scholarly journals P.054 Electroconvulsive therapy and epilepsy: a case report

2019 ◽  
Vol 46 (s1) ◽  
pp. S28
Author(s):  
J Kassiri ◽  
R Ogilvie ◽  
C Elliott ◽  
DB Sinclair
Keyword(s):  
Risk Factors ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Electroconvulsive Therapy ◽  
Electrical Current ◽  
Prior History ◽  
Pediatric Epilepsy ◽  
Refractory Depression ◽  
Clinical Events ◽  
Impaired Awareness

Background: Electroconvulsive therapy (ECT) involves the induction of a generalized seizure with an electrical current and has been used worldwide when treating medically refractory psychiatric illness. Here we describe a patient with no prior history or risk factors for epilepsy who developed temporal lobe epilepsy after chronic treatment of ECT. Methods: A 16-year-old right-handed boy with severe refractory depression received ECT treatment every 10 days for 8 months. Six months into his ECT treatment, the patient developed seizures and was admitted to a pediatric epilepsy monitoring unit. Results: Initial clinical events included lightheadedness, diaphoresis, and nausea with associated kaleidoscopic vision changes. Seizures progressed to confusion, fear and paranoia by the time the patient was admitted for monitoring. Long-term video EEG captured many focal seizures with impaired awareness, all originating from both temporal lobes. MRI was normal. ECT was terminated and the patient started on carbamazepine. He has been seizure free for the past 2 years on medication Conclusions: While rare, we present a case of a patient with no prior risk factors for epilepsy who developed temporal lobe epilepsy after chronic ECT treatment. Although ECT is an indispensable treatment for many medically refractory psychiatric illnesses, we suggest caution in young patient undergoing ECT.

scholarly journals P.015 Mesial Temporal Sclerosis is a rare occurrence in Intractable Pediatric Temporal Lobe Epilepsies

2018 ◽  
Vol 45 (s2) ◽  
pp. S19-S19
Author(s):  
J Kassiri ◽  
T Rajapakse ◽  
L Schmitt ◽  
M Wheatley ◽  
B Sinclair
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Pediatric Patients ◽  
Focal Cortical Dysplasia ◽  
Surgical Pathology ◽  
Pediatric Epilepsy ◽  
Mesial Temporal Sclerosis ◽  
Surgical Interventions ◽  
Retrospective Cohort Studies ◽  
Magnetic Resonance Imaging Mri

Background: Temporal lobe epilepsy (TLE) accounts for approximately 20% of pediatric epilepsy cases. Of those, many are considered medically intractable and require surgical interventions. In this study, we hypothesized that mesial temporal sclerosis (MTS) was less common in patients who had undergone surgery for intractable pediatric TLE than in adult series. We further hypothesized that there was a radiological and pathological discordance in identifying the cause of pediatric TLE. Methods: We retrospectively reviewed the charts of pediatric patients with TLE who had undergone surgical treatments as part of the University of Alberta’s Comprehensive Epilepsy Program between 1988 and 2018. Along with preoperative magnetic resonance imaging (MRI) reports, post-surgical pathology results and seizure outcomes were studied Results: Of the 83 pediatric patients who had undergone temporal lobe epilepsy surgery, 28% had tumors, 22% had dual pathologies, 18% had MTS, 11% had focal cortical dysplasia, and 22% had other pathologies. In addition, for 36% of these patients, discordance between their pre-surgical MRI reports and post-surgical pathology reports were found. Conclusions: This was one of the largest retrospective cohort studies of pediatric patients who had undergone surgery for intractable TLE. This study showed that tumors, and not MTS, were the most common pathology in surgical pediatric TLE.

Risk factors for spatial memory impairment in patients with temporal lobe epilepsy

2013 ◽  
Vol 26 (1) ◽  
pp. 57-60 ◽  
Author(s):  
Jana Amlerova ◽  
Jan Laczo ◽  
Kamil Vlcek ◽  
Alena Javurkova ◽  
Ross Andel ◽  
...  
Keyword(s):  
Risk Factors ◽  
Temporal Lobe Epilepsy ◽  
Spatial Memory ◽  
Temporal Lobe ◽  
Memory Impairment

scholarly journals The impact of cerebrovascular risk factors on postoperative memory decline in patients with left temporal lobe epilepsy

2020 ◽  
Vol 102 ◽  
pp. 106558
Author(s):  
Anny Reyes ◽  
Sanam J. Lalani ◽  
Erik Kaestner ◽  
Kiera Hooper ◽  
Austin Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Left Temporal Lobe ◽  
Memory Decline ◽  
Cerebrovascular Risk Factors ◽  
Cerebrovascular Risk ◽  
The Impact

scholarly journals Adenosine kinase and adenosine receptors A 1 R and A 2A R in temporal lobe epilepsy and hippocampal sclerosis and association with risk factors for SUDEP

