Tu-P10:508 Leptin induces endothelin-1 gene expression via RAS/RAF/extracellular signal-regulated kinase pathway in rat aortic smooth muscle cells

2006 ◽  
Vol 7 (3) ◽  
pp. 296-297
Author(s):  
J.C. Liu ◽  
H.H. Chao ◽  
C.H. Chen ◽  
T.H. Cheng
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Extracellular Signal Regulated Kinase ◽  
Endothelin 1 ◽  
Extracellular Signal ◽  
Kinase Pathway

PDGF (alpha)-receptor is unresponsive to PDGF-AA in aortic smooth muscle cells from the NG2 knockout mouse

1999 ◽  
Vol 112 (6) ◽  
pp. 905-915 ◽  
Author(s):  
K.A. Grako ◽  
T. Ochiya ◽  
D. Barritt ◽  
A. Nishiyama ◽  
W.B. Stallcup
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Receptor Activation ◽  
Wild Type ◽  
Aortic Smooth Muscle Cells ◽  
Phenotypic Differences ◽  
Aortic Smooth Muscle ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal

A line of null mice has been produced which fails to express the transmembrane chondroitin sulfate proteoglycan NG2. Homozygous NG2 null mice do not exhibit gross phenotypic differences from wild-type mice, suggesting that detailed analyses are required to detect subtle alterations caused by the absence of NG2. Accordingly, dissociated cultures of aortic smooth muscle cells from null mice were compared to parallel cultures from wild-type mice for their ability to proliferate and migrate in response to specific growth factors. Both null and wild-type smooth muscle cells exhibited identical abilities to proliferate and migrate in response to PDGF-BB. In contrast, only the wild-type cells responded to PDGF-AA in both types of assays. NG2 null cells failed to proliferate or migrate in response to PDGF-AA, implying a defect in the signaling cascade normally initiated by activation of the PDGF (alpha)-receptor. In agreement with this idea, activation of the extracellular signal-regulated kinase (ERK) in response to PDGF-AA treatment occured only in wild-type cells. Failure to observe autophosphorylation of the PDGF (alpha)-receptor in PDGF-AA-treated null cells indicates that the absence of NG2 causes a defect in signal transduction at the level of (alpha)-receptor activation.

17β-Estradiol Downregulates Angiotensin-II-Induced Endothelin-1 Gene Expression in Rat Aortic Smooth Muscle Cells

2004 ◽  
Vol 11 (1) ◽  
pp. 27-36 ◽  
Author(s):  
Hong-Jye Hong ◽  
Ju-Chi Liu ◽  
Paul Chan ◽  
Shu-Hui Juan ◽  
Shih-Hurng Loh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Endothelin 1

17β-estradiol downregulates angiotensin-II-induced endothelin-1 gene expression in rat aortic smooth muscle cells

2004 ◽  
Vol 11 (1) ◽  
pp. 27-36 ◽  
Author(s):  
Hong-Jye Hong ◽  
Ju-Chi Liu ◽  
Paul Chan ◽  
Shu-Hui Juan ◽  
Shih-Hurng Loh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Endothelin 1 ◽  
17Β Estradiol

scholarly journals Uric acid stimulates endothelin-1 gene expression associated with NADPH oxidase in human aortic smooth muscle cells

2008 ◽  
Vol 29 (11) ◽  
pp. 1301-1312 ◽  
Author(s):  
Hung-hsing Chao ◽  
Ju-chi Liu ◽  
Jia-wei Lin ◽  
Cheng-hsien Chen ◽  
Chieh-hsi Wu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Uric Acid ◽  
Smooth Muscle ◽  
Nadph Oxidase ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Endothelin 1

Profiling of aortic smooth muscle cells gene expression during aging in rats

2006 ◽  
Vol 45 (3) ◽  
pp. e66
Author(s):  
Nadaud ◽  
Monnet ◽  
Louedec ◽  
Michel ◽  
Raoux ◽  
...  
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle
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