44 High dose methotrexate followed by temozolomide plus concomitant radiation therapy in patients with newly diagnosed primary central nervous system Lymphoma: Preliminary results of a phase I dose escalation study

2010 ◽  
Vol 8 (4) ◽  
pp. 22-23 ◽  
Author(s):  
S. Manfrida ◽  
S. Chiesa ◽  
L. Teofili ◽  
B. Diletto ◽  
S. Hohaus ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Radiation Therapy ◽  
Phase I ◽  
Central Nervous System Lymphoma ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Newly Diagnosed ◽  
Dose Escalation Study ◽  
Dose Methotrexate

scholarly journals Radiation therapy for primary central nervous system lymphoma

2013 ◽  
Vol 7 (1) ◽  
pp. 4 ◽  
Author(s):  
Yuta Shibamoto
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Radiation Therapy ◽  
Systemic Chemotherapy ◽  
Central Nervous System Lymphoma ◽  
Current Status ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Dose Methotrexate ◽  
Treatment Volume

Up until the late 1970s, radiation therapy played an important role in the treatment of primary central nervous system lymphoma (PCNSL) but more recently its role has changed due to the increased use of systemic chemotherapy. In this article, the current status of radiotherapy for PCNSL and optimal forms of radiotherapy, including the treatment volume and radiation dose, are discussed. Data from nationwide Japanese surveys of PCNSL patients treated with radiation therapy suggest that the prognosis of PCNSL patients improved during the 1990s, in part due to the use of high-dose methotrexate-containing chemotherapy. The prognosis of patients treated with radiation alone also improved. Radiotherapy still seems to play an important role in the attempt to cure this disease.

scholarly journals Radiation therapy for primary central nervous system lymphoma

2013 ◽  
pp. e4
Author(s):  
Yuta Shibamoto
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Radiation Therapy ◽  
Systemic Chemotherapy ◽  
Central Nervous System Lymphoma ◽  
Current Status ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Dose Methotrexate ◽  
Treatment Volume

Up until the late 1970s, radiation therapy played an important role in the treatment of primary central nervous system lymphoma (PCNSL) but more recently its role has changed due to the increased use of systemic chemotherapy. In this article, the current status of radiotherapy for PCNSL and optimal forms of radiotherapy, including the treatment volume and radiation dose, are discussed. Data from nationwide Japanese surveys of PCNSL patients treated with radiation therapy suggest that the prognosis of PCNSL patients improved during the 1990s, in part due to the use of high-dose methotrexate-containing chemotherapy. The prognosis of patients treated with radiation alone also improved. Radiotherapy still seems to play an important role in the attempt to cure this disease.

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