scholarly journals Nutritional components can influence hair coat colouration in white dogs

2017 ◽  
Vol 5 ◽  
Author(s):  
Adrian Watson ◽  
Laurence Le Verger ◽  
Anne-Laure Guiot ◽  
Alexander Feugier ◽  
Vincent Biourge
Keyword(s):  
Phenotypic Expression ◽  
Hair Shaft ◽  
White Coat ◽  
Test Diet ◽  
Space System ◽  
Hair Coat ◽  
Cie Lab ◽  
The Impact ◽  
Hair Cortex

SummaryHair colouration in animals is controlled primarily by inherited factors, with a complex set of genes and genetic variants determining phenotypic expression. The colours in the hair shaft are created initially by the melanocyte cells within the hair bulb which produce and secrete two types of melanin into the hair cortex, black eumelanin and brown pheomelanin. Together these two pigments are responsible for creating the considerable diversity of colour seen in hair across the animal kingdom. In the absence of melanins the hair remains translucent, appearing white to the eye. Colour, or absence thereof, can only be imparted on a hair during its ‘anagen’ or growing phase. During the telogen (resting) phase the colour of the hair is relatively constant, notwithstanding effects of environmental influences such as UV in sunlight, or staining agents. A further environmental factor is nutrition. The intensity of black in the hair of both cats and dogs is known to be influenced by the dietary intake of certain amino acids such as phenylalanine (Phe) and tyrosine (Tyr). However the role of nutrition in hair pigmentation is generally poorly understood. This trial investigated the impact of diet on the commonly observed red discolouration of white coat in dogs. Two panels of 13 Swiss White Shepherd dogs were fed diets containing different concentrations of Phe + Tyr (test diet containing 3.02 g/Mcal versus control 4.82 g/Mcal) and copper (test diet containing 8.93 ppm versus control 13.28 ppm) for four months. Coat colouration was assessed via spectrophotometry using the CIE Lab colour space system (International Commission on Illumination). Dogs fed the reduced Phe + Tyr and copper showed significantly less red coat pigmentation (a* parameter) by the end of the feeding study (P < 0.02). It was concluded that the level of Phe + Tyr not only affects black but also white coat in dogs. Diet can therefore exert an influence on multiple aspects of coat pigmentation.

Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers

Development ◽  
2000 ◽  
Vol 127 (11) ◽  
pp. 2421-2432 ◽  
Author(s):  
M.H. Lin ◽  
C. Leimeister ◽  
M. Gessler ◽  
R. Kopan
Keyword(s):  
Transgenic Mice ◽  
Hair Follicle ◽  
Active Form ◽  
Notch Pathway ◽  
Dermal Papilla ◽  
Cell Types ◽  
Hair Shaft ◽  
Hair Follicles ◽  
Hair Cortex

Little is known about the mechanisms underlying the generation of various cell types in the hair follicle. To investigate the role of the Notch pathway in this process, transgenic mice were generated in which an active form of Notch1 (Notch(DeltaE)) was overexpressed under the control of the mouse hair keratin A1 (MHKA1) promoter. MHKA-Notch(DeltaE) is expressed only in one precursor cell type of the hair follicle, the cortex. Transgenic mice could be easily identified by the phenotypes of curly whiskers and wavy, sheen pelage hair. No effects of activated Notch on proliferation were detected in hair follicles of the transgenic mice. We find that activating Notch signaling in the cortex caused abnormal differentiation of the medulla and the cuticle, two neighboring cell types that did not express activated Notch. We demonstrate that these non-autonomous effects are likely caused by cell-cell interactions between keratinocytes within the hair follicle and that Notch may function in such interactions either by directing the differentiation of follicular cells or assisting cells in interpreting a gradient emanating from the dermal papilla.

