Similar increased serum dipeptidyl peptidase IV activity in chronic hepatitis C and other viral infections

2003 ◽  
Vol 27 (1) ◽  
pp. 59-68 ◽  
Author(s):  
T. Andrieu ◽  
V. Thibault ◽  
I. Malet ◽  
J. Laporte ◽  
B. Bauvois ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Viral Infections ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv

Are Chronic Hepatitis C Viral Infections More Benign in Patients With Hemophilia?

2007 ◽  
Vol 102 (8) ◽  
pp. 1672-1676 ◽  
Author(s):  
Nimer Assy ◽  
Norman Pettigrew ◽  
Sam S. Lee ◽  
Rabindra K. Chaudhary ◽  
J Johnston ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Viral Infections

scholarly journals Polymorphism in the Human Major Histocompatibility Complex and Early Viral Decline during Treatment of Chronic Hepatitis C

2008 ◽  
Vol 53 (2) ◽  
pp. 615-621 ◽  
Author(s):  
Leland J. Yee ◽  
KyungAh Im ◽  
Abdus S. Wahed ◽  
Teodorica Bugawan ◽  
Jia Li ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Viral Infections ◽  
Human Leukocyte ◽  
Random Coefficients ◽  
Rate Of Change ◽  
Hcv Infection ◽  
Human Major Histocompatibility Complex ◽  
Mhc Alleles

ABSTRACT The dynamics of the viral decline immediately after the start of therapy for chronic hepatitis C virus (HCV) infection may have prognostic potential for ultimate sustained virologic response. Considerable interindividual variability in the decline has been reported, including differences by race. The human major histocompatability complex (MHC) genes encode the human leukocyte antigens, which are important in the immune response to viral infections. We examined whether carriage of specific human MHC alleles are associated with the rate of the early viral decline. Longitudinal viral level data (baseline and days 1, 2, 7, 14, and 28 of treatment), medium resolution MHC genotyping, and random coefficients models were used to examine associations between MHC class I and class II allele carriage and the dynamics of the viral decline in 180 African-Americans (AAs) and 194 Caucasian Americans (CAs) with genotype-1 HCV infection over the first 28 days of treatment with peginterferon α2a plus ribavirin. Baseline viral levels were similar by race, irrespective of allele carriage. However, the rate of change in the viral decline was associated with both allele and race. Among the four subgroups defined by race and specific allele, the fastest rates of decline were observed (in terms of estimated mean viral declines log10 IU/ml during the first four weeks) in CA noncarriers for A*03 (2.75; P = 0.018), in CA carriers for Cw*03 (2.99; P = 0.046), and in CA noncarriers for DQA1*04 (2.66; P = 0.018) or DQB1*0402 (2.65; P = 0.018). MHC alleles are associated with the viral decline during the first 28 days of peginterferon therapy.

Autoantibodies present in chronic hepatitis c and chronic hepatitis B viral infections

Hepatology ◽  
1998 ◽  
Vol 27 (5) ◽  
pp. 1452-1452 ◽  
Author(s):  
David L. Smalley ◽  
Mary F. Hall ◽  
Clifford L. Broughton
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Chronic Hepatitis C ◽  
Chronic Hepatitis B ◽  
Viral Infections
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