Assessment of induced rat mammary tumour response to chemotherapy using the apparent diffusion coefficient of tissue water as determined by diffusion-weighted H-NMR spectroscopy in vivo

1999 ◽  
Vol 8 (1) ◽  
pp. 20-26 ◽  
Author(s):  
L LEMAIRE ◽  
F HOWE ◽  
L RODRIGUES ◽  
J GRIFFITHS
Keyword(s):  
Diffusion Coefficient ◽  
Nmr Spectroscopy ◽  
Apparent Diffusion Coefficient ◽  
Tumour Response ◽  
Mammary Tumour ◽  
Tissue Water ◽  
H Nmr ◽  
Response To Chemotherapy ◽  
Apparent Diffusion

scholarly journals Assessment of the percentage of apparent diffusion coefficient value changes as an early indicator of the response of colorectal hepatic metastases to chemotherapy

2019 ◽  
Vol 50 (1) ◽  
Author(s):  
Nada Gamal El-Husseiny ◽  
Sayed Mohamed Mehana ◽  
Sherif Farouk El Zawawy
Keyword(s):  
Colorectal Cancer ◽  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Hepatic Metastasis ◽  
Percentage Increase ◽  
Early Assessment ◽  
Response To Chemotherapy ◽  
Significant Difference ◽  
Apparent Diffusion ◽  
Adc Values

Abstract Background Colorectal cancer is considered one of the most common causes of cancer-related deaths worldwide. We aim to evaluate the efficacy of DWI-MRI in predicting response to chemotherapy in this cohort. The study included 30 lesions in 20 biopsy proven-colorectal cancer patients with hepatic metastasis larger than 1 cm. All patients underwent both triphasic CT with intravenous contrast, pre-chemotherapy MRI (axial T2 and DW sequences) which was repeated 21 days following chemotherapy. A follow-up CT was done 2 months later. The response of the lesions was evaluated using the RESCIST criteria. On MRI, the lesions corresponding to the ones chosen on CT were identified and the apparent diffusion coefficient (ADC) values of pre- and post-chemotherapy images were recorded and correlated with the CT results. Results In the study, 17 (56.7%) of the lesions showed response to chemotherapy while 13 (43.3%) were non-responding. There was no significant difference in pretreatment ADC values between responding and non-responding lesions (p = 0.14). The mean percentage increase in ADC values in responding lesions was 42% compared to 18% in non-responding lesions (p < 0.001). Lesions that showed less than 18% increase were all found to be non-responsive Conclusion DWI-MRI has an emerging role in early assessment of early treatment response that can be detected before morphological response for patients with hepatic metastasis from colorectal cancer. Based on our study, the use of 25 % as the cutoff point of percent difference in ADC for detection of non-responding lesions proved to be successful only 21 days after the 1st chemotherapy cycle.

scholarly journals Rapid in vivo apparent diffusion coefficient mapping of hyperpolarized 13 C metabolites

2014 ◽  
Vol 74 (3) ◽  
pp. 622-633 ◽  
Author(s):  
Bertram L. Koelsch ◽  
Galen D. Reed ◽  
Kayvan R. Keshari ◽  
Myriam M. Chaumeil ◽  
Robert Bok ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Apparent Diffusion ◽  
Apparent Diffusion Coefficient Mapping

scholarly journals In vivo assessment of optimal b -value range for perfusion-insensitive apparent diffusion coefficient imaging

2012 ◽  
Vol 39 (8) ◽  
pp. 4832-4839 ◽  
Author(s):  
Moti Freiman ◽  
Stephan D. Voss ◽  
Robert V. Mulkern ◽  
Jeannette M. Perez-Rossello ◽  
Michael J. Callahan ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
B Value ◽  
Apparent Diffusion ◽  
Value Range ◽  
In Vivo Assessment

Slow diffusion of Ca2+ in the rat's hippocampus

1981 ◽  
Vol 59 (9) ◽  
pp. 1022-1025 ◽  
Author(s):  
M. E. Morris ◽  
K. Krnjević
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Time Course ◽  
Transport Number ◽  
Dorsal Hippocampus ◽  
Simple Diffusion ◽  
Apparent Diffusion ◽  
Resultant Increase ◽  
Simple Diffusion Model

Ca2+-sensitive microelectrodes, attached to CaCl2-containing micropipettes, were inserted into the dorsal hippocampus of rats under urethane. When Ca2+ was released iontophoretically, the amplitude and time course of the resultant increase in extracellular Ca2+ concentration could be fitted to a simple diffusion model, but the apparent diffusion coefficient of Ca2+ was only about 1/100 of its value in water, possibly because of reversible Ca2+ binding to hippocampal tissue. A further anomaly was a very low transport number (<0.01) for the release of Ca2+ from microelectrodes in vivo.

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