Tc(V)-DMS tumor localization mechanism: a pH-sensitive Tc(V)-DMS—enhanced target/nontarget ratio by glucose-mediated acidosis

1998 ◽  
Vol 25 (6) ◽  
pp. 549-555 ◽  
Author(s):  
Kazuko Horiuchi ◽  
Hideo Saji ◽  
Akira Yokoyama
Keyword(s):  
Ph Sensitive ◽  
Tumor Localization

A Mechanism for Reversibly Pausing a Self-Immolation Cascade in Response to pH Changes

2019 ◽  
Author(s):  
Derrick Roberts ◽  
Ben S. Pilgrim ◽  
Tristan Dell ◽  
Molly Stevens
Keyword(s):  
Local Environment ◽  
Chemical Signals ◽  
Ph Sensitive ◽  
First Report ◽  
Ph Changes ◽  
Self Immolation

We describe the first report of a self-immolation cascade that can be reversibly paused and reactivated in response to pH changes. This system employs a triazole-based self-immolative linker, which expresses a pH-sensitive intermediate during its elimination sequence. This allows the system to respond to pH cues within its local environment, thus establishing a new way to gate self-immolative release using fluctuating or transient chemical signals.<br>

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