P-120 Stratification of Adults by Pericardial Fat Thickness Using Cardiovascular Magnetic Resonance: The Framingham Heart Study

2009 ◽  
Vol 4 ◽  
pp. S85
Author(s):  
Michael Chuang ◽  
Noriko Oyama ◽  
Philimon Gona ◽  
Carol J. Salton ◽  
Rahul R. Jhaveri ◽  
...  
Keyword(s):  
Cardiovascular Magnetic Resonance ◽  
Magnetic Resonance ◽  
Framingham Heart Study ◽  
Pericardial Fat ◽  
Heart Study ◽  
Fat Thickness

Abstract 3117: Subclinical Aortic Atherosclerosis by Cardiovascular Magnetic Resonance Imaging Predicts Increased Cardiovascular Morbidity and Mortality in an Initially Healthy Cohort: The Framingham Heart Study

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Michael L Chuang ◽  
Philimon Gona ◽  
Farouc A Jaffer ◽  
Carol J Salton ◽  
Kraig V Kissinger ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Magnetic Resonance ◽  
Magnetic Resonance ◽  
Framingham Heart Study ◽  
Plaque Burden ◽  
Rank Test ◽  
Black Blood ◽  
Aortic Atherosclerosis ◽  
Heart Study ◽  
Cardiovascular Morbidity And Mortality

INTRODUCTION: We sought to determine whether subclinical aortic atherosclerosis, detected noninvasively using cardiovascular magnetic resonance (CMR), predicts major adverse cardiovascular events (MACE) in adults without history or clinical manifestation of cardiovascular disease (CVD). METHODS: 318 Framingham Heart Study (FHS) Offspring cohort members (60±9 yrs, 51% women) underwent CMR in 1998–1999. Subjects were free of clinical CVD and were recruited from equal strata of age, sex and quintile of Framingham Coronary Risk score (FCRS), with double sampling of the top quintile. CMR of the descending aorta on a 1.5-T system used an ECG-triggered black-blood T2W TSE sequence with 1.03 × 0.64 × 5-mm 3 voxels, 10-mm gap. Aortic-lumen and plaque areas were hand-traced. MACE included CV death, myocardial infarction (MI), stroke or new heart failure (HF). A Cox proportional hazards model adjusted for FCRS was used to determine hazard ratio (HR) for MACE for the (within-sexes) quartile of subjects with greatest plaque burden (Q4) vs other subjects (Q1–3). Log-rank test was used to compare survival. RESULTS: CMR aortic atherosclerosis was identified in 38% of women and 41% of men. Over median 5.2-yr follow up, 38 MACE (4 deaths, 14 MIs, 12 strokes, 8 HF) occurred among 31 subjects. Greater plaque burden (Q4) was associated with 2.75-fold greater hazard of MACE (95% CI 1.33 – 5.69, p=0.007). The Figure shows Kaplan-Meier survival, log-rank p=0.0009. CONCLUSIONS: In a free-living population without history of cardiovascular disease, CMR evidence of subclinical aortic atherosclerosis was a predictor of 5-year MACE, even after adjustment for traditional cardiovascular risk factors.

Abstract 3574: Unsuspected Left Ventricular Wall Motion Abnormalities Identified by Cardiovascular Magnetic Resonance in a Free-Living Population: Lessons from the Framingham Heart Study

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Connie W Tsao ◽  
Philimon Gona ◽  
Carol J Salton ◽  
Peter G Danias ◽  
Susan Blease ◽  
...  
Keyword(s):  
Cardiovascular Magnetic Resonance ◽  
Magnetic Resonance ◽  
Framingham Heart Study ◽  
Wall Motion ◽  
Left Ventricular ◽  
Short Axis ◽  
Free Living ◽  
Heart Study ◽  
History Of ◽  
Wall Motion Abnormalities

