High‐dose methotrexate monotherapy for newly diagnosed primary central nervous system lymphoma: 15‐year multicenter experience

2020 ◽  
Author(s):  
Wan‐Soo Yoon ◽  
Jae‐Sung Park ◽  
Young‐il Kim ◽  
Dong‐Sup Chung ◽  
Sin‐Soo Jeun ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Lymphoma ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Newly Diagnosed ◽  
Dose Methotrexate

scholarly journals ML-20 Outcome of high-dose methotrexate-based chemotherapy with or without Rituximab for primary central nervous system lymphoma

2020 ◽  
Vol 2 (Supplement_3) ◽  
pp. ii18-ii18
Author(s):  
Tatsuya Takezaki ◽  
Kazutaka Ota ◽  
Junichiro Kuroda ◽  
Naoki Shinojima ◽  
Yuki Takeshima ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Respiratory Infections ◽  
Central Nervous System Lymphoma ◽  
Infusion Reaction ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Newly Diagnosed ◽  
Dose Methotrexate

Abstract High-dose methotrexate based chemotherapy(HD-MTX) improved outcome of primary central nervous system lymphoma(PCNSL), but the prognosis is still poor. Recent studies showing that Rituximab is very effective for systemic lymphoma, the role of Rituximab for PCNSL is unclear. 34 patients diagnosed PCNSL received HD-MTX chemotherapy adding rituximab. Response rates were 74%(20/27) for newly diagnosed PCNSL patients, 85.7%(6/7) for recurrent PCNSL patients. Major side effects were infusion reaction and respiratory infections disease. We have to compare the outcome of HD-MTX chemotherapy retrospectively.

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