scholarly journals Induction of deletion mutation on ompR gene of Salmonella enterica serovar Typhi isolates from asymptomatic typhoid carriers to evolve attenuated strains for vaccine development

2014 ◽  
Vol 7 (12) ◽  
pp. 933-939 ◽  
Author(s):  
B Senthilkumar ◽  
K Anbarasu ◽  
D Senbagam ◽  
M Rajasekarapandian
Keyword(s):  
Salmonella Enterica ◽  
Vaccine Development ◽  
Deletion Mutation ◽  
Salmonella Enterica Serovar Typhi

scholarly journals Erratum Erratum to: Salmonella enterica serovar Typhi H58 clone has been endemic in Zimbabwe from 2012 to 2019

2021 ◽  
Author(s):  
Tapfumanei Mashe ◽  
Pimlapas Leekitcharoenphon ◽  
Sekesai Mtapuri-Zinyowera ◽  
Robert A Kingsley ◽  
V Robertson ◽  
...  
Keyword(s):  
Salmonella Enterica ◽  
Salmonella Enterica Serovar Typhi

scholarly journals First Canadian Salmonella enterica Serovar Typhi Isolate Harboring an Integron

2004 ◽  
Vol 48 (2) ◽  
pp. 689-690 ◽  
Author(s):  
Michael R. Mulvey ◽  
Shirley Brown ◽  
Philip Stuart ◽  
David Boyd ◽  
Lai-King Ng ◽  
...  
Keyword(s):  
Salmonella Enterica ◽  
Salmonella Enterica Serovar Typhi

The malS-5′UTR regulates hisG, a key gene in the histidine biosynthetic pathway in Salmonella enterica serovar Typhi

2017 ◽  
Vol 63 (4) ◽  
pp. 287-295 ◽  
Author(s):  
Ying Zhang ◽  
Dongmei Yan ◽  
Lin Xia ◽  
Xin Zhao ◽  
George Osei-Adjei ◽  
...  
Keyword(s):  
Salmonella Enterica ◽  
Rna Structure ◽  
Biosynthetic Pathway ◽  
Salmonella Typhi ◽  
Base Pairing ◽  
Salmonella Enterica Serovar Typhi ◽  
Cellular Processes ◽  
Invasive Capacity ◽  
Shine Dalgarno Sequence ◽  
Bax Gene

Bacterial noncoding RNAs (ncRNA) regulate diverse cellular processes, including virulence and environmental fitness. The malS 5′ untranslated region (named malS-5′UTR) was identified as a regulatory ncRNA that increases the invasive capacity of Salmonella enterica serovar Typhi. An IntaRNA search suggested base pairing between malS-5′UTR and hisG mRNA, a key gene in the histidine biosynthetic pathway. Overexpression of malS-5′UTR markedly reduced bacterial growth in minimal medium without histidine. Overexpression of malS-5′UTR increased mRNA from his operon genes, independently of the bax gene, and decreased HisG protein in Salmonella Typhi. RNA structure analysis showed base pairing of the malS-5′UTR RNA with the hisG mRNA across the ribosome binding site. Thus, we propose that malS-5′UTR inhibited hisG translation, probably by base pairing to the Shine–Dalgarno sequence.

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