INTRODUCTION: Resting left ventricular (LV) wall motion abnormalities (WMAs) are associated with significant morbidity and mortality. We hypothesized that unsuspected resting WMAs would be present in a healthy population and applied cardiovascular magnetic resonance (CMR) to characterize the prevalence of these in a free-living population. METHODS: 1794 subjects in the Framingham Heart Study Offspring Cohort (844M, 65±9 yrs) underwent cine CMR in short-axis, 2-ch, and 4-ch planes. Wall motion was scored using a standard 17-segment model with a 5-point scale. Global and regional (Ant, Sept, Inf, Lat) wall motion score indices (WMSI=wall motion score/# segments) were calculated with a WMSI>1 considered abnormal. LV ejection fraction (EF) and mass index (LVMI) were measured from the short axis stack. Adjudicated clinical events [CE; a history of coronary heart disease (CHD) or congestive heart failure (CHF)] were assessed. RESULTS: WMAs were present in 143 subjects. Compared to subjects with no prior CE, those with CE (n=157) had greater prevalence of WMA (Global, 34% vs 6%; Ant, 16% vs 2%; Sept, 18% vs 3%; Inf, 28% vs 4%; Lat, 27% vs 3%; all p<0.0001) and higher Framingham Risk Score (FRS) (11±3 vs 7±4, p<0.0001). In subjects with CE, WMA was associated with higher LVMI (70±14 g/m 2 vs 59±14 g/m 2 , p<0.0001) and lower EF (53±11% vs 69±6%, p<0.0001), but not age, blood pressure (BP), or FRS. Among 1637 subjects with no CE, 90 (5.5%) had a WMA. In these subjects, WMA was associated with greater age, BP, FRS, and LVMI, and lower EF (TABLE ). In the entire (n=1794) cohort, WMAs were more prevalent in men than in women (40% vs 19% with CE; 9% vs 3% without CE, respectively, both p<0.0001). CONCLUSIONS: In this closely followed free-living population, 5.5% of subjects have WMAs despite the absence of CE. WMAs were associated with other parameters of cardiovascular risk. The presence of WMAs among subjects without history of CHD or CHF may identify those at risk for adverse cardiovascular events.

scholarly journals Pericardial Fat is Associated With Atrial Conduction: The Framingham Heart Study

2014 ◽  
Vol 3 (2) ◽  
Author(s):  
Daniel J. Friedman ◽  
Na Wang ◽  
James B. Meigs ◽  
Udo Hoffmann ◽  
Joseph M. Massaro ◽  
...  
Keyword(s):  
Framingham Heart Study ◽  
Pericardial Fat ◽  
Heart Study

Abstract 5153: Pericardial Fat, Intra-Thoracic Fat, and Left Ventricular Mass: The Framingham Heart Study

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Caroline S Fox ◽  
Philimon Gona ◽  
Udo Hoffmann ◽  
Carol J Salton ◽  
Joseph Massaro ◽  
...  
Keyword(s):  
Left Ventricular Mass ◽  
Framingham Heart Study ◽  
Menopausal Status ◽  
Ct Scanning ◽  
Left Ventricular ◽  
Systemic Effects ◽  
Pericardial Fat ◽  
Ventricular Mass ◽  
Heart Study ◽  
Visceral Adipose

Pericardial fat is in direct anatomic contact with the myocardium and may lead to increased left ventricular mass (LVM). Whether the association of pericardial fat and LVM are independent of the systemic effects of obesity has not been fully explored. Participants from the Framingham Heart Study Offspring cohort (n=1006, mean age 60 years, 54% women) who underwent chest and abdominal computed tomography (CT) scanning and cine cardiac magnetic resonance imaging for left ventricular mass (LVM) quantification were included. CT scans were quantified for pericardial fat (fat within the pericardial sac), intra-thoracic fat (fat adherent to the heart but outside the pericardium), and abdominal visceral adipose tissue (VAT) using a volumetric method. Sex-specific multivariable linear regression was used to model the association of pericardial fat and of intra-thoracic fat with LVM after adjustment for age, smoking, alcohol use, menopausal status, systolic blood pressure, hypertension treatment, and height, and then additionally for VAT. Both pericardial and intra-thoracic fat were correlated with LVM in women (r=0.35, p<0.001 [pericardial fat]; r=0.37, p<0.001 [intra-thoracic fat]) and men (r=0.19, p<0.001 [pericardial fat]; r=0.17, p<0.001 [intra-thoracic fat]). In multivariable-adjusted models, both pericardial and intra-thoracic fat were associated with LVM (Table ). However, after adjusting for VAT, these associations were no longer significant (Table ). Both pericardial fat and intra-thoracic fat are associated with LVM in women and men. However, after accounting for VAT, a measure of systemic adiposity, neither pericardial fat nor intra-thoracic fat remain associated with LVM. These findings suggest that observed associations between pericardial fat and LVM are primarily due to the systemic effects of obesity. Beta coefficients of LVM (std error), per gram expressed per SD of pericardial/intra-thoracic fat

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