Epilepsia ◽  
2020 ◽  
Vol 61 (4) ◽  
pp. 787-797
Author(s):  
Smriti Patodia ◽  
Beatrice Paradiso ◽  
Maria Garcia ◽  
Matthew Ellis ◽  
Beate Diehl ◽  
...  
Keyword(s):  
Risk Factors ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Adenosine Receptors ◽  
Hippocampal Sclerosis ◽  
Adenosine Kinase

Spikes Immediately after Electroconvulsive Therapy in Psychotic Patients

2003 ◽  
Vol 34 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Fumio Kubota ◽  
Nobuyoshi Shibata ◽  
Takushiro Akata ◽  
Senichiro Kikuchi ◽  
Akira Kifune ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Electroconvulsive Therapy ◽  
Early Stage ◽  
Electrical Current ◽  
Temporal Region ◽  
Repeated Application

The goal of this study was to assess the spikes systematically and to clarify an epileptic abnormality induced by electroconvulsive therapy (ECT). Our subjects were 20 psychotic patients with no spikes on prior EEGs. ECT was performed by applying electrical current to both sides of the patient's temple every 2 or 3 days for a period of between 1–4 weeks. The first EEG examination was performed either on the day that the ECT course was completed or on the following day. Subsequent EEG examinations were performed at intervals of 2 or 3 days. Thirteen of the 20 patients showed spikes. There were no significant differences in age, gender, diagnosis, or type of ECT. Patients with spikes had significantly more ECT sessions than those without spikes. The spikes were present in the frontal, temporal and central areas, predominantly frontal, anterior temporal and mid-temporal region, and almost disappeared in 1–3 weeks. The occurrence of spikes immediately after ECT was demonstrated. Although this abnormality was transient, it could indicate that in humans ECT causes the early stage of kindling phenomenon as a result of repeated application, and that the temporal lobe seems to play a major role in order to induce the phenomenon.

scholarly journals Temporal lobe epilepsy following maintenance electroconvulsive therapy-Electrical kindling in the human brain?

Epilepsia ◽  
2016 ◽  
Vol 57 (11) ◽  
pp. e216-e220 ◽  
Author(s):  
Alexander Bryson ◽  
Helen Gardner ◽  
Ian Wilson ◽  
Tim Rolfe ◽  
John Archer
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Human Brain ◽  
Temporal Lobe ◽  
Electroconvulsive Therapy ◽  
Electrical Kindling

scholarly journals Diagnosing Cognitive Disorders in Older Adults with Temporal Lobe Epilepsy

2020 ◽  
Author(s):  
Anny Reyes ◽  
Erik Kaestner ◽  
Emily C Edmonds ◽  
Anna Christina Macari ◽  
Zhong Irene Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Cognitive Impairment ◽  
Temporal Lobe Epilepsy ◽  
Diagnostic Criteria ◽  
Temporal Lobe ◽  
Cognitive Disorders ◽  
Vascular Risk Factors ◽  
Classification Model ◽  
Vascular Risk

Objective: To characterize the nature and prevalence of cognitive disorders in older adults with temporal lobe epilepsy (TLE) and compare their cognitive profiles to non-epileptic patients with mild cognitive impairment (i.e., classic MCI; cMCI). Methods: Seventy-eight older patients with TLE, 77 cMCI, and 69 normal aging controls (NAC), all 55-80 years, completed neuropsychological measures of memory, language, executive function and processing speed. An actuarial neuropsychological method designed to diagnose MCI was applied to individual patients to identify older adults with TLE who met diagnostic criteria for MCI (TLE-MCI). A linear classifier was performed to evaluate how well the diagnostic criteria differentiated patients with TLE-MCI from cMCI. In TLE, the contribution of epilepsy-related and vascular risk factors to cognitive impairment was evaluated using multiple regression. Results: Forty-three TLE patients (60%) met criteria for TLE-MCI, demonstrating marked deficits in both memory and language. A classification model between TLE-MCI and cMCI correctly classified 81.1% (90.6% specificity, 61.3% sensitivity) of the cohort based on neuropsychological scores. Whereas TLE-MCI showed greater deficits in language relative to cMCI, patients with cMCI showed greater rapid forgetting on memory measures. Both epilepsy-related risk factors and the presence of leukoaraiosis on MRI contributed to impairment profiles in TLE-MCI. Interpretation: Approximately 60% of older adults with TLE meet diagnostic criteria for a cognitive disorder associated with aging (i.e., MCI). The TLE-MCI phenotype may be secondary to an accumulation of epilepsy and vascular risk factors, signal the onset of a neurodegenerative disease, or represent a combination of both factors.

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