Cell and Molecular Responses to Hypoxic Stress

Author(s):  
Enb Ma ◽  
Gabriel G. Haddad
2008 ◽  
Vol 39 (01) ◽  
Author(s):  
R Trollmann ◽  
J Schneider ◽  
D Wenzel ◽  
W Rascher ◽  
O Ogunshola ◽  
...  

2016 ◽  
Author(s):  
Ana Feregrino-Perez ◽  
Sandra Jimenez-Garcia ◽  
Moises Vazquez-Cruz ◽  
Laura Mejia-Teniente ◽  
Ramon Guevara-Gonzalez ◽  
...  

2018 ◽  
Vol 23 (5-6) ◽  
pp. 347-370 ◽  
Author(s):  
Andy Wai Kan Yeung ◽  
Amr El-Demerdash ◽  
Ioana Berindan-Neagoe ◽  
Atanas G. Atanasov ◽  
Yuh-Shan Ho

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yanxia Zhan ◽  
Junxian Du ◽  
Zhihui Min ◽  
Li Ma ◽  
Wei Zhang ◽  
...  

AbstractHypoxia is a common phenomenon in solid tumors. The roles of exosomes from hypoxic breast cancer stroma are less studied. So, the study was aimed to investigate the role of exosomes from hypoxic cancer-associated fibroblasts (CAFs) cells in breast cancer. The circRNA array analysis was performed to screen differential expressed circRNAs between hypoxic and normoxic CAFs exosomes. Candidate circHIF1A (circ_0032138) was screened out and it was confirmed that circHIF1A was up-regulated in the exosomes from hypoxic CAFs and their exosomes. Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic CAFs exosomes transferred circHIF1A into breast cancer cells, which played an important role in cancer stem cell properties sponging miR-580-5p by regulating CD44 expression. In a summary, circHIF1A from hypoxic CAFs exosomes played an important role in stem cell properties of breast cancer. CircHIF1A may act as a target molecule of breast cancer therapy.


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