Functional benefits of kidney-preserving surgery in patients with high-risk upper tract urothelial cancer

2019 ◽  
Vol 18 (2) ◽  
pp. e2412
Author(s):  
M. Pikul ◽  
E.O. Stakhovsky ◽  
O.E. Stakhovsky ◽  
O.A. Voylenko ◽  
O.A. Kononenko ◽  
...  
Keyword(s):  
High Risk ◽  
Urothelial Cancer ◽  
Upper Tract ◽  
Upper Tract Urothelial Cancer

scholarly journals Incidence and Predictors of Secondary Upper Tract Urothelial Cancer in Patients with High-Risk Non-Muscle Invasive Urinary Bladder Cancer and its Impact on Imaging Surveillance: A Retrospective Analysis with 1501 Patients

2021 ◽  
Vol 2 (3) ◽  
pp. 151-157
Author(s):  
Ebrahim Elsaeed Abouelenein ◽  
Mohamed Elawdy ◽  
Diaa-Eldin Taha ◽  
Yasser Osman ◽  
Bedeir Ali-El Dein ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
High Risk ◽  
Urothelial Cancer ◽  
Multivariable Analysis ◽  
Bladder Tumors ◽  
Upper Tract ◽  
Upper Tract Urothelial Cancer ◽  
Imaging Surveillance ◽  
Muscle Invasive

Objectives: We aimed to study the incidence and predictors of upper tract urothelial cancer (UTUC) in patients with high-risk non-muscle invasive bladder cancer (HR-NMIBC). Methods: Patients who had HR-NMIBC were reviewed to identify those who subsequently developed UTUC. Complete transurethral resection was performed, and biopsies were collected for histopathology followed by intravesical chemoimmunotherapy. Patients were screened annually by computed tomography (CT) for UTUC. Results: Data for 1501 patients were reviewed. UTUC developed in 59 (4%) after a median of 20 months after HR-NMIBC. Most patients were symptomatic, but UTUC was discovered on routine follow-up imaging in 28%. On bivariate analysis, only multiple bladder tumors and the number of bladder recurrences were predictors for UTUC (P = 0.01 and P = 0.008, respectively). Multiple bladder tumors and ≥ 3 bladder recurrences remained significant on multivariable analysis. Conclusion: UTUC after HR-NMIBC is uncommon (4%). Despite routine follow-up CT imaging, recurrence was detected due to symptoms in most patients, and based on imaging only in 28%. Imaging surveillance can be prioritized in patients with multiple bladder tumors and those with ≥ 3 bladder recurrences. For the other patients, the benefit of imaging surveillance has to be weighed against the risks.

Flow Cytometric Bromodeoxyuridine/Deoxyribonucleic Acid Bivariate Analysis for Predicting Tumor Invasiveness of Upper Tract Urothelial Cancer

1994 ◽  
Vol 152 (1) ◽  
pp. 76-80 ◽  
Author(s):  
Ayako Miyakawa ◽  
Masaaki Tachibana ◽  
Jun Nakashima ◽  
Nobuhiro Deguchi ◽  
Shiro Baba ◽  
...  
Keyword(s):  
Urothelial Cancer ◽  
Deoxyribonucleic Acid ◽  
Bivariate Analysis ◽  
Upper Tract ◽  
Tumor Invasiveness ◽  
Flow Cytometric ◽  
Upper Tract Urothelial Cancer

Molecular subtypes of upper tract urothelial cancer: Setting the stage for precision therapy

Cancer Cell ◽  
2021 ◽  
Vol 39 (6) ◽  
pp. 745-747
Author(s):  
David J. McConkey ◽  
Nirmish Singla ◽  
Phillip Pierorazio ◽  
Kara Lombardo ◽  
Andres Matoso ◽  
...  
Keyword(s):  
Urothelial Cancer ◽  
Molecular Subtypes ◽  
Upper Tract ◽  
Precision Therapy ◽  
Upper Tract Urothelial Cancer ◽  
Cancer Setting

Therapy Approved for Hard-to-Treat Upper Tract Urothelial Cancer

JAMA ◽  
2020 ◽  
Vol 323 (19) ◽  
pp. 1887
Author(s):  
Rebecca Voelker
Keyword(s):  
Urothelial Cancer ◽  
Upper Tract ◽  
Upper Tract Urothelial Cancer
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