthy Children ◽  
Mineral Density ◽  
Children And Young Adults ◽  
Estrogen Receptor Α Gene

scholarly journals Association of Polymorphisms of the Estrogen Receptor α Gene With Bone Mineral Density and Fracture Risk in Women: A Meta-Analysis

2002 ◽  
Vol 17 (11) ◽  
pp. 2048-2060 ◽  
Author(s):  
John P. A. Ioannidis ◽  
Ioanna Stavrou ◽  
Thomas A. Trikalinos ◽  
Christos Zois ◽  
Maria Luisa Brandi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Estrogen Receptor ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Meta Analysis ◽  
Estrogen Receptor Α ◽  
Mineral Density ◽  
Estrogen Receptor Α Gene

Test of linkage and/or association between the estrogen receptor α gene with bone mineral density in Caucasian nuclear families

Bone ◽  
2004 ◽  
Vol 35 (2) ◽  
pp. 395-402 ◽  
Author(s):  
Lan-Juan Zhao ◽  
Peng-Yuan Liu ◽  
Ji-Rong Long ◽  
Yan Lu ◽  
Fu-Hua Xu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Estrogen Receptor ◽  
Bone Mineral ◽  
Estrogen Receptor Α ◽  
Mineral Density ◽  
Nuclear Families ◽  
Estrogen Receptor Α Gene

Effect of estrogenic compounds (estrogen or phytoestrogens) combined with exercise on bone and muscle mass in older individuals

2008 ◽  
Vol 33 (1) ◽  
pp. 200-212 ◽  
Author(s):  
Philip D. Chilibeck ◽  
Stephen M. Cornish
Keyword(s):  
Bone Mineral Density ◽  
Estrogen Receptor ◽  
Exercise Training ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Estrogen Therapy ◽  
Estrogen Receptor Α ◽  
Soy Isoflavones ◽  
Older Individuals ◽  
Mineral Density

Exercise has a beneficial effect on bone, possibly by stimulating estrogen receptor α. Because estrogen up-regulates this receptor, estrogen therapy combined with exercise training may be optimal for increasing bone mineral density. Studies combining estrogen therapy and exercise training in postmenopausal women show mixed results, but indicate that the combination of interventions may be more effective for increasing bone mass than either intervention alone. Plant-like estrogens (i.e phytoestrogens such as soy isoflavones) may act as weak estrogen agonists or antagonists, have small beneficial effects on bone, and may interact with exercise for increasing bone mineral density. Phytoestrogen derived from flaxseed (flax lignans) has not been evaluated as extensively as soy isoflavones and thus its effect on bone is difficult to determine. Estrogen or soy isoflavones given to postmenopausal women results in a small increase in lean tissue mass that may be mediated through estrogen receptor α on muscle or through decreased inflammation.

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