Periovulatory and interleukin (IL)-1–dependent regulation of IL-6 in the immature rat ovary: A specific IL-1 receptor-mediated eicosanoid-dependent effect

2000 ◽  
Vol 7 (5) ◽  
pp. 301-308 ◽  
Author(s):  
K Chung
1963 ◽  
Vol 42 (4) ◽  
pp. 480-484 ◽  
Author(s):  
B. Eckstein ◽  
R. Landsberg

ABSTRACT The succinic, malic and isocitric dehydrogenases in the ovary of immature and mature, normal and serum gonadotrophin injected rats were examined. The Qo2 of these enzymes were markedly enhanced in the gonadotrophin injected rats of both age groups, except in the case of succinic dehydrogenase in the ovary of the immature rats, where a slight non-significant decrease was noted. It is concluded that in the mature rat ovary, gonadotrophin administration stimulates the activity of all the examined dehydrogenases of the citric acid cycle, whereas in the immature rat ovary, at least the isocitric- and malic dehydrogenases are thus stimulated.


1979 ◽  
Vol 35 (2) ◽  
pp. 271-273 ◽  
Author(s):  
J. W. Siebers ◽  
Th. Bauknecht ◽  
U. Müller ◽  
W. Engel
Keyword(s):  

1978 ◽  
Vol 88 (2) ◽  
pp. 375-382 ◽  
Author(s):  
A. J. Hage ◽  
A. C. Groen-Klevant ◽  
R. Welschen

ABSTRACT In ovaries of immature rats the following parameters were estimated from autoradiographs prepared after pulse labelling with tritiated thymidine: 1) The time it takes follicles to grow from one stage of development to another. This could be derived from the total number of granulosa cells in these stages and from their doubling times. The doubling time of granulosa cells was determined from their labelling index and the duration of their DNA-synthesis phase. 2) The number of follicles present in the ovary at different ages. 3) The number of follicles, which start on their development at different ages. It was found, that more follicles start to grow in 8 and 16 days old rats (2.0/h) than in 28 days old ones (1.0/h). Moreover, the follicles grow somewhat faster earlier in life than later. The development from a follicle with one layer of granulosa cells to one with several layers and antrum formation takes about 15 days in the first half of the period of immaturity while it takes about 17 days as the animal approaches maturity.


2009 ◽  
Vol 126 ◽  
pp. S226
Author(s):  
Fahimeh Mirakhori ◽  
Bahman Zeynali ◽  
Azita Parvaneh Tafreshi ◽  
Ghamar Taj Hossein ◽  
Amaneh Shirmohammadian

Endocrinology ◽  
1960 ◽  
Vol 66 (1) ◽  
pp. 121-128 ◽  
Author(s):  
J. E. MEYER ◽  
J. T. BRADBURY
Keyword(s):  

Reproduction ◽  
1990 ◽  
Vol 90 (2) ◽  
pp. 465-472 ◽  
Author(s):  
G. Schmidt ◽  
J. Jorgensen ◽  
P. Kannisto ◽  
F. Liedberg ◽  
B. Ottesen ◽  
...  

Steroids ◽  
1981 ◽  
Vol 37 (6) ◽  
pp. 627-634 ◽  
Author(s):  
Ckon-Hwa Tsai ◽  
Donald C. Johnson

1976 ◽  
Vol 82 (2) ◽  
pp. 413-425 ◽  
Author(s):  
T. Sashida ◽  
D. C. Johnson

ABSTRACT Radioimmunoassays were used to measure changes in progesterone, testosterone, androstenedione, oestradiol, gonadotrophin and ovarian cyclic AMP in immature female rats during the first 24 h after exposure to slowly (PMS) or rapidly (FSH + LH) disappearing gonadotrophins. Cyclic AMP was increased 30 min after injection of either kind of gonadotrophin but it had returned to control level within 4 h. Serum and ovarian testosterone and androstenedione also increased to a peak at 30 min but decreased to base line by the 4th h. Multiple injections of FSH + LH maintained an elevated serum testosterone level but they had little effect upon the secretion of androstenedione. Serum and ovarian progesterone increased quickly after treatment with gonadotrophin. With PMS the peak in the serum was reached at 8 h, it remained high for 4 h and then fell precipitously between the 12th and 16th h. FSH + LH produced a prompt increase in serum progesterone but the level could be maintained only by repeated doses given every 4 h. Oestradiol was not increased in the serum or the ovary until 20 h after PMS. One or two doses of FSH + LH did not produce an increase in oestrogen but a transient increase was found with 3 doses; 4 doses kept an elevated level of oestradiol for 12 h. These results indicate that the aromatizing system of the immature rat ovary is relatively inactive and that continual stimulation by gonadotrophin for about 10–12 h is necessary to bring about increased function. In contrast, the mechanisms for the synthesis and secretion of progesterone and androgens are very active and can be immediately stimulated by exposure to gonadotrophins.


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