Abstract #1131: Cribriform-Morular Variant of Papillary Thyroid Cancer: A Review of the Literature with Recommendations for Diagnosis and Management

Abstract Introduction: Brain metastases (BM) associated with papillary thyroid cancer (PTC) occur with an approximate frequency of 0.15% to 1.3% of PTC cases. There is little evidence regarding the treatment of this association (PTC and BM). A narrative review of the literature is presented. We assessed multiple treatment options and its effectiveness in this vulnerable population. Methods: The data were collected using the PubMed search engine and Google Scholar. There were selected all studies that included: << thyroid carcinoma >> << brain metastases >> << radiotherapy >> << surgery >> << iodine-131 >> << papillary carcinoma >> << differentiated carcinoma >>. Once the relevant works had been listed and compared, the main findings of each one were related and analyzed. Results: We found 15 studies between the years 1990 and 2019 that describe 187 patients with thyroid cancer and brain metastases; of which 138 presented PTC, and 62% (58/93) were women. The average age was 59 years. Patients who received multimodal treatment (association of 2 or more therapies; one of them, brain metastasis resection) had a longer survival, with an average of 54 months, compared to monotherapy. Discussion: Patients with PTC who also present BM require a multimodal therapy approach: when it is associated with brain metastasis resection, better results are evident; in contrast, when monotherapy is used, a limited performance is observed, with poor results. Conclusion: Patients with PTC who also present BM have better outcomes and higher survival rate with a multimodal therapy approach, including brain metastasis resection.

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Struma Ovarii with a focus of papillary thyroid cancer: a case report and review of the literature

Gynecologic Oncology ◽

10.1016/j.ygyno.2004.06.003 ◽

2004 ◽

Vol 94 (3) ◽

pp. 835-839 ◽

Cited By ~ 82

Author(s):

Samina Makani ◽

Wooshin Kim ◽

Arthur R. Gaba

Keyword(s):

Thyroid Cancer ◽

Case Report ◽

Papillary Thyroid Cancer ◽

Struma Ovarii ◽

Papillary Thyroid ◽

Review Of The Literature

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Autoimmune Rheumatic Disease (Polymyositis and Dermatomyositis) associated with Papillary Thyroid Carcinoma: Report of Two Cases and Review of the Literature

World Journal of Endocrine Surgery ◽

10.5005/jp-journals-10002-1127 ◽

2013 ◽

Vol 5 (2) ◽

pp. 55-58

Author(s):

Geeta Lal ◽

Anuradha R Bhama

Keyword(s):

Thyroid Cancer ◽

Papillary Thyroid Carcinoma ◽

Rheumatic Disease ◽

Thyroid Carcinoma ◽

Papillary Thyroid Cancer ◽

Papillary Thyroid ◽

Review Of The Literature ◽

Thyroid Resection ◽

Autoimmune Rheumatic Disease ◽

Metastatic Lung

ABSTRACT Autoimmune rheumatic diseases, such as polymyositis and dermatomyositis, have been demonstrated to carry a risk of the development of malignancy. Thyroid cancer is a rare occurrence in this setting; however, multiple cases have been reported. We present two cases of papillary thyroid carcinoma associated with dermatomyositis and polymyositis. The first patient is a 64-year-old female found to have papillary thyroid cancer after the diagnosis of polymyositis who underwent thyroid resection. The second patient is a 51-year-old male who was found to have synchronous papillary thyroid cancer and small cell carcinoma of the lung. He did not undergo thyroid resection due to widely metastatic lung cancer. We describe two cases of papillary thyroid cancer associated with autoimmune rheumatic disease. Though it is rare, thyroid cancer should remain in the differential diagnosis of a patient with new onset autoimmune rheumatic disease, as this may alter the eventual management of these patients. How to cite this article Lal G, Bhama AR. Autoimmune Rheumatic Disease (Polymyositis and Dermatomyositis) associated with Papillary Thyroid Carcinoma: Report of Two Cases and Review of the Literature. World J Endoc Surg 2013;5(2):55-58.

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