Regulation of the gastrointestinal epithelial cell expression of CFTR protein by Salmonella enterica serovar Typhi, and its importance to infection and development of typhoid fever

2001 ◽  
Vol 120 (5) ◽  
pp. A706-A706
Author(s):  
J LYCZAK ◽  
G PIER
Keyword(s):  
Epithelial Cell ◽  
Typhoid Fever ◽  
Salmonella Enterica ◽  
Salmonella Enterica Serovar Typhi ◽  
Cftr Protein ◽  
Cell Expression

scholarly journals Highly Resistant Salmonella enterica Serovar Typhi with a NovelgyrAMutation Raises Questions about the Long-Term Efficacy of Older Fluoroquinolones for Treating Typhoid Fever

2012 ◽  
Vol 56 (5) ◽  
pp. 2761-2762 ◽  
Author(s):  
Kanika Deshpande Koirala ◽  
Duy Pham Thanh ◽  
Sudeep Dhoj Thapa ◽  
Amit Arjyal ◽  
Abhilasha Karkey ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Typhoid Fever ◽  
Treatment Failure ◽  
Salmonella Enterica ◽  
Systemic Infection ◽  
Resistant Isolate ◽  
Content Type ◽  
Salmonella Enterica Serovar Typhi ◽  
Term Efficacy

ABSTRACTAs a consequence of multidrug resistance, clinicians are highly dependent on fluoroquinolones for treating the serious systemic infection typhoid fever. While reduced susceptibility to fluoroquinolones, which lessens clinical efficacy, is becoming ubiquitous, comprehensive resistance is exceptional. Here we report ofloxacin treatment failure in typhoidal patient infected with a novel, highly fluoroquinolone-resistant isolate ofSalmonella entericaserovar Typhi. The isolation of this organism has serious implications for the long-term efficacy of ciprofloxacin and ofloxacin for typhoid treatment.

scholarly journals Typhoid Fever due to Extended Spectrum β-Lactamase-Producing Salmonella enterica Serovar Typhi: A Case Report and Literature Review

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Abdul Azeez Ahamed Riyaaz ◽  
Vindya Perera ◽  
Sabaratnam Sivakumaran ◽  
Nelun de Silva
Keyword(s):  
Case Report ◽  
Sri Lanka ◽  
Typhoid Fever ◽  
Salmonella Enterica ◽  
Salmonella Enterica Serovar Typhi ◽  
Extended Spectrum ◽  
Cephalosporin Resistance ◽  
Resistant Strains ◽  
Derivatives Of

Emergence of cephalosporin-resistant strains of Salmonella enterica serovar Typhi is a cause of concern in the management of enteric fever. Cephalosporin resistance in Salmonella species is mainly due to the production of extended-spectrum β-lactamases (ESBLs). The majority of ESBLs in Salmonella enterica serovar Typhi are derivatives of the TEM, SHV, and CTX-M β-lactamase families. Of these, CTX-M appears to be predominant. This paper discusses the detection and molecular characterization of an ESBL-producing Salmonella enterica serovar Typhi strain isolated from a patient who was admitted to a private hospital in Sri Lanka. The three main types of β-lactamases such as TEM, SHV, and CTX-M were identified in this isolate. This case report from Sri Lanka contributes to the knowledge of the increasingly reported cases of typhoid fever due to Salmonella enterica serovar Typhi resistant to β-lactamase by ESBL production.

scholarly journals The Salmonella enterica Serovar Typhi Type IVB Self-Association Pili Are Detached from the Bacterial Cell by the PilV Minor Pilus Proteins

2006 ◽  
Vol 74 (9) ◽  
pp. 5414-5418 ◽  
Author(s):  
Connie K. P. Tam ◽  
Christina Morris ◽  
Jim Hackett
Keyword(s):  
Typhoid Fever ◽  
Bacterial Cell ◽  
Salmonella Enterica ◽  
Enteric Fever ◽  
Dna Supercoiling ◽  
Bacterial Membrane ◽  
Salmonella Enterica Serovar Typhi ◽  
Protein Molecules ◽  
Dna Fragment ◽  
Self Association

ABSTRACT Salmonella enterica serovar Typhi and some strains (Vi+) of serovar Dublin use type IVB pili to facilitate bacterial self-association, but only when the PilV proteins (potential minor pilus proteins) are not synthesized. Pilus-mediated self-association may be important in the pathogenesis of enteric fever. We have shown previously that the extent of DNA supercoiling controls the rate of Rci-catalyzed inversion of a DNA fragment which includes the C-terminal portions of the PilV proteins. This inversion therefore controls PilV synthesis as a high inversion rate prohibits transcription of pilV-encoding DNA. Here, we describe the manner in which PilV protein expression inhibits bacterial self-association and present data which suggest that incorporation of one or a few PilV protein molecules into a growing pilus, comprised of PilS subunits, causes the pilus to detach at the bacterial membrane. The bacteria are then unable to self-associate. We suggest that this phenomenon may be relevant to the pathogenesis of typhoid fever.

scholarly journals Insights from the Genome Sequence of a Salmonella enterica Serovar Typhi Strain Associated with a Sporadic Case of Typhoid Fever in Malaysia

2012 ◽  
Vol 194 (18) ◽  
pp. 5124-5125 ◽  
Author(s):  
Kien-Pong Yap ◽  
Cindy Shuan Ju Teh ◽  
Ramani Baddam ◽  
Lay-Ching Chai ◽  
Narender Kumar ◽  
...  
Keyword(s):  
Typhoid Fever ◽  
Genome Sequence ◽  
Salmonella Enterica ◽  
Evolutionary Dynamics ◽  
Sporadic Case ◽  
Whole Genome Sequence ◽  
Whole Genome ◽  
Kuala Lumpur ◽  
Content Type ◽  
Salmonella Enterica Serovar Typhi

ABSTRACTSalmonella entericaserovar Typhi is the causative agent of typhoid fever, which causes nearly 21.7 million illnesses and 217,000 deaths globally. Herein, we describe the whole-genome sequence of theSalmonellaTyphi strain ST0208, isolated from a sporadic case of typhoid fever in Kuala Lumpur, Malaysia. The whole-genome sequence and comparative genomics allow an in-depth understanding of the genetic diversity, and its link to pathogenicity and evolutionary dynamics, of this highly clonal pathogen that is endemic to Malaysia.

Epithelial cell contact-induced alterations in Salmonella enterica serovar Typhi lipopolysaccharide are critical for bacterial internalization

2001 ◽  
Vol 3 (11) ◽  
pp. 763-772 ◽  
Author(s):  
Jeffrey B. Lyczak ◽  
Tanweer S. Zaidi ◽  
Martha Grout ◽  
Mauricio Bittner ◽  
Ines Contreras ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Salmonella Enterica ◽  
Cell Contact ◽  
Salmonella Enterica Serovar Typhi
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