Marine Snail Toxin Approved to Treat Severe Pain

Abstract. Background: Arterial surgery for lower limb ischaemia is a frequently performed procedure in patients with severe cardio-pulmonary comorbidities, making them high-risk patients for acute postoperative complications with a need for prolonged stay in the post-anaesthesia care unit (PACU). However, detailed information on complications during the PACU stay is limited, hindering mechanism-based interventions for early enhanced recovery. Thus, we aimed to systematically describe acute complications and related risk factors in the immediate postoperative phase after infrainguinal arterial surgery. Patients and methods: Patients transferred to the PACU after infrainguinal arterial surgery due to chronic or acute lower limb ischaemia were consecutively included in a six-month observational cohort study. Pre- and intraoperative data included comorbidities as well as surgical and anaesthetic technique. Data on complications and treatments in the PACU were collected every 15 minutes using a standardised assessment tool. The primary endpoint was occurrence of predefined moderate or severe complications occurring during PACU stay. Results: In total, 155 patients were included for analysis. Eighty (52 %) patients experienced episodes with oxygen desaturation (< 85 %) and moderate or severe pain occurred in 72 patients (47 %); however, circulatory complications (hypotension, tachycardia) were rare. Preoperative opioid use was a significant risk factor for moderate or severe pain in PACU (59 vs. 38 % chronic vs. opioid naïve patients (P = 0.01). Conclusions: Complications in the PACU after infrainguinal arterial surgery relates to saturation and pain, suggesting that future efforts should focus on anaesthesia and analgesic techniques including opioid sparing regimes to enhance early postoperative recovery.

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Although high-intensity pain has been linked to adverse outcomes, many hospitalized patients report severe pain as acceptable

PsycEXTRA Dataset ◽

10.1037/e556302006-005 ◽

2004 ◽

Keyword(s):

High Intensity ◽

Severe Pain ◽

Hospitalized Patients ◽

Adverse Outcomes

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Results with short-term and long-term fiber restricted diet in therapy-resistant constipation with severe pain

Zeitschrift für Gastroenterologie ◽

10.1055/s-0030-1254752 ◽

2010 ◽

Vol 48 (05) ◽

Author(s):

J Czimmer ◽

I Szabó ◽

F Felföldi ◽

Á Vincze

Keyword(s):

Severe Pain ◽

Restricted Diet ◽

Short Term

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Diffusion Tensor Imaging reveals altered microstructural integrity along compressed L5 nerve roots in elderly stenosis patients with moderate to severe pain

10.26226/morressier.5ab3c880a874c6002655971c ◽

2018 ◽

Author(s):

Sam Hughes

Keyword(s):

Diffusion Tensor Imaging ◽

Severe Pain ◽

Diffusion Tensor ◽

Nerve Roots ◽

Microstructural Integrity

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Intranasal Fentanyl for the Treatment of Acute Severe Pain on the Pediatric Emergency Department of Mercy Hospital.

Case Medical Research ◽

10.31525/ct1-nct03912090 ◽

2019 ◽

Author(s):

Keyword(s):

Emergency Department ◽

Severe Pain ◽

Pediatric Emergency ◽

Pediatric Emergency Department ◽

Mercy Hospital

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Lumbar periarticular cysts of arcorray joint

Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery) ◽

10.33920/med-01-2003-06 ◽

2020 ◽

pp. 47-57

Author(s):

Anton Yarikov ◽

Maxim Shpagin ◽

Iliya Nazmeev ◽

Sergey Gorelov ◽

Olga Perlmutter

Keyword(s):

Minimally Invasive ◽

Severe Pain ◽

Pain Syndrome ◽

Long Term Results ◽

Lumbar Region ◽

Results Of Treatment ◽

Invasive Method ◽

Facet Syndrome

The immediate and long-term results of treatment of 30 patients with severe pain syndrome of the lumbar region, who underwent operations on denervation of DOS, were studied. The aim of the study was to evaluate the effectiveness of minimally invasive technologies for the treatment of pain in the lumbar region (denervation of DOS), to study the near and distant results of these treatment methods. Denervation DOS is an effective minimally invasive method for the treatment of facet syndrome caused by spondylarthrosis. It allows in the early and distant postoperative periods to significantly reduce the pain syndrome and improve the quality of life of patients.

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POSTOPERATIVE ANALGESIA IN ONCOLOGIC HOSPITAL: CURRENT STATUS AND PROSPECTS

Problems in oncology ◽

10.37469/0507-3758-2017-63-1-95-98 ◽

2017 ◽

Vol 63 (1) ◽

pp. 95-98

Author(s):

Aleksandr Potapov ◽

Anna Boyarkina ◽

Igor Kostyuk ◽

Sergey Ivanov ◽

Vsevolod Galkin

Keyword(s):

Postoperative Analgesia ◽

Severe Pain ◽

Rating Scale ◽

Numeric Rating Scale ◽

Current Status ◽

Regional Analgesia ◽

Surgical Pain ◽

Oncological Patients ◽

Maximum Pain ◽

Chronic Post Surgical Pain

Observational study of the postoperative analgesia efficacy with multimodal approach (acetaminophen, NSAIDs, opioids, regional analgesia) in 100 oncological patients has been conducted. On the first day after the surgery maximum pain level was 5 (3-7) points of numeric rating scale (NRS), 38% of patients experienced severe pain (NRS>6 points). After laparo-, thoracoscopic, videoassisted interventions and in cases of epidural analgesia NRS levels were 3 (1-6) and 3 (2-5) points respectively. After the surgeries with high risk of chronic post-surgical pain (thoracic, mammary gland interventions, Phan-nenstiel incision) NRS level was 6 (1-7) points. Patients in this group more often experienced severe pain than in the rest group - 56,7% vs. 32,5% (P.=0.037). Suggesting results of this study and data of current literature the perspectives of further improvement of postoperative analgesia in oncology have been formulated.

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