Imaging bone-marrow activity with 18 F-fluorothymidine PET

AbstractRecent studies have revealed an inverse association between height and cardiovascular disease. However, the background mechanism of this association has not yet been clarified. Height has also been reported to be positively associated with cancer. Therefore, well-known cardiovascular risk factors, such as increased oxidative stress and chronic inflammation, are not the best explanations for this inverse association because these risk factors are also related to cancer. However, impaired blood flow is the main pathological problem in cardiovascular disease, while glowing feeding vessels (angiogenesis) are the main characteristic of cancer pathologies. Therefore, endothelial maintenance activity, especially for the productivity of hematopoietic stem cells such as CD34-positive cells, could be associated with the height of an individual because this cell contributes not only to the progression of atherosclerosis but also to the development of angiogenesis. In addition, recent studies have also revealed a close connection between bone marrow activity and endothelial maintenance; bone marrow-derived hematopoietic stem cells contribute towards endothelial maintenance. Since the absolute volume of bone marrow is positively associated with height, height could influence endothelial maintenance activity. Based on these hypotheses, we performed several studies. The aim of this review is not only to discuss the association between height and bone marrow activity, but also to describe the potential mechanism underlying endothelial maintenance. In addition, this review also aims to explain some of the reasons that implicate hypertension as a major risk factor for stroke among the Japanese population. The review also aims to clarify the anthropological reasons behind the high risk of atherosclerosis progression in Japanese individuals with acquired genetic characteristics.

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Assessing Bone Marrow Activity in Patients with Myelofibrosis: Results of a Pilot Study of18F-FLT PET

Journal of Nuclear Medicine ◽

10.2967/jnumed.116.188508 ◽

2017 ◽

Vol 58 (10) ◽

pp. 1603-1608 ◽

Cited By ~ 7

Author(s):

Laetitia Vercellino ◽

Matthieu John Ouvrier ◽

Emmanuelle Barré ◽

Bruno Cassinat ◽

Virginie de Beco ◽

...

Keyword(s):

Bone Marrow ◽

Pilot Study ◽

Flt Pet ◽

Marrow Activity

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Effect of Extra-corporeal Irradiation of the Blood on Bone Marrow Activity in Acute Leukaemia

Nature ◽

10.1038/221972a0 ◽

1969 ◽

Vol 221 (5184) ◽

pp. 972-974 ◽

Cited By ~ 18

Author(s):

B. W. B. CHAN ◽

F. G. J. HAYHOE ◽

J. A. BULLIMORE

Keyword(s):

Bone Marrow ◽

Acute Leukaemia ◽

Marrow Activity

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Effect of Phenylhydrazine and Bone Marrow Inhibitors on Red Cell Destruction and Serum Iron Concentration

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1958.193.1.92 ◽

1958 ◽

Vol 193 (1) ◽

pp. 92-94

Author(s):

Alfred Chanutin

Keyword(s):

Bone Marrow ◽

Serum Iron ◽

Iron Concentration ◽

Hemoglobin Concentration ◽

Moderate Increase ◽

Serum Iron Concentration ◽

Moderate Anemia ◽

Sublethal Doses ◽

Slight Depression ◽

Marrow Activity

The administration of sublethal doses of bone marrow depressants (nitrogen mustard, triethylene melamine and thioguanine) causes a temporary, moderate increase in serum iron concentration, a slight depression of bone marrow activity and no change in hemoglobin concentration. A combination of any of these drugs with a small dose of phenylhydrazine causes a temporary marked hyperferremia, a moderate anemia and a marked reticulocytosis. The results indicate that hyperferremia is not necessarily associated with bone marrow activity.

