Exacerbations in severe persistent asthma – Impact of risk factors control

2007 ◽  
Vol 13 (5) ◽  
pp. 675-689
Author(s):  
Diva Ferreira ◽  
Raquel Duarte ◽  
Aurora Carvalho
Keyword(s):  
Risk Factors ◽  
Persistent Asthma ◽  
Severe Persistent Asthma

Overview of severe asthma, with emphasis on pediatric patients: a review for practitioners

2021 ◽  
pp. jim-2020-001752
Author(s):  
Arabelle Abellard ◽  
Andrea A Pappalardo
Keyword(s):  
Risk Factors ◽  
Health Disparities ◽  
Severe Asthma ◽  
Pediatric Population ◽  
Asthma Management ◽  
Persistent Asthma ◽  
Individual Characteristics ◽  
Severe Persistent Asthma ◽  
The Usa ◽  
Life Threatening

Asthma is the most common life-threatening chronic disease in children. Although guidelines exist for the diagnosis and treatment of asthma, treatment of severe, pediatric asthma remains difficult. Limited studies in the pediatric population on new asthma therapies, complex issues with adolescence and adherence, health disparities, and unequal access to guideline-based care complicate the care of children with severe, persistent asthma. The purpose of this review is to provide an overview of asthma, including asthma subtypes, comorbidities, and risk factors, to discuss diagnostic considerations and pitfalls and existing treatments, and then present existing and emerging therapeutic approaches to asthma management. An improved understanding of asthma heterogeneity, clinical characteristics, inflammatory patterns, and pathobiology can help further guide the management of severe asthma in children. More studies are needed in the pediatric population to understand emerging therapeutics application in children. Effective multimodal strategies tailored to individual characteristics and a commitment to address risk factors, modifiers, and health disparities may help reduce the burden of asthma in the USA.

Association of Vitamin D Levels and Other Risk Factors with Asthma Exacerbations in Children

2020 ◽  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Persistent Asthma ◽  
Food Allergies ◽  
P Value ◽  
Serum Vitamin D ◽  
Asthma Exacerbations ◽  
Vitamin D Levels ◽  
Animal Dander

Background: The risk factors for asthma exacerbations are well understood. However, the effect of vitamin D levels on number of asthma exacerbations per year is not clearly studied. The objective of the study was to find out the association of serum vitamin D levels and asthma risk factors on asthma exacerbations. Methods: In this study, ninety-nine subjects from 5 to 15 years of age were recruited at an episode of acute exacerbation. It was a cross sectional study and carried out from 2012 to 2015. Pulmonary function test was done by spirometry. Asthma exacerbation was labeled when forced expiratory volume/ forced vital capacity (FEV1/FVC) ratio was less than 80% (American Thoracic Society). Global Initiative for Asthma (GINA) guidelines were used to classify asthma into mild, moderate and severe persistent asthma. Serum vitamin D levels were measured by chemiluminescence method. Pearson Chi-square test was applied and p value (p<0.05) was considered as statistically significant. Results: Children who had exposure to animal dander had significantly lower asthma exacerbations per year (p-value <0.046). There was no significant association between vitamin D levels and number of exacerbations per years (p-value <0.099). Asthma was prevalent in girls of low socioeconomic status (SES) compared to males. However, there was no significant association between smoke, exercise, home environment, food allergies, weather, pollen and dust with asthma exacerbations. Conclusion: Low levels of vitamin D were not associated with increased number of asthma exacerbations per year. However, children exposed to animal dander had lesser number of exacerbations per year (p-value <0.046). Keywords: Asthma; Vitamin D; Children; Exacerbations, Risk factors.

scholarly journals Are Operating Room Nurses at Higher Risk of Severe Persistent Asthma? The Nursesʼ Health Study

2013 ◽  
Vol 55 (8) ◽  
pp. 973-977 ◽  
Author(s):  
Nicole Le Moual ◽  
Raphaëlle Varraso ◽  
Jan Paul Zock ◽  
Paul Henneberger ◽  
Frank E. Speizer ◽  
...  
Keyword(s):  
Operating Room ◽  
Persistent Asthma ◽  
Health Study ◽  
Severe Persistent Asthma ◽  
Operating Room Nurses

