Intravenous induction agents

2012 ◽  
pp. 227-232 ◽  
Author(s):  
Aakash Agarwala ◽  
Mark Dershwitz
Keyword(s):  
1994 ◽  
Vol 165 (4) ◽  
pp. 506-509 ◽  
Author(s):  
Christopher F. Fear ◽  
Carl S. Littlejohns ◽  
Eryl Rouse ◽  
Paul McQuail

BackgroundThe induction agent propofol is known to reduce electroconvulsive therapy (ECT) seizure duration. It is assumed that outcome from depression is adversely affected by this agent. This study compares propofol and methohexitone as induction agents for ECT.MethodIn a prospective, randomised, double-blind study 20 subjects with major depressive disorder (DSM-III-R criteria) received propofol or methohexitone anaesthesia. The Hamilton Depression Rating Scale and Beck Depression Inventory were used to assess depression before therapy, at every third treatment, and at the end of therapy. Seizure duration was measured using the cuff technique.ResultsMean seizure durations (P < 0.01) and mean total seizure duration (P < 0.01) were shorter in the propofol group. There was no difference in outcome.ConclusionsUse of propofol may not adversely affect outcome from depression and it is not necessarily contraindicated as an induction agent for ECT. Our results should be interpreted cautiously, and larger studies are needed.


1965 ◽  
Vol 37 (6) ◽  
pp. 415-421 ◽  
Author(s):  
R.S.J. CLARKE ◽  
M.J. KIRWAN ◽  
J.W. DUNDEE ◽  
D.W. NEILL ◽  
E.S. MITCHELL

Author(s):  
Naama Steiner ◽  
Jacob Ruiter-Ligeti ◽  
Russell Frank ◽  
Maryam Al Shatti ◽  
Ahmad Badeghiesh ◽  
...  

1968 ◽  
Vol 47 (2) ◽  
pp. 171???173 ◽  
Author(s):  
DAVID W. BARRON

2002 ◽  
Vol 26 (12) ◽  
pp. 455-457 ◽  
Author(s):  
Allan Scott ◽  
Harold Boddy

Aims and MethodTo compare methohexitone and propofol in electroconvulsive therapy (ECT). A retrospective within-subject comparison was made of the use of these drugs in separate courses of bilateral ECT in one clinic over 10 years. Patients taking mood stabilising or anti-epileptic drugs were excluded. The initial seizure threshold and seizure duration were of particular interest.ResultsThe median initial seizure thresholds were identical (75 mC). The median initial seizure duration with threshold stimulation was 25% shorter with propofol (21v.28 s). The median total numbers of treatments in the courses were identical (eight treatments).Clinical ImplicationsThe shorter seizure duration observed with propofol was not associated with a commensurate rise in the initial seizure threshold. The shorter seizure duration may therefore have no effect on the therapeutic efficacy of treatment.


Author(s):  
K.E. Joubert

A survey of the routine anaesthetic management of dogs and cats during sterilisation by veterinarians in South Africa was conducted. This report describes the premedication, induction and maintenance agents most commonly used in dogs and cats. Information about monitoring of patients during the procedure and who is responsible for induction of anaesthesia and monitoring was obtained. Questionnaires were analysed with regard to demographic data, practice size, continuing education, the number of surgical procedures and sterilisations performed per week and an estimate of yearly mortality. Acetylpromazine is the most commonly used premedication in dogs and xylazine in cats. Thiopentone in dogs and alphaxalone/alphadolone in cats were the induction agents most commonly used. Alphaxalone/alphadolone in cats and halothane in dogs are the most commonly used maintenance agents. Records of anaesthesia are poorly kept and monitoring of patients is poorly performed. Respiratory rate is the parameter most commonly monitored (90.7 %), and in most cases is the sole parameter. On average 10.34 ± 8.25 cats were operated per week, of which 5.45 ±5.60 were sterilised; 17.79 ±11.61 dogs were operated per week, of which 8.65 ±7.10 were sterilised. In total, 190 patients died under anaesthesia, a mortality rate of 1:1243. Just over 50 % of practitioners had attended continuing education courses during their careers.


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