Effect of dapagliflozin on urinary albumin excretion in patients with chronic kidney disease with and without type 2 diabetes: a prespecified analysis from the DAPA-CKD trial

Author(s):  
Niels Jongs ◽  
Tom Greene ◽  
Glenn M Chertow ◽  
John J V McMurray ◽  
Anna Maria Langkilde ◽  
...  
2017 ◽  
Vol 13 (6) ◽  
pp. 592.e1-592.e7 ◽  
Author(s):  
Romaine de Sépibus ◽  
François Cachat ◽  
Blaise J. Meyrat ◽  
Gezim Dushi ◽  
Ariane Boubaker ◽  
...  

Diabetes Care ◽  
2007 ◽  
Vol 30 (7) ◽  
pp. 1886-1888 ◽  
Author(s):  
M. Fukui ◽  
H. Ose ◽  
I. Nakayama ◽  
H. Hosoda ◽  
M. Asano ◽  
...  

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Hidenori Hirukawa ◽  
Shinji Kamei ◽  
Tomohiko Kimura ◽  
Atsushi Obata ◽  
Kenji Kohara ◽  
...  

It is very important to explore how we can reduce urinary albumin excretion which is an independent risk factor for ischemic heart disease. In this study, we retrospectively evaluated the effects of RAS inhibitor therapy on diabetic nephropathy in Japanese subjects whose urinary albumin levels were within normal range. We enrolled 100 subjects with type 2 diabetes who did not take any renin-angiotensin system (RAS) inhibitor. We defined the subjects taking RAS inhibitor for more than 3 years as RAS inhibitor group. RAS inhibitor exerted protective effect on the progression of urinary albumin excretion in subjects with type 2 diabetes without diabetic nephropathy. In addition, RAS inhibitor exerted more protective effects on renal function especially in subjects with poor glycemic control. In conclusion, RAS inhibitor could protect renal function against the deleterious effect of chronic hyperglycemia in Japanese subjects with type 2 diabetes even before the onset of diabetic nephropathy.


2018 ◽  
Vol 33 (suppl_1) ◽  
pp. i27-i27
Author(s):  
Peter Rossing ◽  
Geoffrey Block ◽  
Glenn Chertow ◽  
Melanie Chin ◽  
Angie Goldsberry ◽  
...  

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