Vaginal Obliteration in a Woman With a History of Cutaneous T-Cell Lymphoma: The Results of Combined Chemotherapy-induced Gonadal Toxicity and Lymphoma Relapse

Primary cutaneous CD30-positive large cell lymphoma (CD30+ PCLCL) is a rare subtype of cutaneous T-cell lymphoma (CTCL) that can present in a variety of ways. We report a patient with a three-month history of an enlarging, exophytic mass with two smaller satellite lesions on the left forearm. Biopsy of the skin stained positive for CD30, and, after thorough systemic evaluation, a diagnosis of CD30+ PCLCL was made. When PCLCL is suspected, it is important to perform immunohistological studies for CD30 types and conduct a thorough workup to rule out systemic LCL. These measures will reduce the use of unnecessarily aggressive chemotherapy regimens for CD30+ PCLCL, an indolent disease with a favorable prognosis.

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Matrix Metalloproteinase-2 Promoter Genotype as a Marker of Cutaneous T-Cell Lymphoma Early Stage

Journal of Biomedicine and Biotechnology ◽

10.1155/2010/805907 ◽

2010 ◽

Vol 2010 ◽

pp. 1-5 ◽

Cited By ~ 6

Author(s):

Anna Vasku ◽

Julie Bienertova Vasku ◽

Miroslav Nečas ◽

Vladimir Vasku

Keyword(s):

T Cell ◽

Skin Diseases ◽

Cell Lymphoma ◽

Early Stage ◽

Clinical Diagnostics ◽

T Cell Lymphoma ◽

Matrix Metalloproteinase 2 ◽

Potential Candidate ◽

Cutaneous T Cell Lymphoma ◽

History Of

The aim of the study was to investigate the DNA polymorphic genotype in MMP-2 promoter gene as a potential candidate region for the development of the cutaneous T-cell lymphoma (CTCL) and/or its progression. A total of 89 Czech patients with CTCL (including 23 patients with large plaque parapsoriasis) were compared to 198 controls of similar age and sex distribution, without personal or family history of chronic skin diseases and without personal history of malignancy. The three selected polymorphisms in the promoter of MMP-2 gene (−1575G/A,−1306C/T, and−790T/G) were determined using the PCR-based methodology with RFLP. In our cohort, the associatedGGCCTTMMP-2 promoter genotype was highly significantly more frequent in CTCL-Ia stage patients compared to patients with parapsoriasis, the tests having high sensitivity and specificity (78%, 83%, resp.). To conclude, use of associated MMP-2 promoter genotype as a DNA marker might make it possible to distinguish between the patients with parapsoriasis and those with CTCL stage Ia, which could substantially improve possibilities of clinical diagnostics, therapy design, and prognosis of this serious condition in the early stages.

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Granulomatous Slack Skin with Hypercalcemia Indolently Mimicking Sarcoidosis

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20214921 ◽

2021 ◽

Vol 8 (1) ◽

pp. 116

Author(s):

Sarah Colando ◽

Jennifer Seyffert ◽

Daniel Rivlin

Keyword(s):

T Cell ◽

Rare Variant ◽

Cell Lymphoma ◽

T Cell Lymphoma ◽

Elastic Fibers ◽

Cutaneous T Cell Lymphoma ◽

Unique Case ◽

History Of ◽

Previously Treated

<p class="abstract">Granulomatous slack skin is a rare variant of cutaneous T-cell lymphoma characterized by lax skin and granulomatous infiltrate with loss of elastic fibers on histology. We report a unique case of a female presenting with CD30-granulomatous slack skin complicated by hypercalcemia, initially diagnosed, and managed as sarcoidosis. Interestingly, she had a history of previously treated CD30+ cutaneous T-cell lymphoma. Granulomatous slack skin can frequently mimic other benign and malignant cutaneous diseases, prompting the need for clinical vigilance from dermatologists.</p>

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