scholarly journals fMRI for language: how can it replace the Wada test?

2015 ◽  
Vol 42 (S1) ◽  
pp. S27-S27
Author(s):  
S Mousavi ◽  
A Massot Tarrus ◽  
F Bihari ◽  
S Hayman Abello ◽  
B Hayman Abello ◽  
...  
Keyword(s):  
Gold Standard ◽  
Sentence Completion ◽  
Wada Test ◽  
Language Dominance ◽  
Non Invasive ◽  
Language Area ◽  
Left And Right ◽  
The Right ◽  
Verb Generation ◽  
Hemispheric Language Dominance

Background: The goal of our project is to assess the feasibility of replacing the invasive Wada test considered as the gold standard with non-invasive fMRI test for assessment of language dominance preoperatively. Methods: fMRI test with three language paradigm tasks (verb generation, sentence completion and naming) were conducted on our cohort of patients. fMRI laterality indices (LI) were then defined as a ratio (L-R)/(L+R) between the number of activated voxels in the left and right ROIs for Anterior Language Area (ALA) and Posterior Language Area (PLA). fMRI results were divided into the right (LI < -0.2), left (LI > 0.2) or bilateral (-0.2 < LI <0.2) hemispheric language dominance and compared to the results of the Wada test. Results: 28 patients were studied. The concordance rate between Wada and fMRI tests for the ALA and PLA was 68.2% and 52.2% for sentence completion; 56% and 52% for verb generation and 25% and 35% for naming paradigm, respectively. Conclusions: Sentence completion and verb generation fMRI paradigms showed higher concordance with Wada test than naming paradigm. The higher discordance between the Wada test and fMRI was related to bilateral results suggestive of less stringent thresholds used for either test.

scholarly journals Concordance rate between Wada and fMRI tests for visual memory assessment of patients with medically intractable temporal lobe epilepsy

2015 ◽  
Vol 42 (S1) ◽  
pp. S10-S10
Author(s):  
S Mousavi ◽  
A Massot Tarrus ◽  
F Bihari ◽  
S Hayman Abello ◽  
B Hayman Abello ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Visual Memory ◽  
Concordance Rate ◽  
Wada Test ◽  
Memory Assessment ◽  
Non Invasive ◽  
Left And Right ◽  
The Right ◽  
Future Work

Background: There is not enough evidence to prove either invasive Wada or non-invasive fMRI test predicts postoperative memory changes more accurately in patients with refractory temporal lobe epilepsy (TLE). In this study, concordance between fMRI and Wada test for postoperative assessment of visual memory is investigated. Methods: fMRI test with a novel scene-encoding task were conducted on our cohort of patients. fMRI laterality indices (LI) were then defined as a ratio (L-R)/(L+R) between the number of activated voxels in the left and right of two regions: hippocampus+parahippocampus (Region A) and temporal lobe - (hippocampus+parahippocampus) (Region B). fMRI results were divided into the right (LI < -0.2), left (LI > 0.2) or bilateral (-0.2 < LI <0.2) hemispheric memory dominance and compared to the results of the Wada test. Results: 19 patients were studied (14 left TLE, 3 right TLE and 2 bilateral TLE). The concordance rate between Wada and fMRI tests was 36.8% and 42.1% for regions A and B. Conclusions: Based on the results, the concordance rate between the Wada test and the fMRI test is not high. As a future work, we will investigate the correlation of each test to postoperative memory outcome.

scholarly journals Impact of adenosine on mechanisms sustaining persistent atrial fibrillation: Analysis of contact electrograms and non-invasive ECGI mapping data

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248951
Author(s):  
Gurpreet Singh Dhillon ◽  
Nikhil Ahluwalia ◽  
Shohreh Honarbakhsh ◽  
Adam Graham ◽  
Antonio Creta ◽  
...  
Keyword(s):  
Left Atrium ◽  
Persistent Atrial Fibrillation ◽  
Right Atrial ◽  
Mapping Data ◽  
Refractory Periods ◽  
Non Invasive ◽  
Significant Difference ◽  
Left And Right ◽  
The Right ◽  
Number Of Segments

