GP4-7: ProIGF-II not matureIGF-II promotes estrogen independent breast cancer growth and metastasis in a SCID and Nude mouse model: differential signallng mechanisms thru IGF and Insulin receptors and phosphorylation/activation of estrogen and progesterone receptors

2014 ◽  
Vol 24 ◽  
pp. S29-S30
Author(s):  
T. Jian ◽  
S. Kalla-Singh ◽  
V.K. Radhakrishnan ◽  
M.A. De León ◽  
D. DeLeon
2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Manasi Das ◽  
Emilie Gross ◽  
Deepak Kumar ◽  
Consuelo Sauceda ◽  
Hyun‐Tae Park ◽  
...  

2021 ◽  
Author(s):  
Sebastian Giulianelli ◽  
Caroline A. Lamb ◽  
Claudia Lanari

Abstract Progesterone receptors (PR) play a pivotal role in many female reproductive tissues such as the uterus, the ovary, and the mammary gland (MG). Moreover, PR play a key role in breast cancer growth and progression. This has led to the development and study of different progestins and antiprogestins, many of which are currently being tested in clinical trials for cancer treatment. Recent reviews have addressed the role of PR in MG development, carcinogenesis, and breast cancer growth. Thus, in this review, in addition to making an overview on PR action in normal and tumor breast, the focus has been put on highlighting the still unresolved topics on hormone treatment involving PR isoforms and breast cancer prognosis.


2000 ◽  
Vol 21 (5) ◽  
pp. 499-500
Author(s):  
A. M. Scott ◽  
K. Tahtis ◽  
F. E. Smyth ◽  
F. -T. Lee ◽  
M. Brechbiel ◽  
...  

Diabetologia ◽  
2017 ◽  
Vol 60 (4) ◽  
pp. 758-759
Author(s):  
Emily J. Gallagher ◽  
Zara Zelenko ◽  
Aviva Tobin-Hess ◽  
Ulrich Werner ◽  
Norbert Tennagels ◽  
...  

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