Systematic monitoring for detection of atrial fibrillation in patients with acute ischaemic stroke (MonDAFIS): a randomised, open-label, multicentre study

2021 ◽  
Vol 20 (6) ◽  
pp. 426-436 ◽  
Author(s):  
Karl Georg Haeusler ◽  
Paulus Kirchhof ◽  
Claudia Kunze ◽  
Serdar Tütüncü ◽  
Cornelia Fiessler ◽  
...  
2017 ◽  
Vol 13 (8) ◽  
pp. 996-1002 ◽  
Author(s):  
Alis Heshmatollah ◽  
Puck Fransen ◽  
Olvert Berkhemer ◽  
Debbie Beumer ◽  
Aad van der Lugt ◽  
...  

2008 ◽  
Vol 17 ◽  
pp. S86-S87
Author(s):  
Martin Brown ◽  
William O’Brien ◽  
Tommy Wong ◽  
Maged Willaim ◽  
Scott Whyte ◽  
...  

2016 ◽  
Vol 116 (09) ◽  
pp. 410-416 ◽  
Author(s):  
Maurizio Paciaroni ◽  
Giancarlo Agnelli ◽  
Walter Ageno ◽  
Valeria Caso

SummaryIn patients with acute stroke and atrial fibrillation (AF), the risk of early recurrence has been reported to range between 0.1% and 1.3% per day. Anticoagulants are the most effective therapy for the prevention of recurrent ischaemic stroke in these patients, but randomised clinical trials have failed to produce any evidence supporting the administration of heparin within 48 hours from stroke onset as it has been associated with a non-significant reduction in the recurrence of ischaemic stroke, no substantial reduction in death and disability, and an increase in intracranial bleeding. As early haemorrhagic transformation is a major concern in the acute phase of stroke patients with AF, determining the optimal time to start anticoagulant therapy is essential. This review which focuses on the epidemiology of recurrent ischaemic stroke and haemorrhagic transformation in patients with acute ischaemic stroke and AF, proposes a model for decision making on optimal timing for initiating anticoagulation, based on currently available evidence.


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