2.121 BROAD-BAND DIRECTIONAL EEG CONNECTIVITY CHANGES DURING MOTOR PREPARATION PREDICTS PARKINSON'S DISEASE SEVERITY

2012 ◽  
Vol 18 ◽  
pp. S106-S107
Author(s):  
J. Chiang ◽  
G. Tropini ◽  
Z.J. Wang ◽  
M.J. McKeown
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Severity ◽  
Broad Band ◽  
Motor Preparation ◽  
Eeg Connectivity

Treadmill exercise tests in persons with Parkinson’s disease: responses and disease severity

2015 ◽  
Vol 28 (5) ◽  
pp. 1009-1014 ◽  
Author(s):  
Mon S. Bryant ◽  
George R. Jackson ◽  
Jyhgong Gabriel Hou ◽  
Elizabeth J. Protas
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Severity ◽  
Treadmill Exercise ◽  
Exercise Tests

SNAP25 Gene Polymorphisms Protect Against Parkinson’s Disease and Modulate Disease Severity in Patients

2018 ◽  
Vol 56 (6) ◽  
pp. 4455-4463 ◽  
Author(s):  
Cristina Agliardi ◽  
Franca Rosa Guerini ◽  
Milena Zanzottera ◽  
Giulio Riboldazzi ◽  
Roberta Zangaglia ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Severity ◽  
Gene Polymorphisms

Stereopsis Deficits in Parkinson’s Disease and Their Clinical Implications

2020 ◽  
Author(s):  
Fang Ba ◽  
Tina T. Sang ◽  
Jaleh Fatehi ◽  
Wenjing He ◽  
Emanuel Mostofi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Severity ◽  
Rating Scale ◽  
Disease Status ◽  
Cognitive Status ◽  
Control Group ◽  
Motor Disorder ◽  
Healthy Control ◽  
Stereo Acuity

Abstract Background: Parkinson's disease (PD) is not exclusively a motor disorder. Among non-motor features, PD patients possess sensory visual dysfunctions. Stereopsis deficit can significantly impact patients' motor performance. However, it is not routinely tested, and its significance is under-investigated. Studying stereopsis using reliable 3D stimuli may help determine its implications in disease status in PD.The objective of the study is to investigate stereopsis abnormalities in PD with reliable and more physiological tools, and their correlation with indicators of PD severity. Methods: Twenty-four healthy control and 20 PD participants were first evaluated for visual acuity, visual field, contrast acuity, and stereoperception with 2D and Titmus stereotests, followed by the assessment with the 3D active shutter system. The correlation between stereopsis and disease severity, Unified Parkinson’s disease rating scale motor scores (UPDRS-III), levodopa equivalent daily dose (LEDD), course of disease and cognitive status were evaluated using univariate regression models. Results: Screening visual tests did not reveal any differences between PD and control group. With the 3D active shutter system, PD patients demonstrated significantly worse stereopsis (i.e p=0.002, 26 seconds of arc). There was a trend that UPDRS-III and LEDD negatively correlate with the stereo acuity, suggesting poorer stereoperception is related to disease severity. Preserved cognitive function correlated with more intact stereo acuity. Conclusion: With more reliable and physiological tools, PD patients exhibit poorer stereopsis. These deficits reflected PD motor and cognitive status. How stereopsis relates to gait, fall risks and navigation warrants more investigations in the future.

scholarly journals Profile of caregivers of Parkinson’s disease patients and burden measured by Zarit Scale Analysis of potential burden-generating factors and their correlation with disease severity

2018 ◽  
Vol 12 (3) ◽  
pp. 299-305 ◽  
Author(s):  
Paulo Eduardo Mestrinelli Carrilho ◽  
Marcelo Alvarez Rodrigues ◽  
Brenda Camila Reck de Oliveira ◽  
Emanuelle Bianchi da Silva ◽  
Taline Alisson Artemis Lazzarin Silva ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Severity ◽  
Linear Regression Analysis ◽  
Correlation Method ◽  
Cognitive Status ◽  
Multivariate Linear Regression Analysis ◽  
Pearson’S Correlation ◽  
Pearson's Correlation ◽  
Karnofsky Index

Abstract Parkinson’s disease (PD) promotes burden among patients and caregivers. Objective: To analyze whether disease severity (UPDRS and Karnofsky index), total disease duration, patient cognitive status (MMSE), presence of other diseases, patient age, socioeconomic conditions (ABEP2015), living together with patient, total time caregiving, weekly hours of care and presence of assistance from other caregivers are correlated with, and influence statistically, the degree of caregiver burden measured by the Zarit Burden Interview (ZBI). Methods: After ethics Committee approval, patients and respective caregivers were recruited. Following evaluation with the proper scales, all data were submitted to Pearson’s correlation method and multivariate linear regression analysis (ANOVA). Results: A total of 21 patients and respective caregivers were evaluated. 72% (N=15) of caregivers reported burden. One third of caregivers reported a moderate or severe level of burden. A cause-effect relationship could not be established by the statistical method adopted, but disease severity measured by the UPDRS was the sole variable showing statistically significant moderate positive Pearson’s correlation with ZBI (r=0.48, for p<0.05). On ANOVA, however, no independent variable had a statistically significant impact on ZBI scores. Conclusion: Despite our conflicting results, optimization of the available treatment, with better control of PD severity, can be considered an important element to effectively achieve the goal of reducing burden among caregivers.

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