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Effect of Transfusion Polycythemia upon Bone Marrow Activity and Erythrocyte Survival in Man

Blood ◽

10.1182/blood.v6.11.1021.1021 ◽

1951 ◽

Vol 6 (11) ◽

pp. 1021-1033 ◽

Cited By ~ 25

Author(s):

FREDERICK ROSS BIRKHILL ◽

MARY A. MALONEY ◽

STANLEY M. LEVENSON

Keyword(s):

Bone Marrow ◽

Cell Mass ◽

White Blood Cells ◽

Red Cell ◽

Adult Males ◽

Erythrocyte Survival ◽

Red Cell Mass ◽

Post Infusion ◽

Cell Synthesis ◽

Marrow Activity

Abstract 1. The effect of transfusion polycythemia upon bone marrow activity and erythrocyte survival has been studied in 4 normal young adult males. 2. Plasma volumes did not change significantly throughout the period of study. 3. Total red cell masses increased to the "expected" levels, i.e., to the total of the subjects’ cells plus the transfused cells immediately after the transfusions. Thereafter these fell progressively, reaching the control levels in about forty days. 4. Survival of the infused cells was normal. 5. The subjects’ own red cell masses fell progressively at first. This was due to decreased erythropoiesis rather than to increased destruction. This is indicated by (a) no consistent significant elevation in hemolytic indexes; (b) change of the myeloid-erythroid ratio from normal values of 4 to 7:1 to about 20:1 two weeks post-infusion; (c) consistent decrease in circulating reticulocytes. 6. The depression of erythropoiesis was directly related to the quantity of red cells infused; almost complete cessation of red cell synthesis followed an increase of the red cell mass by forty per cent. 7. The depression of erythropoiesis was only temporary. As soon as the total circulating red cell mass returned to the pre-injection level, erythropoiesis proceeded at a normal rate. 8. No consistent changes in the circulating white blood cells, totals and differentials were noted. 9. Mild abnormalities in some liver functions were observed. Whether these should be attributed to the effects of the transfusions directly, or to the mild febrile responses experienced by the subjects shortly after the infusions cannot be stated with certainty at present.

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Focal Bone Marrow Activity

Clinical Nuclear Medicine ◽

10.1097/00003072-198504000-00018 ◽

1985 ◽

Vol 10 (4) ◽

pp. 295-296 ◽

Cited By ~ 1

Author(s):

DAVID M. ROWE ◽

DONALD S. SCHAUWECKER ◽

HEE-MYUNG PARK

Keyword(s):

Bone Marrow ◽

Marrow Activity

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Effect of radiotherapy and chemotherapy on bone marrow activity

Nuclear Medicine Communications ◽

10.1097/mnm.0b013e328340798c ◽

2011 ◽

Vol 32 (1) ◽

pp. 17-22 ◽

Cited By ~ 15

Author(s):

Ali Agool ◽

Riemer H.J.A. Slart ◽

Kristin K. Thorp ◽

Andor W.J.M. Glaudemans ◽

David C.P. Cobben ◽

...

Keyword(s):

Bone Marrow ◽

Marrow Activity

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Intercostal Muscle Contraction or Rib Bone Marrow Activity?

Clinical Nuclear Medicine ◽

10.1097/rlu.0b013e318126c00a ◽

2007 ◽

Vol 32 (9) ◽

pp. 739-740 ◽

Cited By ~ 3

Author(s):

Sandip Basu ◽

Saad Alzeair ◽

Geming Li ◽

Hongming Zhuang ◽

Abass Alavi

Keyword(s):

Bone Marrow ◽

Muscle Contraction ◽

Intercostal Muscle ◽

Marrow Activity

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Res Scintigraphy in Polycythemia Vera and Secondary or Relative Polycythemia

Acta Radiologica ◽

10.1177/028418519303400216 ◽

1993 ◽

Vol 34 (2) ◽

pp. 183-186 ◽

Cited By ~ 3

Author(s):

U. Rudberg ◽

K.-O. Skårberg

Keyword(s):

Bone Marrow ◽

Polycythemia Vera ◽

Reticuloendothelial System ◽

Pelvic Bone ◽

Splenic Size ◽

Degree Of Extension ◽

Marrow Activity

Scintigraphy of the reticuloendothelial system (RES) was performed in 19 patients with polycythemia vera (PCV) and in 18 with secondary or relative polycythemia (PS). Bone marrow extension was found in all patients with PCV and in 11 of 18 patients with PS. The patients with PCV had a higher degree of extension than those with PS. Increased pelvic bone marrow activity was found in 16 of 19 PCV patients, but in none with PS. Splenomegaly was found in 9 patients with PCV, and in none with PS. It is concluded that RES scintigraphy in the majority of patients may differentiate between PCV and PS using the parameters pelvic bone marrow activity, bone marrow extension and splenic size.

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