Background We evaluated the effect of adenosine upon mechanisms sustaining persistent AF through analysis of contact electrograms and ECGI mapping. Methods Persistent AF patients undergoing catheter ablation were included. ECGI maps and cycle length (CL) measurements were recorded in the left and right atrial appendages and repeated following boluses of 18 mg of intravenous adenosine. Potential drivers (PDs) were defined as focal or rotational activations completing ≥ 1.5 revolutions. Distribution of PDs was assessed using an 18 segment biatrial model. Results 46 patients were enrolled. Mean age was 63.4 ± 9.8 years with 33 (72%) being male. There was no significant difference in the number of PDs recorded at baseline compared to adenosine (42.1 ± 15.2 vs 40.4 ± 13.0; p = 0.417), nor in the number of segments harbouring PDs, (13 (11–14) vs 12 (10–14); p = 0.169). There was a significantly higher percentage of PDs that were focal in the adenosine maps (36.2 ± 15.2 vs 32.2 ± 14.4; p < 0.001). There was a significant shortening of CL in the adenosine maps compared to baseline which was more marked in the right atrium than left atrium (176.7 ± 34.7 vs 149.9 ± 27.7 ms; p < 0.001 and 165.6 ± 31.7 vs 148.3 ± 28.4 ms; p = 0.003). Conclusion Adenosine led to a small but significant shortening of CL which was more marked in the right than left atrium and may relate to shortening of refractory periods rather than an increase in driver burden or distribution. Registered on Clinicaltrials.gov: NCT03394404.

scholarly journals Serum pepsinogen level and abomasal ulcerations in experimental abomasal displacement in sheep

2010 ◽  
Vol 55 (No. 7) ◽  
pp. 311-317 ◽  
Author(s):  
A. Hajimohammadi ◽  
K. Badiei ◽  
K. Mostaghni ◽  
M. Pourjafar
Keyword(s):  
Mucous Membrane ◽  
Surgical Stress ◽  
Serum Pepsinogen ◽  
Blood Samples ◽  
Non Invasive ◽  
Mucosal Change ◽  
Left And Right ◽  
The Right ◽  
Invasive Techniques ◽  
Abomasal Displacement

It is believed that serum pepsinogen levels could be useful for diagnosis of abomasal changes in cattle. Diagnosis of abomasal displacement (AD) is made via invasive and non-invasive techniques. None of the extant methods is a reliable indication of mucosal change. The applicability of serum pepsinogen levels for the diagnosis of changes in the mucous membrane of the abomasum in experimentally induced left and right AD in sheep was investigated in fourteen rams. Abomasal fluid samples were taken and the pH was recorded. Twelve sheep underwent induced left and right AD (six for each group). Two sheep underwent exploratory laparatomy alone to assess the effect of surgical stress on the abomasum. Blood samples were taken before surgery, at the 1<sup>st</sup>, 3<sup>rd</sup>, 5<sup>th</sup>, 7<sup>th</sup>, 9<sup>th</sup> and 11<sup>th</sup> days after surgery and at the time of necropsy and serum pepsinogen levels were measured. After two weeks the animals were slaughtered and abomasal fluid pH and types of abomasal ulcers were recorded. Significant changes in pepsinogen levels in the left displaced abomasums (LDA) group were seen on days 11 and 14 after surgery (P &lt; 0.05). Significant changes in pepsinogen levels in the right displaced abomasum (RDA) group were seen on Days 9, 11 and 14 after surgery (P &lt; 0.05). There was no association among the types of ulcers and the serum pepsinogen levels in AD cases. The pH increased significantly (P &lt; 0.05) after induced AD in both groups. There were no significant changes in serum pepsinogen levels on different days after surgery among ulcerated and non ulcerated cases in both LDA and RDA groups (P &lt; 0.05). Serum pepsinogen levels were significantly higher in AD groups. There was no association between the types of ulcers and serum pepsinogen levels in AD cases. It seems that the increase in concentration of serum pepsinogen is a good reflection of the damage to the abomasal mucousa due to AD, as was shown by the earlier increase in levels in the course of displacement in the RDA group.

Is Functional MR Imaging Assessment of Hemispheric Language Dominance as Good as the Wada Test?: A Meta-Analysis

Radiology ◽  
2011 ◽  
Vol 261 (2) ◽  
pp. 446-455 ◽  
Author(s):  
R. Joshua Dym ◽  
Judah Burns ◽  
Katherine Freeman ◽  
Michael L. Lipton
Keyword(s):  
Mr Imaging ◽  
Meta Analysis ◽  
Wada Test ◽  
Language Dominance ◽  
Functional Mr Imaging ◽  
Hemispheric Language Dominance

scholarly journals Non-invasive assessment of hemispheric language dominance by optical topography during a brief passive listening test: A pilot study