Efficacy and safety of omalizumab in an Asian population with moderate-to-severe persistent asthma

Respirology ◽  
2009 ◽  
Vol 14 (8) ◽  
pp. 1156-1165 ◽  
Author(s):  
Ken OHTA ◽  
Terumasa MIYAMOTO ◽  
Taro AMAGASAKI ◽  
Manabu YAMAMOTO ◽  
Keyword(s):  
Persistent Asthma ◽  
Asian Population ◽  
Efficacy And Safety ◽  
Severe Persistent Asthma

Effect of asthma exacerbations on health care costs among asthmatic patients with moderate and severe persistent asthma

2012 ◽  
Vol 129 (5) ◽  
pp. 1229-1235 ◽  
Author(s):  
Jasmina I. Ivanova ◽  
Rachel Bergman ◽  
Howard G. Birnbaum ◽  
Gene L. Colice ◽  
Robert A. Silverman ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Costs ◽  
Persistent Asthma ◽  
Asthmatic Patients ◽  
Asthma Exacerbations ◽  
Severe Persistent Asthma ◽  
Care Costs

scholarly journals Bronchial thermoplasty for moderate or severe persistent asthma in adults

2014 ◽  
Author(s):  
Alfons Torrego ◽  
Ivan Solà ◽  
Ana Maria Munoz ◽  
Marta Roqué i Figuls ◽  
Juan Jose Yepes-Nuñez ◽  
...  
Keyword(s):  
Persistent Asthma ◽  
Bronchial Thermoplasty ◽  
Severe Persistent Asthma

Mite Molecular Profile in the Th2-Polarized Moderate-to-Severe Persistent Asthma Endotype Subjected to High Allergen Exposure

2020 ◽  
Vol 182 (1) ◽  
pp. 21-31
Author(s):  
Ruperto González-Pérez ◽  
Paloma Poza-Guedes ◽  
Fernando Pineda ◽  
Peter Forstenlechner ◽  
Miriam Castillo ◽  
...  
Keyword(s):  
Dominant Role ◽  
Persistent Asthma ◽  
Allergen Exposure ◽  
Molecular Signature ◽  
Molecular Profile ◽  
Serum Samples ◽  
Prick Test ◽  
Severe Persistent Asthma ◽  
Der P 1

<b><i>Background:</i></b> The association among the IgE responses to prevailing groups of house dust mite (HDM) allergens in the concurrent asthma phenotypes has not been determined. <b><i>Objective:</i></b> The aim of the present study lays on a component-resolved diagnosis (CRD) model to investigate the mite molecular signature in subjects with type-2 inflammation asthma. <b><i>Methods:</i></b> We selected patients showing a clinically relevant sensitization to HDMs with moderate-to-severe persistent asthma. Skin prick test (SPT) with standardized mite extracts, a broad customized CRD serum sIgE panel including 9 <i>Dermatophagoides pteronyssinus</i> allergens and the related protein allergenic characterization, was investigated in all serum samples. <b><i>Results:</i></b> Ninety out of 93 (96.77%) patients with a positive SPT to HDM showed a concordant sIgE (≥0.35 kU<sub>A</sub>/L) to the crude extract of <i>D. pteronyssinus</i>. Major allergens (Der p 2, Der p 23, and Der p 1) were present in &#x3e;70% of all subjects, with mid-tier allergens (Der p 5, Der p 7, and Der p 21) reaching up to 51% in the present cohort. A complex pleomorphic repertoire of HDM molecules recognized by IgE was depicted, including 38 distinct profiles. <b><i>Conclusions and Clinical Relevance:</i></b> The proposed CRD panel approach, containing the most prevalent HDM allergens, appeared to be sufficient to obtain a precise <i>D. pteronyssinus</i> molecular diagnosis in asthmatics with a climate-dependent high-mite allergen exposure and coexisting sensitization. A dominant role of both major and mid-tier allergens has been confirmed in moderate and severe persistent asthmatics with the preponderant Th2-high endotype.

Sign in / Sign up

Export Citation Format

Share Document