scholarly journals 801. Targeting of Prostate Cancer Cells with the Novel Replication-Selective Adenoviral Mutant Adδδ in Combination with the Phytochemical Drugs Eqoul and Resveratrol

2011 ◽  
Vol 19 ◽  
pp. S306
The Prostate ◽  
2014 ◽  
Vol 75 (4) ◽  
pp. 360-369 ◽  
Author(s):  
William H. Gmeiner ◽  
Olcay Boyacioglu ◽  
Christopher H. Stuart ◽  
Jamie Jennings-Gee ◽  
K.C. Balaji

2017 ◽  
Vol 8 (1) ◽  
pp. 140-145 ◽  
Author(s):  
Luca Mologni ◽  
Vera Magistroni ◽  
Francesco Casuscelli ◽  
Marisa Montemartini ◽  
Carlo Gambacorti-Passerini

Cancers ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 289 ◽  
Author(s):  
Prashanth Nagesh ◽  
Pallabita Chowdhury ◽  
Elham Hatami ◽  
Vijaya Boya ◽  
Vivek Kashyap ◽  
...  

The therapeutic application of microRNA(s) in the field of cancer has generated significant attention in research. Previous studies have shown that miR-205 negatively regulates prostate cancer cell proliferation, metastasis, and drug resistance. However, the delivery of miR-205 is an unmet clinical need. Thus, the development of a viable nanoparticle platform to deliver miR-205 is highly sought. A novel magnetic nanoparticle (MNP)-based nanoplatform composed of an iron oxide core with poly(ethyleneimine)-poly(ethylene glycol) layer(s) was developed. An optimized nanoplatform composition was confirmed by examining the binding profiles of MNPs with miR-205 using agarose gel and fluorescence methods. The novel formulation was applied to prostate cancer cells for evaluating cellular uptake, miR-205 delivery, and anticancer, antimetastasis, and chemosensitization potentials against docetaxel treatment. The improved uptake and efficacy of formulations were studied with confocal imaging, flow cytometry, proliferation, clonogenicity, Western blot, q-RT-PCR, and chemosensitization assays. Our findings demonstrated that the miR-205 nanoplatform induces significant apoptosis and enhancing chemotherapeutic effects in prostate cancer cells. Overall, these study results provide a strong proof-of-concept for a novel nonviral-based nanoparticle protocol for effective microRNA delivery to prostate cancer cells.


2020 ◽  
Vol 203 ◽  
pp. e767
Author(s):  
Ryuta Watanabe* ◽  
Masashi Maekawa ◽  
Miki Hieda ◽  
Tomohiko Taguchi ◽  
Noriyoshi Miura ◽  
...  

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