Differential effects of cyclosporine-A and tacroluimus on biliary bile acid metabolism and secretion in liver transplant recipients treated without steroids

2001 ◽  
Vol 33 ◽  
pp. A58
Author(s):  
Domenico Ombres ◽  
Sonia Gallo ◽  
Claudia Ciceron ◽  
Elena Torri ◽  
Antonio Araco ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Transplant ◽  
Cyclosporine A ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Transplant Recipients ◽  
Differential Effects ◽  
Biliary Bile Acid ◽  
Liver Transplant Recipients

Abstract 49: The Transcriptional Repressor MafG Regulates Cholesterol Catabolism

2015 ◽  
Vol 35 (suppl_1) ◽  
Author(s):  
Thomas Q de Aguiar Vallim ◽  
Elizabeth J Tarling ◽  
Hannah Ahn ◽  
Lee R Hagey ◽  
Casey E Romanoski ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Acid Metabolism ◽  
Metabolic Diseases ◽  
Cholesterol Metabolism ◽  
Transcriptional Repressor ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Bile Acid Metabolism ◽  
Biliary Bile Acid

Elevated circulating cholesterol levels is a major risk factor for cardiovascular diseases (CVD), and therefore understanding pathways that affect cholesterol metabolism are important for potential treatment of CVD. The major route for cholesterol excretion is through its catabolism to bile acids. Specific bile acids are also potent signaling molecules that modulate metabolic pathways affecting lipid, glucose and bile acid homeostasis. Bile acids are synthesized from cholesterol in the liver, and the key enzymes involved in bile acid synthesis ( Cyp7a1 , Cyp8b1 ) are regulated transcriptionally by the nuclear receptor FXR. We have identified an FXR-regulated pathway upstream of a transcriptional repressor that controls multiple bile acid metabolism genes. We identify MafG as an FXR target gene and show that hepatic MAFG overexpression represses genes of the bile acid synthetic pathway, and modifies the biliary bile acid composition. In contrast, MafG loss-of-function studies cause de-repression of the bile acid genes with concordant changes in biliary bile acid levels. Finally, we identify functional MafG response elements in bile acid metabolism genes using ChIP-Seq analysis. Our studies identify a molecular mechanism for the complex feedback regulation of bile acid synthesis controlled by FXR. The identification of this pathway will likely have important implications in metabolic diseases.

MDR-1 C3435T Polymorphism Influences Cyclosporine A Dose Requirement in Liver-Transplant Recipients

2004 ◽  
Vol 78 (1) ◽  
pp. 21-25 ◽  
Author(s):  
Laurence Bonhomme-Faivre ◽  
Aurore Devocelle ◽  
Faouzi Saliba ◽  
Skander Chatled ◽  
Jean Maccario ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Cyclosporine A ◽  
Transplant Recipients ◽  
Dose Requirement ◽  
C3435t Polymorphism ◽  
Liver Transplant Recipients ◽  
Mdr 1

In vitrocytokine responses in liver transplant recipients treated with cyclosporine A and tacrolimus

2009 ◽  
Vol 23 ◽  
pp. 83-91 ◽  
Author(s):  
Markus Golling ◽  
Mahmoud Sadeghi ◽  
Silvia Zipperle ◽  
Hamidreza Fonouni ◽  
Mohammad Golriz ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Cyclosporine A ◽  
Transplant Recipients ◽  
Liver Transplant Recipients
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