2011 ◽  
Vol 17 (12) ◽  
pp. CR692-CR697 ◽  
Author(s):  
Stefano Bembich ◽  
Sergio Demarini ◽  
Andrea Clarici ◽  
Stefano Massaccesi ◽  
Domenico Loenardo Grasso
Keyword(s):  
Pilot Study ◽  
Listening Test ◽  
Language Dominance ◽  
Non Invasive ◽  
Passive Listening ◽  
Optical Topography ◽  
Hemispheric Language Dominance

scholarly journals Multimodality language mapping in patients with left-hemispheric language dominance on Wada test

2012 ◽  
Vol 123 (10) ◽  
pp. 1917-1924 ◽  
Author(s):  
Katsuaki Kojima ◽  
Erik C. Brown ◽  
Robert Rothermel ◽  
Alanna Carlson ◽  
Naoyuki Matsuzaki ◽  
...  
Keyword(s):  
Wada Test ◽  
Language Mapping ◽  
Language Dominance ◽  
Hemispheric Language Dominance

3Tesla fMRI study of language dominance in children with epilepsy : is Wada test always the gold standard ?

NeuroImage ◽  
1998 ◽  
Vol 7 (4) ◽  
pp. S459 ◽  
Author(s):  
L Hertz-Pannier ◽  
C Chiron ◽  
PF van de Moortele ◽  
O Dulac ◽  
F Brunelle ◽  
...  
Keyword(s):  
Gold Standard ◽  
Wada Test ◽  
Language Dominance ◽  
Fmri Study

The use of a laser scanning digitiser to assess the accuracy of immobilisation masks

2006 ◽  
Vol 5 (4) ◽  
pp. 191-196
Author(s):  
I. R. Cowley ◽  
S. J. Thomas
Keyword(s):  
Laser Scanning ◽  
Good Accuracy ◽  
Fiducial Marker ◽  
Non Invasive ◽  
System A ◽  
Accuracy And Precision ◽  
Maximum Range ◽  
Left And Right ◽  
The Right ◽  
Head And Neck Radiotherapy

The accuracy of a range of immobilisation systems for head and neck radiotherapy has been measured. Two types of vacuum-formed shells, and eight thermoplastic systems have been evaluated. For each system, a mask was made for the same volunteer. A non-invasive optical system, using a scanning laser digitiser, was used to measure the displacement of a fiducial marker. The volunteer was asked to move a maximum comfortable distance in each of the superior, inferior, left and right directions, and a scan was taken at each location. Standard deviations, calculated from the maximum range of movements, were in the range of 1.7–2.9mm in the right–left direction, and 0.9–3.0mm in the superior–inferior direction. The smallest movements were measured for the Medtec S-frame, with nine-point fixation. A laser-scanning camera can assess the movement potential for a subject inside an immobilisation device with good accuracy and precision. Because ionising radiation is not used as part of the imaging process, the same subject can be used for several mask systems to assess which is the best one.

EXPRESSIVE AND RECEPTIVE LANGUAGE AREAS DETERMINED BY A NON-INVASIVE RELIABLE METHOD USING FUNCTIONAL MAGNETIC RESONANCE IMAGING AND MAGNETOENCEPHALOGRAPHY

Neurosurgery ◽  
2007 ◽  
Vol 60 (2) ◽  
pp. 296-306 ◽  
Author(s):  
Kyousuke Kamada ◽  
Yutaka Sawamura ◽  
Fumiya Takeuchi ◽  
Shinya Kuriki ◽  
Kensuke Kawai ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Receptive Language ◽  
Brain Lesions ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Combined Method ◽  
Wada Test ◽  
Language Dominance ◽  
Non Invasive ◽  
Language Areas

Abstract OBJECTIVE It is known that functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) are sensitive to the frontal and temporal language function, respectively. Therefore, we established combined use of fMRI and MEG to make reliable identification of the global language dominance in pathological brain conditions. METHODS We investigated 117 patients with brain lesions whose language dominance was successfully confirmed by the Wada test. All patients were asked to generate verbs related to acoustically presented nouns (verb generation) for fMRI and to read three-letter words for fMRI and MEG. RESULTS fMRI typically showed prominent activations in the inferior and middle frontal gyri, whereas calculated dipoles on MEG typically clustered in the superior temporal region and the fusiform gyrus of the dominant hemisphere. A total of 87 patients were further analyzed using useful data from both the combined method and the Wada test. Remarkably, we observed a 100% match of the combined method results with the results of the Wada test, including two patients who showed expressive and receptive language areas dissociated into bilateral hemispheres. CONCLUSION The results demonstrate that this non-invasive and repeatable method is not only highly reliable in determining language dominance, but can also locate the expressive and receptive language areas separately. The method may be a potent alternative to invasive procedures of the Wada test and useful in treating patients with brain lesions.

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