PND35 MEASURING THE IMPACT OF RESTLESS LEGS SYNDROME (RLS) ON QUALITY OF LIFE: A SYSTEMATIC REVIEW

Restless legs syndrome (RLS), also known as Willis–Ekbom Disorder (WED), is a condition associated with nocturnal sensorimotor symptoms that can result in significant sleep disruption. RLS is a prevalent condition, affecting an estimated 3.9–14.3 % of the US population. Despite the most recently reported prevalence studies, many experts in the field still believe RLS is a generally underdiagnosed condition. RLS can negatively affect a patient’s quality of life (QoL) across several domains, such as daytime sleepiness, decreased general health, decreased immune function, stress and mood. Of those patients with moderate-to-severe symptoms that require treatment, the currently available therapeutic options (e.g. iron supplements, dopamine agonists, benzodiazepines, opioids and anticonvulsants) can also come with adverse side effects that can further impact QoL. The purpose of this article is to examine the QoL deficits experienced by RLS patients.

Download Full-text

Current trends in the management of uremic restless legs syndrome: A systematic review on aspects related to quality of life, cardiovascular mortality and survival

Sleep Medicine Reviews ◽

10.1016/j.smrv.2014.07.006 ◽

2015 ◽

Vol 21 ◽

pp. 39-49 ◽

Cited By ~ 21

Author(s):

Giorgos K. Sakkas ◽

Christoforos D. Giannaki ◽

Christina Karatzaferi ◽

Maria Maridaki ◽

Yiannis Koutedakis ◽

...

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Restless Legs Syndrome ◽

Cardiovascular Mortality ◽

Restless Legs ◽

Current Trends

Download Full-text

PO25-TH-13 Restless legs syndrome, the impact on quality of life

Journal of the Neurological Sciences ◽

10.1016/s0022-510x(09)71136-0 ◽

2009 ◽

Vol 285 ◽

pp. S298

Author(s):

A.P.D. Doneva ◽

K.P.K. Pili Kuzeva ◽

V.P.D. Donev

Keyword(s):

Quality Of Life ◽

Restless Legs Syndrome ◽

Restless Legs ◽

The Impact

Download Full-text

High prevalence of restless legs syndrome in cancer patients undergoing chemotherapy: Relationship with anxiety, depression and quality of life perception

Journal of Clinical Oncology ◽

10.1200/jco.2007.25.18_suppl.9032 ◽

2007 ◽

Vol 25 (18_suppl) ◽

pp. 9032-9032 ◽

Cited By ~ 1

Author(s):

A. Saini ◽

L. Ostacoli ◽

E. Sguazzotti ◽

S. Capogna ◽

C. Castronovo ◽

...

Keyword(s):

Quality Of Life ◽

Cancer Patients ◽

Restless Legs Syndrome ◽

Dopamine Agonists ◽

Well Being ◽

Dopamine Antagonist ◽

Restless Legs ◽

Anxiety Depression ◽

The Impact

9032 Background: The Restless Legs Syndrome (RLS) is one of the commonest neurological sensorimotor disorders consisting in periodic limbs movements during the sleeping time that lead to severe insomnia and quality of life deterioration. The prevalence of RLS in normal population is 7 and 11% in males and females respectively. RLS correlated with female sex and iron deficiency. Chronic pain, sensory polineuropathy and the use of dopamine antagonist drugs can induce or exacerbate RLS. Dopamine agonists are extremely active drugs in controlling RLS. The prevalence of RLS in cancer patients is unknown. Methods: The presence of RLS, by means of the essential diagnostic criteria provided by the International RLS Study Group (Allen RP, Sleep Med; 2003), was tested in 257 consecutive cancer patients (119 males and 138 females) with different malignancies belonging to two different Medical Oncology centres. All patients were receiving chemotherapy. Functional Assessment of Cancer Therapy General (FACT-G), Hospital Anxiety and Depression Scale (HADS) and Mini Mental Adjustment to Cancer Scale (Mini-MAC) questionnaires were administered concomitantly to assess the impact of RLS on quality of life, anxiety or depression and styles of coping, respectively. Results: RLS was present in 47 patients (18.3%), 14 males (11.8%) and 33 females (23.9%); (p=0.01). RLS directly correlated with pain (p<0.0001), nausea (p<0.001), worse physical well-being (p=0.007), emotional well- being (p=0.001) and functional well-being (p=0.02). RLS affected patients showed higher levels of anxiety (p<0.001) and depression (p=0.001). The styles of coping consisting in anxious preoccupation and hopeless were also more represented in the RLS affected patients (p=0.04 and p=0.02 respectively) than their counterparts. Conclusions: RLS is frequent and underdiagnosed in cancer patients. It may cause anxiety, depression and quality of life deterioration. Early RLS detection and prompt introduction of dopamine agonists may improve patient quality of life. No significant financial relationships to disclose.

