247 NT-proBNP levels and left atrial volumes in patients with isolated left ventricular diastolic dysfunction

2005 ◽  
Vol 4 (1) ◽  
pp. 52-52
Author(s):  
Kelley C. Stewart ◽  
John J. Charonko ◽  
Takahiro Ohara ◽  
William C. Little ◽  
Pavlos P. Vlachos

Diastolic dysfunction is the impairment of the filling in the left ventricle. Patients with left ventricular diastolic dysfunction (LVDD) lose the ability to adjust left ventricular filling properties without increasing left atrial pressure [1]. Although LVDD is very prevalent, it currently remains difficult to diagnose due to inherent atrioventricular compensatory mechanisms including increased heart rate, increased left ventricular (LV) contractility, and increased left atrial (LA) pressure. Although variations within the early diastolic filling velocity have been previously observed [2], the physical mechanism for the deceleration of the early filling wave is not understood.


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