Mitochondrial DNA variation in eastern highlanders of Papua New Guinea

Human genetics of the Kula Ring: Y-chromosome and mitochondrial DNA variation in the Massim of Papua New Guinea

European Journal of Human Genetics ◽

10.1038/ejhg.2014.38 ◽

2014 ◽

Vol 22 (12) ◽

pp. 1393-1403 ◽

Cited By ~ 8

Author(s):

Mannis van Oven ◽

Silke Brauer ◽

Ying Choi ◽

Joe Ensing ◽

Wulf Schiefenhövel ◽

...

Keyword(s):

Mitochondrial Dna ◽

Y Chromosome ◽

Papua New Guinea ◽

Human Genetics ◽

New Guinea ◽

Dna Variation

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Tree kangaroo molecular systematics based on partial cytochrome b sequences: are Matschie's tree kangaroo (Dendrolagus matschiei) and Goodfellow's tree kangaroo (D. goodfellowi buergersi) sister taxa?

Australian Mammalogy ◽

10.1071/am10017 ◽

2012 ◽

Vol 34 (1) ◽

pp. 18 ◽

Cited By ~ 3

Author(s):

Thomas J. McGreevy ◽

Lisa Dabek ◽

Thomas P. Husband

Keyword(s):

Mitochondrial Dna ◽

Papua New Guinea ◽

Cytochrome B ◽

Molecular Systematics ◽

Phylogenetic Analyses ◽

New Guinea ◽

Critically Endangered ◽

Evolutionary Relationships ◽

Accurate Identification ◽

Identification Of Species

New Guinea tree kangaroos (Dendrolagus spp.) are unique arboreal macropodid marsupials mainly listed as critically endangered or endangered. The molecular systematics of Dendrolagus has not been fully resolved and is critical for the accurate identification of species and their evolutionary relationships. Matschie’s tree kangaroo (D. matschiei) and Goodfellow’s tree kangaroo (D. goodfellowi buergersi) share numerous morphological, physiological, and behavioural traits. We analysed the partial mitochondrial DNA cytochrome b gene for D. matschiei (n = 67), D. g. buergersi (n = 8), D. goodfellowi unidentified ssp. (n = 8), golden-mantled tree kangaroo (D. g. pulcherrimus; n = 1), and two additional New Guinea Dendrolagus taxa to determine whether D. matschiei and D. g. buergersi are sister taxa. D. matschiei and D. g. buergersi were not placed as sister taxa in our phylogenetic analyses; however, we were unable to analyse a known sample from a D. g. goodfellowi. We found initial genetic evidence that D. matschiei and the Lowland tree kangaroo (D. spadix) are sister taxa – they may have diverged after the formation of the Huon Peninsula of Papua New Guinea. Our results also support the elevation of D. g. pulcherrimus to a full species. An improved understanding of Dendrolagus molecular systematics will contribute substantially to their conservation.

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Geographic variation in human mitochondrial DNA from Papua New Guinea.

Genetics ◽

10.1093/genetics/124.3.717 ◽

1990 ◽

Vol 124 (3) ◽

pp. 717-733 ◽

Cited By ~ 5

Author(s):

M Stoneking ◽

L B Jorde ◽

K Bhatia ◽

A C Wilson

Keyword(s):

Mitochondrial Dna ◽

High Resolution ◽

Papua New Guinea ◽

Statistical Significance ◽

New Guinea ◽

Human Populations ◽

Restriction Maps ◽

Population Movements ◽

Human Mitochondrial Dna ◽

Mtdna Variation

Abstract High resolution mitochondrial DNA (mtDNA) restriction maps, consisting of an average of 370 sites per mtDNA map, were constructed for 119 people from 25 localities in Papua New Guinea (PNG). Comparison of these PNG restriction maps to published maps from Australian, Caucasian, Asian and African mtDNAs reveals that PNG has the lowest amount of mtDNA variation, and that PNG mtDNA lineages originated from Southeast Asia. The statistical significance of geographic structuring of populations with respect to mtDNA was assessed by comparing observed GST values to a distribution of GST values generated by random resampling of the data. These analyses show that there is significant structuring of mtDNA variation among worldwide populations, between highland and coastal PNG populations, and even between two highland PNG populations located approximately 200 km apart. However, coastal PNG populations are essentially panmictic, despite being spread over several hundred kilometers. Highland PNG populations also have more mtDNA variability and more mtDNA types represented per founding lineage than coastal PNG populations. All of these observations are consistent with a more ancient, restricted origin of highland PNG populations, internal isolation of highland PNG populations from one another and from coastal populations, and more recent and extensive population movements through coastal PNG. An apparent linguistic effect on PNG mtDNA variation disappeared when geography was taken into account. The high resolution technique for examining mtDNA variation, coupled with extensive geographic sampling within a single defined area, leads to an enhanced understanding of the influence of geography on mtDNA variation in human populations.

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