Synthesis and antitumor activity of duocarmycin derivatives: modification at C-8 position of A-ring pyrrole compounds bearing the simplified DNA-binding groups

2000 ◽  
Vol 8 (2) ◽  
pp. 381-391 ◽  
Author(s):  
Nobuyoshi Amishiro ◽  
Satoru Nagamura ◽  
Chikara Murakata ◽  
Akihiko Okamoto ◽  
Eiji Kobayashi ◽  
...  
Keyword(s):  
Dna Binding ◽  
Antitumor Activity

The intercalative DNA binding and antitumor activity of some Bis-acridines related to nitracrine

1985 ◽  
Vol 53 ◽  
pp. 371-375 ◽  
Author(s):  
R.M. Acheson ◽  
G.N. Taylor ◽  
M.J. Waring ◽  
S. Haylock ◽  
G. Abel
Keyword(s):  
Dna Binding ◽  
Antitumor Activity

Unexpected structure of enaminone Pd(II) complex in comparison with Cu(II) complex: Synthesis, characterization, DNA binding and antitumor activity

2021 ◽  
Vol 516 ◽  
pp. 120117
Author(s):  
Hoda A. El-Ghamry ◽  
Kosei Yamauchi ◽  
Ken Sakai ◽  
Thoraya A. Farghaly
Keyword(s):  
Dna Binding ◽  
Antitumor Activity

A New Samarium(III) Complex of Liriodenine: Synthesis, Crystal Structure, Antitumor Activity, and DNA Binding Study

2019 ◽  
Vol 645 (6-7) ◽  
pp. 570-579 ◽  
Author(s):  
Zhichun Bao ◽  
Delin Lai ◽  
Pengchang Shen ◽  
Mengxin Yu ◽  
Rajesh Kumar ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dna Binding ◽  
Antitumor Activity ◽  
Binding Study

One-step synthesis of methylene-bridged bis-carbazole and evaluation of its antitumor activity and G-quadruplex DNA binding property

2019 ◽  
Vol 90 ◽  
pp. 103074
Author(s):  
Gang Li ◽  
Haodong Tang ◽  
Chuanfeng Liu ◽  
Xiaoyu Liao ◽  
Sicong Li ◽  
...  
Keyword(s):  
Dna Binding ◽  
Antitumor Activity ◽  
Binding Property ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Dna Binding Property ◽  
One Step

Cytotoxicity, DNA binding and cell apoptosis induction of a zinc(ii) complex of HBrQ

MedChemComm ◽  
2015 ◽  
Vol 6 (12) ◽  
pp. 2224-2231 ◽  
Author(s):  
Hai-Rong Zhang ◽  
Yan-Cheng Liu ◽  
Ting Meng ◽  
Qi-Pin Qin ◽  
Shang-Feng Tang ◽  
...  
Keyword(s):  
Dna Binding ◽  
Antitumor Activity ◽  
Cell Apoptosis ◽  
Antitumor Effect ◽  
Apoptosis Induction ◽  
Mitochondria Dysfunction ◽  
Phase Arrest ◽  
Caspase Cascade

A zinc(ii) complex of HBrQ showed higher in vitro antitumor activity. It induced cell apoptosis in BEL-7404 cells via G2 phase arrest, led to mitochondria dysfunction and activation of caspase cascade. The central zinc(ii) should play a key role to enhance the antitumor effect

Antitumor Activity, X-ray Crystal Structure, and DNA Binding Properties of Thiocoraline A, a Natural Bisintercalating Thiodepsipeptide

2007 ◽  
Vol 50 (14) ◽  
pp. 3322-3333 ◽  
Author(s):  
Ana Negri ◽  
Esther Marco ◽  
Verónica García-Hernández ◽  
Alberto Domingo ◽  
Antonio L. Llamas-Saiz ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dna Binding ◽  
Antitumor Activity ◽  
Binding Properties ◽  
X Ray ◽  
Dna Binding Properties
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