Left Ventricular Vortex Ring Dynamics and Their Association to Early Diastolic Filling

2011 ◽  
Author(s):  
Kelley C. Stewart ◽  
John J. Charonko ◽  
Takahiro Ohara ◽  
William C. Little ◽  
Pavlos P. Vlachos
Keyword(s):  
Diastolic Dysfunction ◽  
Left Atrial ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Diastolic Filling ◽  
Compensatory Mechanisms ◽  
Ring Dynamics ◽  
Ventricular Diastolic Dysfunction ◽  
Ventricular Filling ◽  
Early Filling

Diastolic dysfunction is the impairment of the filling in the left ventricle. Patients with left ventricular diastolic dysfunction (LVDD) lose the ability to adjust left ventricular filling properties without increasing left atrial pressure [1]. Although LVDD is very prevalent, it currently remains difficult to diagnose due to inherent atrioventricular compensatory mechanisms including increased heart rate, increased left ventricular (LV) contractility, and increased left atrial (LA) pressure. Although variations within the early diastolic filling velocity have been previously observed [2], the physical mechanism for the deceleration of the early filling wave is not understood.

Investigation of the Relationship Between Color M-Mode Early Diastolic Propagation Velocity and Left Ventricular Adverse Pressure Gradients

2010 ◽  
Author(s):  
Kelley C. Stewart ◽  
Rahul Kumar ◽  
John J. Charonko ◽  
Pavlos P. Vlachos ◽  
William C. Little
Keyword(s):  
Heart Failure ◽  
Diastolic Dysfunction ◽  
Diastolic Heart Failure ◽  
Diagnostic Techniques ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Pressure Gradients ◽  
Compensatory Mechanisms ◽  
Ventricular Diastolic Dysfunction ◽  
The Relationship

Left ventricular diastolic dysfunction (LVDD) and diastolic heart failure are conditions that affect the filling dynamics of the heart and affect 36% of patients diagnosed with congestive heart failure [1]. Although this condition is very prevalent, it currently remains difficult to diagnose due to inherent atrio-ventricular compensatory mechanisms including increased heart rate, increased left ventricular (LV) contractility, and increased left atrial pressure (LA). A greater comprehension of the governing flow physics in the left ventricle throughout the introduction of the heart’s compensatory mechanisms has great potential to substantially increase the understanding of the progression of diastolic dysfunction and in turn advance the diagnostic techniques.

A Hydrodynamic Efficiency Parameter as a Novel Left Ventricular Diastolic Dysfunction Diagnostic Metric

2008 ◽  
Author(s):  
Kelley C. Stewart ◽  
Rahul Kumar ◽  
John J. Charonko ◽  
Pavlos P. Vlachos ◽  
William C. Little
Keyword(s):  
Diastolic Dysfunction ◽  
Critical Role ◽  
Propagation Speed ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Diastolic Filling ◽  
Ventricular Diastolic Dysfunction ◽  
Efficiency Parameter ◽  
Wave Propagation Speed ◽  
The Relationship

Numerous studies have shown that cardiac diastolic dysfunction and diastolic filling play a critical role in dictating overall cardiac health and demonstrated that the filling wave propagation speed is a significant index of the severity of diastolic dysfunction [1, 2]. However, the governing flow physics underlying the relationship between propagation speed and diastolic dysfunction are poorly understood. More importantly, currently there is no reliable metric to allow clinicians the ability to diagnose cardiac dysfunction on the basis of the wave filling speed.

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