Intergroup Threat and Outgroup Attitudes

2013 ◽  
Vol 44 (5) ◽  
pp. 311-319 ◽  
Author(s):  
Marco Brambilla ◽  
David A. Butz
Keyword(s):  
Gay Men ◽  
Social Group ◽  
Welfare Recipients ◽  
Intergroup Attitudes ◽  
Social Policies ◽  
Intergroup Threat ◽  
Economic Threat ◽  
The Impact ◽  
General Climate

Two studies examined the impact of macrolevel symbolic threat on intergroup attitudes. In Study 1 (N = 71), participants exposed to a macrosymbolic threat (vs. nonsymbolic threat and neutral topic) reported less support toward social policies concerning gay men, an outgroup whose stereotypes implies a threat to values, but not toward welfare recipients, a social group whose stereotypes do not imply a threat to values. Study 2 (N = 78) showed that, whereas macrolevel symbolic threat led to less favorable attitudes toward gay men, macroeconomic threat led to less favorable attitudes toward Asians, an outgroup whose stereotypes imply an economic threat. These findings are discussed in terms of their implications for understanding the role of a general climate of threat in shaping intergroup attitudes.

The Impact of Parental Autonomy Support on Career Adaptability: The Mediating Role of Perfectionism

2015 ◽  
Author(s):  
Danni Wang ◽  
Zhi-Jin Hou ◽  
Haoyang Chi ◽  
Yin Jia
Keyword(s):  
Autonomy Support ◽  
Career Adaptability ◽  
Mediating Role ◽  
Parental Autonomy Support ◽  
Parental Autonomy ◽  
The Impact

The impact of HIV-status disclosure on quality of life and the mediational role of avoidance coping

2013 ◽  
Author(s):  
Calvin Fitch ◽  
Gail Ironson ◽  
Neil Schneiderman
Keyword(s):  
Quality Of Life ◽  
Hiv Status ◽  
Avoidance Coping ◽  
Hiv Status Disclosure ◽  
Mediational Role ◽  
Status Disclosure ◽  
The Impact

Rapid evaluation of FDG imaging alternatives using head-to-head comparisons of full ring and gamma camera based PET scanners –

2002 ◽  
Vol 41 (05) ◽  
pp. 208-213 ◽  
Author(s):  
L. M. Haslinghuis-Bajan ◽  
L. Hooft ◽  
A. van Lingen ◽  
M. van Tulder ◽  
W. Devillé ◽  
...  
Keyword(s):  
Methodological Quality ◽  
Gamma Camera ◽  
First Generation ◽  
Prospective Evaluation ◽  
First Approximation ◽  
Variable Head ◽  
Malignant Lesions ◽  
The Impact ◽  
Pet Scanners

SummaryAim: While FDG full ring PET (FRPET) has been gradually accepted in oncology, the role of the cheaper gamma camera based alternatives (GCPET) is less clear. Since technology is evolving rapidly, “tracker trials” would be most helpful to provide a first approximation of the relative merits of these alternatives. As difference in scanner sensitivity is the key variable, head-to-head comparison with FRPET is an attractive study design. This systematic review summarises such studies. Methods: Nine studies were identified until July 1, 2000. Two observers assessed the methodological quality (Cochrane criteria), and extracted data. Results: The studies comprised a variety of tumours and indications. The reported GC- and FRPET agreement for detection of malignant lesions ranged from 55 to 100%, but with methodological limitations (blinding, standardisation, limited patient spectrum). Mean lesion diameter was 2.9 cm (SD 1.8), with only about 20% <1.5 cm. The 3 studies with the highest quality reported concordances of 74-79%, for the studied lesion spectrum. Contrast at GCPET was lower than that of FRPET, contrast and detection agreement were positively related. Logistic regression analysis suggested that pre-test indicators might be used to predict FRPET-GCPET concordance. Conclusion: In spite of methodological limitations, “first generation” GCPET devices detected sufficient FRPET positive lesions to allow prospective evaluation in clinical situations where the impact of FRPET is not confined to detection of small lesions (<1.5 cm). The efficiency of head-to-head comparative studies would benefit from application in a clinically relevant patient spectrum, with proper blinding and standardisation of acquisition procedures.

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