Construction of Recombinant Fowlpox Virus (rFpv) Expressing HIV-1 Gag-pol Protein

2007 ◽  
Vol 23 (1) ◽  
pp. 64-68
Author(s):  
H TENG ◽  
S LU ◽  
D LIU ◽  
C JIANG ◽  
X ZHANG ◽  
...  
Keyword(s):  
Fowlpox Virus ◽  
Recombinant Fowlpox Virus ◽  
Hiv 1

scholarly journals An HIV-1 clade A/E DNA prime, recombinant fowlpox virus boost vaccine is safe, but non-immunogenic in a randomized phase I/IIa trial in Thai volunteers at low risk of HIV infection

2010 ◽  
Vol 6 (10) ◽  
pp. 835-840 ◽  
Author(s):  
Atchriya Hemachandra ◽  
Rebekah L Puls ◽  
Stephen Kerr ◽  
Sunee Sirivichayakul ◽  
Pattarawat Thantiworasit ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Phase I ◽  
Low Risk ◽  
Fowlpox Virus ◽  
Boost Vaccine ◽  
Recombinant Fowlpox Virus ◽  
Hiv 1

A randomized, placebo-controlled phase I trial of DNA prime, recombinant fowlpox virus boost prophylactic vaccine for HIV-1

AIDS ◽  
2006 ◽  
Vol 20 (2) ◽  
pp. 294-297 ◽  
Author(s):  
Anthony D Kelleher ◽  
Rebekah L Puls ◽  
Mark Bebbington ◽  
David Boyle ◽  
Rosemary Ffrench ◽  
...  
Keyword(s):  
Phase I ◽  
Phase I Trial ◽  
Prophylactic Vaccine ◽  
Fowlpox Virus ◽  
Recombinant Fowlpox Virus ◽  
Hiv 1

scholarly journals Enhanced T-Cell Immunogenicity and Protective Efficacy of a Human Immunodeficiency Virus Type 1 Vaccine Regimen Consisting of Consecutive Priming with DNA and Boosting with Recombinant Fowlpox Virus

1998 ◽  
Vol 72 (12) ◽  
pp. 10180-10188 ◽  
Author(s):  
Stephen J. Kent ◽  
Anne Zhao ◽  
Susan J. Best ◽  
Jenalle D. Chandler ◽  
David B. Boyle ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
T Cell Responses ◽  
Fowlpox Virus ◽  
Vaccine Regimen ◽  
Cell Responses ◽  
Immunodeficiency Virus ◽  
Recombinant Fowlpox Virus ◽  
Hiv 1

ABSTRACT The induction of human immunodeficiency virus (HIV)-specific T-cell responses is widely seen as critical to the development of effective immunity to HIV type 1 (HIV-1). Plasmid DNA and recombinant fowlpox virus (rFPV) vaccines are among the most promising safe HIV-1 vaccine candidates. However, the immunity induced by either vaccine alone may be insufficient to provide durable protection against HIV-1 infection. We evaluated a consecutive immunization strategy involving priming with DNA and boosting with rFPV vaccines encoding common HIV-1 antigens. In mice, this approach induced greater HIV-1-specific immunity than either vector alone and protected mice from challenge with a recombinant vaccinia virus expressing HIV-1 antigens. In macaques, a dramatic boosting effect on DNA vaccine-primed HIV-1-specific helper and cytotoxic T-lymphocyte responses, but a decline in HIV-1 antibody titers, was observed following rFPV immunization. The vaccine regimen protected macaques from an intravenous HIV-1 challenge, with the resistance most likely mediated by T-cell responses. These studies suggest a safe strategy for the enhanced generation of T-cell-mediated protective immunity to HIV-1.

Construction and characterization of a recombinant fowlpox virus containing HIV-1 multi-epitope-p24 chimeric gene in mice

2007 ◽  
Vol 50 (2) ◽  
pp. 212-220 ◽  
Author(s):  
LiShu Zhang ◽  
NingYi Jin ◽  
YingJin Song ◽  
Hong Wang ◽  
HeWen Ma ◽  
...  
Keyword(s):  
Chimeric Gene ◽  
Fowlpox Virus ◽  
Recombinant Fowlpox Virus ◽  
Hiv 1

scholarly journals Expression of bacteriophage T7 RNA polymerase in avian and mammalian cells by a recombinant fowlpox virus

1996 ◽  
Vol 77 (5) ◽  
pp. 963-967 ◽  
Author(s):  
P. Britton ◽  
P. Green ◽  
S. Kottier ◽  
K. L. Mawditt ◽  
Z. Penzes ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Mammalian Cells ◽  
T7 Rna Polymerase ◽  
Bacteriophage T7 ◽  
Fowlpox Virus ◽  
Recombinant Fowlpox Virus

A vaccination strategy consisting of Semliki-Forest-virus (SFV) DNA prime and fowlpox-virus boost significantly protects mice from a recombinant (HIV-1) vaccinia-virus infection

2005 ◽  
Vol 41 (1) ◽  
pp. 59 ◽  
Author(s):  
Dania M. Vázquez-Blomquist ◽  
Diógenes Quintana-Vázquez ◽  
Ernesto Galbán Rodríguez ◽  
Antonieta M. Herrera Buch ◽  
Carlos A. Duarte Cano
Keyword(s):  
Virus Infection ◽  
Vaccinia Virus ◽  
Semliki Forest Virus ◽  
Vaccination Strategy ◽  
Fowlpox Virus ◽  
Vaccinia Virus Infection ◽  
Hiv 1

scholarly journals SIV-Specific Antibodies are Elicited by a Recombinant Fowlpox Virus Co-expressing SIV Gag and envT

2018 ◽  
Vol 58 (3) ◽  
pp. 345-352
Author(s):  
Yilong Zhu ◽  
Shouwen Du ◽  
Yang Zhang ◽  
Jingwei Liu ◽  
Yan Guo ◽  
...  
Keyword(s):  
Fowlpox Virus ◽  
Specific Antibodies ◽  
Recombinant Fowlpox Virus
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