OP38 – 3035: Incidence of and risk factors for neurological complications of cardiac bypass surgery in children with congenital heart disease

Background: Adults with congenital heart disease are a growing population. We describe surgical interventions, short- and long-term mortality and morbidity, and risk factors for adverse events in a population-based cohort. Methods: Patients over or equal to 18 years with congenital heart disease who underwent cardiac surgery at Aarhus University Hospital, Denmark, from 1994 to 2012 were included in the study. Diagnoses, surgical procedures, postoperative complications, and survival were identified in hospital databases, medical records, and the Danish Civil Registration System. Results: Four hundred seventy-four surgeries were performed in 445 adults (50% men). The median age was 39 years (range 18-83). Thirty-nine percent had previous surgical or catheter-based interventions. Thirty-day and in-hospital mortality were 1.1%. Postoperative complications occurred in 50% of cases, most were minor such as temporary arrhythmias and pneumonia. Major complications included postoperative bleeding necessitating intervention (6%), stroke (2%), and acute temporary renal failure (1%). Multivariate analysis identified RACHS-1 categories over or equal to 3 compared to category 1 (odds ratio (OR) = 2.3; 95% confidence interval (CI): 1.5-3.7), New York Heart Association functional class III and IV compared to class I (OR = 2.2; 95% CI: 1.3-3.7) and age at surgery (OR = 1.03, 95% CI: 1.01-1.04), as risk factors for adverse events. Survival during a median follow-up of 7.8 years (range 0 days-21.4 years) was 85% (95% CI: 80%-89%). Conclusion: Adults with congenital heart disease constitute a growing population with the need for cardiac surgery. Postoperative complications are frequent but early and late mortality are low.

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Socio-hygienic and biomedical risk factors for congenital heart disease in children

Yakut Medical Journal ◽

10.25789/ymj.2018.62.37 ◽

2018 ◽

pp. 116-119

Author(s):

T.I. Nelunova ◽

T.E. Burtseva ◽

V.G. Chasnyk ◽

S.A. Evseeva

Keyword(s):

Risk Factors ◽

Congenital Heart Disease ◽

Heart Disease ◽

Congenital Heart

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Chylothorax after surgery on congenital heart disease in newborns and infants -risk factors and efficacy of MCT-diet

Journal of Cardiothoracic Surgery ◽

10.1186/1749-8090-5-127 ◽

2010 ◽

Vol 5 (1) ◽

Cited By ~ 43

Author(s):

Eva S Biewer ◽

Christoph Zürn ◽

Raoul Arnold ◽

Martin Glöckler ◽

Jürgen Schulte-Mönting ◽

...

Keyword(s):

Risk Factors ◽

Congenital Heart Disease ◽

Heart Disease ◽

Congenital Heart

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Risk factors for nosocomial infections after cardiac surgery in newborns with congenital heart disease

Pediatrics & Neonatology ◽

10.1016/j.pedneo.2018.07.009 ◽

2018 ◽

Vol 59 (4) ◽

pp. 327-328 ◽

Cited By ~ 1

Author(s):

Pei-Lan Shao

Keyword(s):

Risk Factors ◽

Congenital Heart Disease ◽

Cardiac Surgery ◽

Heart Disease ◽

Nosocomial Infections ◽

Congenital Heart

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Environmental Risk Factors and Congenital Heart Disease: An Umbrella Review of 165 Systematic Reviews and Meta-Analyses With More Than 120 Million Participants

Frontiers in Cardiovascular Medicine ◽

10.3389/fcvm.2021.640729 ◽

2021 ◽

Vol 8 ◽

Author(s):

Tie-Ning Zhang ◽

Qi-Jun Wu ◽

Ya-Shu Liu ◽

Jia-Le Lv ◽

Hui Sun ◽

...

Keyword(s):

Risk Factors ◽

Congenital Heart Disease ◽

Heart Disease ◽

Environmental Factors ◽

Congenital Heart ◽

Prediction Intervals ◽

Umbrella Review ◽

Wide Range ◽

Null Value ◽

Meta Analyses

Background: The etiology of congenital heart disease (CHD) has been extensively studied in the past decades. Therefore, it is critical to clarify clear hierarchies of evidence between types of environmental factors and CHD.Methods: Electronic searches in PubMed, Embase, Web of Science, Cochrane database were conducted from inception to April 20, 2020 for meta-analyses investigating the aforementioned topic.Results: Overall, 41 studies including a total of 165 meta-analyses of different environmental factors and CHD were examined, covering a wide range of risk factors. The summary random effects estimates were significant at P < 0.05 in 63 meta-analyses (38%), and 15 associations (9%) were significant at P < 10−6. Of these meta-analyses, eventually one risk factor (severe obesity; relative risk: 1.38, 95% confidence interval: 1.30–1.47) had significant summary associations at P < 10−6, included more than 1,000 cases, had 95% prediction intervals excluding the null value, and were not suggestive of large heterogeneity (I2 < 50%), small-study effects (P-value for Egger's test > 0.10), or excess significance (P > 0.10). Eight associations (5%) (including maternal lithium exposure, maternal obesity, maternal alcohol consumption, and maternal fever) had results that were significant at P < 10−6, included more than 1,000 cases, and had 95% prediction intervals excluding the null value (highly suggestive).Conclusion: This umbrella review shows that many environmental factors have substantial evidence in relation to the risk of developing CHD. More and better-designed studies are needed to establish robust evidence between environmental factors and CHD.Systematic Review Registration: [PROSPERO], identifier [CRD42020193381].

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Risk Factors Associated with Congenital Heart Disease in Patients Presenting to Aljalila Cardiology Clinic between January 2020- May 2020: A Case Control Study

Journal of Cardiology Research Review & Reports ◽

10.47363/jcrrr/2021(3)143 ◽

2021 ◽

pp. 1-6

Author(s):

Samah Alasrawi ◽

◽

Hessa Almansoori ◽

Keyword(s):

Risk Factors ◽

Congenital Heart Disease ◽

Heart Disease ◽

Maternal Smoking ◽

Congenital Heart ◽

Case Control Study ◽

Maternal Diabetes ◽

Case Control ◽

Cardiology Clinic ◽

Control Study

Objective: To investigate the association of maternal diabetes, maternal smoking and syndromes with congenital heart disease (CHD) in patients attending Aljalila cardiology clinic between January 2020 and May of 2020. Methods: A case control study to assess the association of maternal diabetes, maternal smoking and syndromes with CHD. All patients that presented to the clinic between January 2020 and May of 2020 were included. An interviewer administered questionnaire was used to record the presence of maternal diabetes, maternal smoking, and the type of syndrome and type of CHD. Patients with CHD were included in the case group and patients who did not have CHD were in the control group. Age, gender, and nationality were also collected from the hospital records. Fisher exact test and logistic regression was used to analyze the results. Results: A total of 177 cases and 211 controls were recruited. All the risk factors increase the risk of CHD, with maternal diabetes (OR 6.3, 95% CI 2.7-14.6) having the strongest association, then syndromes (OR 5.1, 95% CI 2.3-11.3) and lastly maternal smoking (OR 4.0, 95% CI 1.0-16.3). The most common type of CHD is ventricular septal defect. Conclusion: Maternal diabetes, maternal smoking and syndromes are significant risk factors of CHD in children visiting Aljalila cardiology clinic. Action needs to be taken in order to decrease these risk factors and so, decrease the incidence of CHD in the future. Clearly, more research is needed in order to identify other risk factors for patients in the United Arab Emirates (UAE)

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