31 The role of comprehensive geriatric assessment (CGA) in the management of stage 3 hepatocellular carcinoma in the elderly

2006 ◽  
Vol 60 ◽  
pp. S35-S36 ◽  
Author(s):  
C.H. Soejono
2012 ◽  
Vol 08 (02) ◽  
pp. 85 ◽  
Author(s):  
Maria José Molina-Garrido ◽  
Carmen Guillén-Ponce ◽  
◽  

The field of oncogeriatrics considers the comprehensive geriatric assessment (CGA) as the main tool for distinguishing between patients who are frail and those who are not frail. The aim of our study was to determine the role of the CGA in predicting the risk of frailty in elderly patients. This prospective study was conducted at the Cancer in the Elderly Unit of the Medical Oncology Department at the Virgen de la Luz General Hospital in Cuenca, Spain. Demographic data and information about the CGA were collected. Using a bivariate logistic regression analysis, these factors were analysed and the factors that are associated with the risk of frailty were determined, as measured by the Barber questionnaire (BQ). We included 262 patients in the study with a mean age of 79 years (range 70–93 years). Seventy-four percent of the patients (n=194) had a risk of frailty as measured by the BQ. In the bivariate analysis, only age (odds ratio [OR] 1.064, 95 % confidence interval [CI] 1.000–1.133, p=0.051), being divorced, widowed or single (OR 0.450, 95 % CI 0.216–0.937, p=0.033) and being dependent in instrumental activities of daily living (IADL) (OR 3.003, 95 % CI 1.181–7.638, p=0.021) were associated with a higher risk of frailty. The risk of being frail in an elderly patient with cancer is higher in patients dependent in IADL and in patients who are not married. Age is another risk factor for frailty.


2012 ◽  
Author(s):  
Mariarosa Mazzolini ◽  
Lucia Bazzo ◽  
Roberta Cascarilla ◽  
Annalisa Anni ◽  
Romina Spina ◽  
...  

2020 ◽  
Vol 11 (2) ◽  
pp. 194-196
Author(s):  
Ashwin Shinde ◽  
Jessica Vazquez ◽  
Jennifer Novak ◽  
Mina S. Sedrak ◽  
Arya Amini

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Alberto Castagna ◽  
Davide Bolignano ◽  
Irma Figlia ◽  
Rosa Paola Cerra ◽  
Carmen Ruberto ◽  
...  

Abstract Background and Aims Renal function impairment is highly pervasive in the elderly and triggers increased morbidity and mortality. Comprehensive geriatric assessment (CGA) is a validated multidisciplinary instrument to assess medical, psychosocial and functional limitations of old patients with diagnostic and risk-stratification purposes. In a focused cohort of frail individuals, we aimed at evaluating possible relationships between single CGA items and renal function. Method 254 consecutive elderly subjects (mean age 79.9±6.6 years, female 65.8%) from the geriatric division of a large Italian community hospital were studied. We collected clinical data including CGA and renal function (CKD-EPI formula). CGA single items included the Cumulative Illness Rating Scale (CIRS), the Exton Smith Scale (ESS), the Mini Nutritional Assessment Short Form (MNA-SF), the Katz‘s Activities of Daily Living (ADL), the Lawton’s Instrumental Activities of Daily Living (IADL), the Short Portable Mental Status Questionnaire (SPMSQ) and the amount of drugs administered (AD). Results Mean eGFR was 66.37±30.94 mL/min/1.73 m2. Overall, the reported CIRS, ESS, MNA, ADL and AD scores were low (7.6±3.3) while IADL and SPMQ were on a mild range, denoting a potential alarm signal for poor prognosis and the risk for adverse outcomes. At univariate analyses, eGFR was significantly associated with CIRS (R=-0.389, p<0.0001), ESS (R=0.355, p<0.0001), MNA (R=0.394, p<0.0001), ADL (R=0.394, p<0.0001), AD (R=-0.374, p<0.0001. while a weak, although significant correlation was found with IADL (R=0.131, p=0.038) and SPMSQ (R=-0.141, p=0.038). In a fully adjusted multivariate analyses only SPMSQ (ß=-0.174, p=0.04), ADL (ß=0.182, p=0.012), IADL (ß =0.209, p=0.003) and AD (ß=-0.354, p<0.0001) remained significant predictors of residual renal function. Conclusion In elderly frail subjects, residual renal function may influence daily life and cognitive activities, the perceived quality of living and the entity of drug assumption. Inclusion of renal function within a comprehensive geriatric assessment could help improving risk stratification in the elderly


2013 ◽  
Vol 09 (02) ◽  
pp. 138
Author(s):  
MJ Molina-Garrido ◽  
Carmen Guillén-Ponce ◽  
Nieves Bravo Delgado ◽  
Antonia Mora-Rufete ◽  
◽  
...  

The incidence of cancer increases dramatically with age and is reported to be 12 to 36 times higher in patients 65 years or older compared with those aged 25 to 44 years. The challenge for oncologists is to determine the optimum treatment for elderly patients. The Comprehensive Geriatric Assessment (CGA) is the main tool to take decisions in elderly patients diagnosed with cancer. And many screening tools have been tested to select which patients should be taken or not a complete CGA. Matters that influence geriatric assessment in the oncologic population will be highlighted in this article.


2014 ◽  
Vol 32 (3_suppl) ◽  
pp. 202-202
Author(s):  
Takintope Akinbiyi ◽  
Atuhani S. Burnett ◽  
Philip Ernst ◽  
Marisa Cevasco ◽  
Donald A. McCain ◽  
...  

202 Background: Hepatocellular carcinoma (HCC) is a significant source of morbidity and mortality amongst the elderly population. In appropriately selected patients, surgery is known to confer a survival advantage. Octagenarians, however, given their remaining life expectancy may receive limited benefit from surgery. Nevertheless, insufficient information is available in the literature on the survival benefit of surgery in octagenarians with HCC. Methods: Octogenarians with HCC were selected from the Surveillance, Epidemiology, and End Results (SEER) database between 1998 and 2009. We evaluated patients who underwent surgical resection and those that declined to assess the impact surgery has on overall survival in this population. Results: A total of 8,614 with HCC were identified in the SEER database, of which surgery was recommended for 3,529 (41%). A total of 1,002 patients (28%) underwent surgery and 2,497 (71%) declined. Although there was a trend towards improved survival in the surgery group (7.91 months) vs the non-surgical group (7.03 months), there was no statistically significant difference in survival between the two groups (p = 0.09). Conclusions: Our study demonstrates that octagenarians as a whole do not experience a survival benefit from surgical resection for HCC. Subgroup analysis, however, may ultimately identify benefit in specific disease stages or patients with fewer comorbidities.


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