scholarly journals PO43 Study of two different dose fractionation schedules of post mastectomy chest wall irradiation in carcinoma breast patients

The Breast ◽  
2012 ◽  
Vol 21 ◽  
pp. S15
Author(s):  
P. Kumbhaj ◽  
R. Sharma ◽  
D.P. Singh ◽  
O.P. Sharma ◽  
A.R. Bhatnagar
Keyword(s):  
Chest Wall ◽  
Dose Fractionation ◽  
Carcinoma Breast ◽  
Fractionation Schedules

Sarcomas of soft tissue and bone

2019 ◽  
pp. 454-467
Author(s):  
James Wylie
Keyword(s):  
Soft Tissue ◽  
Chest Wall ◽  
Palliative Treatment ◽  
Soft Tissue Sarcomas ◽  
Dose Fractionation ◽  
Target Definition ◽  
Patient Preparation ◽  
Radiotherapy Techniques ◽  
Hands And Feet

Chapter 20 covers sarcomas of soft tissue and bone and includes discussion of radiotherapy for soft tissue sarcomas (including indications for radiotherapy, essential investigations for planning radiotherapy, patient preparation, planning imaging required for target definition, target definition, dose fractionation, and critical organs and tolerance doses,including the sites forearm, hands and feet, retroperitoneum, chest wall, and spinal/para-spinal), particular histologies (angiosarcoma and fibromatosis), particular radiotherapy techniques, and palliative treatment (including cerebral and lung secondaries),

scholarly journals Prostate SBRT: Comparison the Efficacy and Toxicity of Two Different Dose Fractionation Schedules

2020 ◽  
Vol 10 ◽  
Author(s):  
Donald Blake Fuller ◽  
John Naitoh ◽  
Reza Shirazi ◽  
Tami Crabtree ◽  
George Mardirossian
Keyword(s):  
Dose Fractionation ◽  
Fractionation Schedules

scholarly journals A Rare Presentation of Nodular Growth over Right Anterior Chest Wall in an Elderly Male Mimicking Carcinoma Breast

JMS SKIMS ◽  
2010 ◽  
Vol 13 (2) ◽  
pp. 70-71
Author(s):  
R K Maurya ◽  
Pawan Kumar Singh ◽  
Vivek Garg
Keyword(s):  
Breast Carcinoma ◽  
Chest Wall ◽  
Anterior Chest Wall ◽  
Elderly Male ◽  
Rare Presentation ◽  
Carcinoma Breast ◽  
Nodular Growth

Malignant malenoma in chest wall are rare, although reported. We hereby report a 60 year male who presented with nodular growth over anterior chest wall mimicking breast carcinoma. JMS 2010;13(2):70-71

SU-FF-T-330: Optimal Dose Fractionation Schedules Computed with Different Tumor Reoxygenation Rates

2007 ◽  
Vol 34 (6Part12) ◽  
pp. 2477-2477
Author(s):  
A Chvetsov ◽  
D Siemann ◽  
W Mendenhall ◽  
J Palta
Keyword(s):  
Optimal Dose ◽  
Dose Fractionation ◽  
Fractionation Schedules

scholarly journals Pharmacodynamics of Fluconazole in a Murine Model of Systemic Candidiasis

1998 ◽  
Vol 42 (5) ◽  
pp. 1105-1109 ◽  
Author(s):  
Arnold Louie ◽  
George L. Drusano ◽  
Partha Banerjee ◽  
Qing-Feng Liu ◽  
Weiguo Liu ◽  
...  
Keyword(s):  
Total Dose ◽  
Murine Model ◽  
Dose Fractionation ◽  
Maximal Effect ◽  
Systemic Candidiasis ◽  
Pharmacodynamic Parameter ◽  
Dose Response Relationship ◽  
Time Curve ◽  
Dose Ranging ◽  
Fractionation Schedules

ABSTRACT In this study we defined the pharmacodynamic parameter that optimizes outcome in deep-seated Candida albicansinfections treated with fluconazole. Using a murine model of systemic candidiasis, we conducted single-dose dose-ranging studies with fluconazole to determine the dosage of this drug that resulted in a 50% reduction in fungal densities (50% effective dose [ED50]) in kidneys versus the fungal densities in the kidneys of untreated controls. We found that the ED50 of fluconazole given intraperitoneally was 4.56 mg/kg of body weight/day (95% confidence interval, 3.60 to 5.53 mg/kg/day), and the dose-response relationship was best described by an inhibitory sigmoid maximal effect (E max) curve. To define the pharmacodynamics of fluconazole, we gave dosages lower than, approximating, and higher than the ED50 of fluconazole (range, 3.5 to 5.5 mg/kg/day, equivalent to the ED16 to the ED75) to various groups of infected animals using three dose-fractionation schedules. For each total dose of fluconazole examined, the dose-fractionation schedules optimized the ratio of the area under the concentration-time curve (AUC) to the MIC (the AUC/MIC ratio), the ratio of the maximum concentration of drug in serum (C max) to the MIC, and the time that the drug remained above the MIC for the infecting C. albicansisolate. Similar reductions in fungal densities in kidneys were seen between groups that received the same total dose of fluconazole in one, two, or four equally divided doses. Thus, dose-fractionation studies demonstrated that the pharmacodynamic parameter of fluconazole that best predicted outcome was the AUC/MIC ratio.

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