Dose-dependent enhancement of motor activation and motor skills by a single dose of paroxetine, a serotonin reuptake inhibitor. A double-blind, placebo-controlled fMRI study in healthy subjects

NeuroImage ◽  
2001 ◽  
Vol 13 (6) ◽  
pp. 1218
Author(s):  
Isabelle Loubinoux ◽  
Jeremie Pariente ◽  
Christophe Carel ◽  
Claude Manelfe ◽  
Olivier Rascol ◽  
...  
Keyword(s):  
Single Dose ◽  
Motor Skills ◽  
Reuptake Inhibitor ◽  
Serotonin Reuptake ◽  
Healthy Subjects ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Motor Activation ◽  
Fmri Study ◽  
Dose Dependent

A Single Dose of the Serotonin Neurotransmission Agonist Paroxetine Enhances Motor Output: Double-Blind, Placebo-Controlled, fMRI Study in Healthy Subjects

NeuroImage ◽  
2002 ◽  
Vol 15 (1) ◽  
pp. 26-36 ◽  
Author(s):  
Isabelle Loubinoux ◽  
Jérémie Pariente ◽  
Kader Boulanouar ◽  
Christophe Carel ◽  
Claude Manelfe ◽  
...  
Keyword(s):  
Single Dose ◽  
Healthy Subjects ◽  
Motor Output ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Fmri Study

The Predictive Value of the Dexamethasone Suppression Test

1989 ◽  
Vol 155 (05) ◽  
pp. 667-672 ◽  
Author(s):  
Eric D. Peselow ◽  
Michael Stanley ◽  
Ann-Marie Filippi ◽  
Faouzia Barouche ◽  
Paul Goodnick ◽  
...  
Keyword(s):  
Selective Serotonin Reuptake Inhibitor ◽  
Reuptake Inhibitor ◽  
Predictive Value ◽  
Serotonin Reuptake ◽  
Dexamethasone Suppression Test ◽  
Selective Serotonin ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Suppression Test ◽  
Dexamethasone Suppression

We evaluated the dexamethasone suppression test (DST) as a predictor of response to drugs and placebo in 105 patients, in a large double-blind placebo-controlled out-patient trial to determine the efficacy of paroxetine HCI, a selective serotonin reuptake inhibitor, compared with that of imipramine HCI and placebo. The presence of a positive or negative DST did not predict response to either paroxetine or imipramine. However, a positive DST predicted a poorer response to placebo: only 3 out of 18 patients who showed DST non-suppression responded to placebo, as opposed to 11 out of 21 who exhibited DST suppression (P<0.05). A positive DST was associated with a 61% response to drugs and a 16% response to placebo. This finding suggests that the presence of a positive DST implies the need for active somatic treatment.

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