609 Elevated Lactate-dehydrogenase level and positive frozen section analysis are independent risk factors for positive final urethral margins at radical cystectomy

2012 ◽  
Vol 11 (1) ◽  
pp. e609-e609a ◽  
Author(s):  
T. Todenhöfer ◽  
M. Renninger ◽  
J. Mundhenk ◽  
M.F. Abdelhafez ◽  
A. Stenzl ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lactate Dehydrogenase ◽  
Radical Cystectomy ◽  
Frozen Section ◽  
Lactate Dehydrogenase Level ◽  
Frozen Section Analysis ◽  
Independent Risk Factors ◽  
Elevated Lactate ◽  
Elevated Lactate Dehydrogenase ◽  
Section Analysis

scholarly journals Risk Factors for Transformation to Higher-Grade Lymphoma and Its Impact on Survival in a Large Cohort of Patients With Marginal Zone Lymphoma From a Single Institution

2018 ◽  
Vol 36 (34) ◽  
pp. 3370-3380 ◽  
Author(s):  
Juan Pablo Alderuccio ◽  
Wei Zhao ◽  
Amrita Desai ◽  
Nicolas Gallastegui ◽  
Jeremy Ramdial ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lactate Dehydrogenase ◽  
Follicular Lymphoma ◽  
Lymphoid Tissue ◽  
Initial Treatment ◽  
Marginal Zone ◽  
Marginal Zone Lymphoma ◽  
Competing Risk ◽  
Elevated Lactate ◽  
Elevated Lactate Dehydrogenase

Purpose Given the paucity of data on higher-grade transformation (HGT) to aggressive lymphoma in patients with marginal zone lymphoma (MZL), we report on a large cohort of patients, identify risk factors, and determine HGT impact on overall survival (OS). Methods We analyzed 453 patients with biopsy-proven MZL seen at our institution between 1995 and 2016. Kaplan-Meier, Cox proportional hazards regression, and competing risk methods were used in analyses of time-to-event outcomes. Results Thirty-four patients (7.5%) had biopsy-proven HGT to diffuse large B-cell lymphoma, including seven (21%) diagnosed at the time of initial MZL diagnosis. Among 27 incident patients, median time to HGT was 29 months (range, 1.3 to 135 months). Higher risk of HGT was observed in those with nodal/splenic MZL (subdistribution hazard ratio [SHR], 2.60; P = .023). On multivariable competing risk analysis, elevated lactate dehydrogenase (SHR, 2.71), more than four nodal sites (SHR, 2.97), and failure to achieve complete remission (CR) after initial treatment (SHR, 3.76) conveyed significantly higher risk for HGT ( P < .02). International Prognostic Index (IPI), Follicular Lymphoma IPI, and Mucosa-Associated Lymphoid Tissue Lymphoma IPI were only significant predictors of HGT univariably. Patients with HGT had shorter OS (5-year rate, 65% v 86%; P < .001). Patients who presented with HGT within 12 months since MZL diagnosis had shorter OS than those with HGT at MZL diagnosis combined with those with HGT more than 12 months later (4-year rate, 43% v 81%, P < .001). Non-CR and higher scores of IPI, Follicular Lymphoma IPI, and Mucosa-Associated Lymphoid Tissue Lymphoma IPI were the main significant predictors for shorter progression-free survival and OS. Conclusion Failure to achieve CR after initial treatment, elevated lactate dehydrogenase, and more than four nodal sites at the time of MZL diagnosis are the main predictors of increased risk of HGT. Patients with HGT have shorter OS.

Significance of Cancer Involvement at the Ureteral Margin Detected on Routine Frozen Section Analysis during Radical Cystectomy

2006 ◽  
Vol 77 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Sang Eun Lee ◽  
Seok-Soo Byun ◽  
Sung Kyu Hong ◽  
In Ho Chang ◽  
Yong June Kim ◽  
...  
Keyword(s):  
Radical Cystectomy ◽  
Frozen Section ◽  
Frozen Section Analysis ◽  
Section Analysis

scholarly journals Can frozen-section analysis of ureteric margins at the time of radical cystectomy predict upper tract recurrence?

2020 ◽  
Vol 18 (3) ◽  
pp. 155-162
Author(s):  
Karim Soliman ◽  
Diaa-Eldin Taha ◽  
Omar M. Aboumarzouk ◽  
Islam Osama Koraiem ◽  
Ahmed A. Shokeir
Keyword(s):  
Radical Cystectomy ◽  
Frozen Section ◽  
Upper Tract ◽  
Frozen Section Analysis ◽  
Section Analysis

The value of frozen-section analysis of ureteric margins on surgical decision-making in patients undergoing radical cystectomy for bladder cancer

2007 ◽  
Vol 99 (1) ◽  
pp. 81-84 ◽  
Author(s):  
Yasser Osman ◽  
Nasr El-Tabey ◽  
Mohamed Abdel-Latif ◽  
Ahmed Mosbah ◽  
Noheir Moustafa ◽  
...  
Keyword(s):  
Decision Making ◽  
Bladder Cancer ◽  
Radical Cystectomy ◽  
Frozen Section ◽  
Surgical Decision ◽  
Frozen Section Analysis ◽  
Surgical Decision Making ◽  
Section Analysis

The clinical significance of intra-operative ureteral frozen section analysis at radical cystectomy for urothelial carcinoma of the bladder

2014 ◽  
Vol 33 (3) ◽  
pp. 359-365 ◽  
Author(s):  
Hyung Suk Kim ◽  
Kyung Chul Moon ◽  
Chang Wook Jeong ◽  
Cheol Kwak ◽  
Hyeon Hoe Kim ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Radical Cystectomy ◽  
Clinical Significance ◽  
Frozen Section ◽  
Frozen Section Analysis ◽  
Carcinoma Of The Bladder ◽  
Section Analysis
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