Quantitation of T2 lesion load in multiple sclerosis with magnetic resonance imaging: A pilot study of a probabilistic neural network approach

1997 ◽  
Vol 4 (6) ◽  
pp. 431-437 ◽  
Author(s):  
Ulrich Raff ◽  
Patricio F. Vargas ◽  
Gonzalo M. Rojas ◽  
Ann L. Scherzinger ◽  
Jack H. Simon
2013 ◽  
Vol 20 (1) ◽  
pp. 72-80 ◽  
Author(s):  
H Kearney ◽  
MA Rocca ◽  
P Valsasina ◽  
L Balk ◽  
J Sastre-Garriga ◽  
...  

Background: Understanding long-term disability in multiple sclerosis (MS) is a key goal of research; it is relevant to how we monitor and treat the disease. Objectives: The Magnetic Imaging in MS (MAGNIMS) collaborative group sought to determine the relationship of brain lesion load, and brain and spinal cord atrophy, with physical disability in patients with long-established MS. Methods: Patients had a magnetic resonance imaging (MRI) scan of their brain and spinal cord, from which we determined brain grey (GMF) and white matter (WMF) fractional volumes, upper cervical spinal cord cross-sectional area (UCCA) and brain T2-lesion volume (T2LV). We assessed patient disability using the Expanded Disability Status Scale (EDSS). We analysed associations between EDSS and MRI measures, using two regression models (dividing cohort by EDSS into two and four sub-groups). Results: In the binary model, UCCA ( p < 0.01) and T2LV ( p = 0.02) were independently associated with the requirement of a walking aid. In the four-category model UCCA ( p < 0.01), T2LV ( p = 0.02) and GMF ( p = 0.04) were independently associated with disability. Conclusions: Long-term physical disability was independently linked with atrophy of the spinal cord and brain T2 lesion load, and less consistently, with brain grey matter atrophy. Combinations of spinal cord and brain MRI measures may be required to capture clinically-relevant information in people with MS of long disease duration.


Author(s):  
Seba Aziz Sahym

Given the circumstances of the countries in which wars, political instability, and other uncertainties are passing that make the atmosphere impure, which have caused many diseases, one of these diseases that has spread widely is cancer. Cancer is a very common disease, and many of them affect a person and lead him or her to death. Among these diseases, which have been common in recent years specifically the brain tumors that they need early diagnosis and do not cause the death of the person. Furthermore, many studies in the field of brain cancer detection have been done, but the best solution is still missing. Therefore, in this paper, a reliable method is proposed to detect brain tumors, extract its properties, and classify the tumor using Magnetic Resonance Imaging (MRI) through the artificial neural network.  In the proposed system, an essential part of image processing is the analysis and processing of digital images, especially to improve their quality, Bilateral Filter is used to improving image clarity and any image noise in this method preserves edges. After that, the distinctive properties of the image are extracted using the Histogram of Oriented Gradient (HOG) method. Thus, the extracted features are strong and can be classified as a Probabilistic Neural Network (PNN), this is what distinguishes our work from the previous works. The advantage obtained is granted to the PNN Classifier, which is used to train and test the accuracy of performance in perceiving the location of the tumour in MRI images of the brain accuracy as it resolves 99.5%.


2013 ◽  
Vol 20 (3) ◽  
pp. 349-355 ◽  
Author(s):  
Jie Luo ◽  
Dmitriy A Yablonskiy ◽  
Charles F Hildebolt ◽  
Samantha Lancia ◽  
Anne H Cross

Background: Conventional magnetic resonance imaging (MRI) methods do not quantify the severity of multiple sclerosis (MS) white matter lesions or measure pathology within normal-appearing white matter (NAWM). Objective: Gradient Echo Plural Contrast Imaging (GEPCI), a fast MRI technique producing inherently co-registered images for qualitative and quantitative assessment of MS, was used to 1) correlate with disability; 2) distinguish clinical MS subtypes; 3) determine prevalence of veins co-localized within lesions in WM. Methods: Thirty subjects representing relapsing–remitting MS (RRMS), secondary progressive MS (SPMS) and primary progressive MS (PPMS) subtypes were scanned with clinical and GEPCI protocols. Standard measures of physical disability and cognition were correlated with magnetic resonance metrics. Lesions with central veins were counted for RRMS subjects. Results: Tissue damage load (TDL-GEPCI) and lesion load (LL-GEPCI) derived with GEPCI correlated better with MS functional composite (MSFC) measures and most other neurologic measures than lesion load derived with FLAIR (LL-FLAIR). GEPCI correctly classified clinical subtypes in 70% subjects. A central vein could be identified in 76% of WM lesions in RRMS subjects on GEPCI T2*-SWI images. Conclusion: GEPCI lesion metrics correlated better with neurologic disability than lesion load derived using FLAIR imaging, and showed promise in classifying clinical subtypes of MS. These improvements are likely attributable to the ability of GEPCI to quantify tissue damage.


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