Download Full-text

The Impact of Restless Legs Syndrome/Willis-Ekbom Disorder on Quality of Life

US Neurology ◽

10.17925/usn.2014.10.01.15 ◽

2014 ◽

Vol 10 (01) ◽

pp. 15

Author(s):

Aadi Kalloo ◽

Charlene E Gamaldo ◽

Anthony B Kwan ◽

Rachel E Salas ◽

◽

...

Keyword(s):

Quality Of Life ◽

Restless Legs Syndrome ◽

Sleep Disruption ◽

Iron Supplements ◽

Prevalence Studies ◽

Adverse Side Effects ◽

Restless Legs ◽

The Us ◽

The Impact

Restless legs syndrome (RLS), also known as WillisEkbom Disorder (WED), is a condition associated with nocturnal sensorimotor symptoms that can result in significant sleep disruption. RLS is a prevalent condition, affecting an estimated 3.914.3 % of the US population. Despite the most recently reported prevalence studies, many experts in the field still believe RLS is a generally underdiagnosed condition. RLS can negatively affect a patients quality of life (QoL) across several domains, such as daytime sleepiness, decreased general health, decreased immune function, stress, and mood. Of those patients with moderate-to-severe symptoms that require treatment, the currently available therapeutic options (e.g. iron supplements, dopamine agonists, benzodiazepines, opioids, and anticonvulsants) can also come with adverse side effects that can further impact QoL. The purpose of this article is to examine the QoL deficits experienced by RLS patients.

Download Full-text

Exercise efficacy and prescription during treatment for pancreatic ductal adenocarcinoma: a systematic review

BMC Cancer ◽

10.1186/s12885-020-07733-0 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Dominic O’Connor ◽

Malcolm Brown ◽

Martin Eatock ◽

Richard C. Turkington ◽

Gillian Prue

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Pancreatic Cancer ◽

Adjuvant Therapy ◽

Physical Function ◽

Meta Analysis ◽

Ductal Adenocarcinoma ◽

Key Stakeholders ◽

The Impact

Abstract Background Surgical resection remains the only curative treatment for pancreatic cancer and is associated with significant post-operative morbidity and mortality. Patients eligible for surgery, increasingly receive neo-adjuvant therapy before surgery or adjuvant therapy afterward, inherently exposing them to toxicity. As such, optimizing physical function through exercise during treatment remains imperative to optimize quality of life either before surgery or during rehabilitation. However, current exercise efficacy and prescription in pancreatic cancer is unknown. Therefore, this study aims to summarise the published literature on exercise studies conducted in patients with pancreatic cancer undergoing treatment with a focus on determining the current prescription and progression patterns being used in this population. Methods A systematic review of four databases identified studies evaluating the effects of exercise on aerobic fitness, muscle strength, physical function, body composition, fatigue and quality of life in participants with pancreatic cancer undergoing treatment, published up to 24 July 2020. Two reviewers independently reviewed and appraised the methodological quality of each study. Results Twelve studies with a total of 300 participants were included. Heterogeneity of the literature prevented meta-analysis. Exercise was associated with improvements in outcomes; however, study quality was variable with the majority of studies receiving a weak rating. Conclusions High quality evidence regarding the efficacy and prescription of exercise in pancreatic cancer is lacking. Well-designed trials, which have received feedback and input from key stakeholders prior to implementation, are required to examine the impact of exercise in pancreatic cancer on key cancer related health outcomes.

Download Full-text

The Relationship between Restless Legs Syndrome and Quality of Life in Patients with Myasthenia Gravis

European Neurology ◽

10.1159/000502002 ◽

2019 ◽

Vol 81 (3-4) ◽

pp. 205-208

Author(s):

Monica F. Ataide ◽

Carolina da Cunha-Correia ◽

Katia C.L. Petribú

Keyword(s):

Quality Of Life ◽

Myasthenia Gravis ◽

Restless Legs Syndrome ◽

Rating Scale ◽

Cross Sectional Study ◽

Cross Sectional ◽

Restless Legs ◽

Study Population ◽

Clinical Conditions

Background: Restless legs syndrome (RLS) is characterized for an uncomfortable sensation in legs and an irresistible desire to move them. This disorder has been more recently recognized in patients with myasthenia gravis (MG) and can interfere with the quality of life (QOL). Objectives: The aims of this study are to describe the prevalence of RLS and its severity and influence on the QOL in patients with MG. Method: This was a cross-sectional study conducted from May to June 2016 in Recife, Brazil. A sample of 42 patients was interviewed using a sociodemographic questionnaire, MG QOL questionnaire-15 and The RLS Rating Scale. Results: RLS was present in 47.6% of patients and of these 40.5% met moderate to severe RLS criteria. Patients were 45 years on average (SD ± 14.4) and women represented 57.1% of the study population. Among patients with RSL, the quality-of-life scores were worse (p = 0.010) on average. There was no association of RLS with the duration of MG, use of immunosuppressant or clinical conditions that could mimic the occurrence of RLS. Conclusion: RLS is a prevalent condition in patients with MG, and may be severe enough to negatively impact QOL.

Download Full-text