scholarly journals The Nordic diet and cognition – The DR's EXTRA Study

2015 ◽  
Vol 114 (2) ◽  
pp. 231-239 ◽  
Author(s):  
Reija Männikkö ◽  
Pirjo Komulainen ◽  
Ursula Schwab ◽  
Harri M. Heikkilä ◽  
Kai Savonen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Positive Association ◽  
Word List ◽  
Population Based ◽  
Lifestyle Factor ◽  
Related Factors ◽  
Cross Sectional ◽  
Nordic Diet ◽  
Diet Score

The rapid increase in the prevalence of dementia associated with ageing populations has stimulated interest in identifying modifiable lifestyle factors that could prevent cognitive impairment. One such potential preventive lifestyle factor is the Nordic diet that has been shown to reduce the risk of CVD; however, its effect on cognition has not been studied. The aim of the present study was to estimate the cross-sectional and longitudinal associations of the baseline Nordic diet with cognitive function at baseline and after a 4-year follow-up in a population-based random sample (n1140 women and men, age 57–78 years) as secondary analyses of the Finnish Dose-Responses to Exercise Training study. The Nordic diet score was created based on reported dietary components in 4-d food records. Cognition was assessed by the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery and the Mini-mental State Examination (MMSE). The baseline Nordic diet score had been positively associated with Verbal Fluency (β 0·08 (95 % CI 0·00, 0·16),P= 0·039) and Word List Learning (β 0·06 (95 % CI 0·01, 0·10),P= 0·022) at 4 years but not with the Consortium to Establish a Registry for Alzheimer's Disease total score (CERAD-TS) or MMSE at 4 years, after adjustment for baseline cognitive scores, demographic factors and health-related factors. After excluding individuals with impaired cognition at baseline, the baseline Nordic diet score had also been positively associated with the CERAD-TS (β 0·10 (95 % CI 0·00, 0·20),P= 0·042) and MMSE (β 0·03 (95 % CI 0·00, 0·06),P= 0·039) at 4 years. These associations disappeared after further adjustment for energy intake. In conclusion, the Nordic diet might have a positive association with cognition in individuals with normal cognition.

scholarly journals Prevalence and correlates of Alzheimer’s disease and related dementias in rural Uganda: cross-sectional, population-based study

2019 ◽  
Author(s):  
VINCENT MUBANGIZI ◽  
Samuel Maling ◽  
Celestino Obua ◽  
Alexander C. Tsai
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Population Based ◽  
Cross Sectional ◽  
Population Based Study ◽  
Community Screening ◽  
Multi Stage ◽  
Multivariable Regression ◽  
Sub Saharan ◽  
Southwestern Uganda

Abstract Introduction There is a paucity of data on the prevalence and correlates of Alzheimer’s disease and related dementias in sub-Saharan Africa.Objective To estimate the prevalence and correlates of Alzheimer’s disease and related dementias in rural Uganda.Methods We conducted a cross-sectional, population-based study in a rural region of southwestern Uganda. The Brief Community Screening Instrument for Dementia was administered to a multi-stage area probability sample of 400 people aged 60 years and over. Multivariable logistic regression was used to estimate correlates of probable dementia.Results Overall, 80 (20%) of the sample screened positive for dementia. On multivariable regression, we estimated the following correlates of probable dementia: age (adjusted odds ratio [AOR], 1.02 per year; 95% confidence interval [CI], 1.10-1.03, p˂0.001), having some education (AOR, 0.57; 95% CI, 0.41-0.81, p=0.001), exercise (AOR, 0.44; 95% CI, 0.27-0.72, p=0.001), and having a ventilated kitchen (AOR, 0.43; (95% CI, 0.24-0.77, p=0.001).Conclusion In this population-based sample of older-age adults, nearly one-fifth screened positive for dementia.

scholarly journals Association of Accelerated Long-term Forgetting and Senescence-related Blood-borne Factors in Asymptomatic Individuals From Families With Autosomal Dominant Alzheimer’s Disease

2021 ◽  
Author(s):  
Jianwei Yang ◽  
Chaojun Kong ◽  
Longfei Jia ◽  
Tingting Li ◽  
Meina Quan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Autosomal Dominant ◽  
Word List ◽  
Related Factors ◽  
Blood Concentrations ◽  
Mutation Carriers ◽  
Asymptomatic Individuals ◽  
Three Delays

Abstract Background: Accelerated long-term forgetting has been identified in preclinical Alzheimer’s disease (AD), and is attributed to a selective impairment of memory consolidation in which hippocampus plays a key role. As blood may contain multiple senescence-related factors that involved in neurogenesis and synaptic plasticity in the hippocampus, we tested whether there is an association between blood-borne factors and accelerated long-term forgetting in asymptomatic individuals from families with autosomal dominant AD (ADAD). Methods: We analyzed data of 39 asymptomatic participants (n=18 ADAD mutation carriers, n=21 non-carriers) from the Chinese Familial Alzheimer’s Disease Network (CFAN) study. Long-term forgetting rates were calculated based on recall or recognition of two materials (word list and complex figure) at three delays comprising immediate, 30 min and 7 days. Peripheral blood concentrations of candidate pro-aging factors (C-C motif ligand 11 [CCL11] and monocyte chemotactic protein 1 [MCP1]) and rejuvenation factors (growth differentiation factor 11 [GDF11], thrombospondin-4 [THBS4], and secreted protein acidic and rich in cysteine like 1 [SPARCL1]) were evaluated in all participants. Results: Despite normal performance on standard 30-min delayed testing, mutation carriers exhibited accelerated forgetting of verbal and visual material over 7 days in comparison with matched non-carriers. In the whole sample, lower plasma THBS4 was associated with accelerated long-term forgetting in list recall (β= -0.46, p=0.002), figure recall (β= -0.44, p=0.004) and list recognition (β= -0.37, p=0.010). Additionally, higher plasma GDF11 and CCL11 were both associated with accelerated long-term forgetting (GDF11 versus figure recall: β=0.39, p=0.007; CCL11 versus list recognition: β=0.44, p=0.002).Conclusions: Accelerated long-term forgetting is a cognitive feature of presymptomatic AD. Senescence-related blood-borne factors, especially THBS4, GDF11, and CCL11, may be promising biomarkers for the prediction of accelerated long-term forgetting.

scholarly journals Prevalence and correlates of Alzheimer’s disease and related dementias in rural Uganda: cross-sectional, population-based study

2020 ◽  
Author(s):  
VINCENT MUBANGIZI ◽  
Samuel Maling ◽  
Celestino Obua ◽  
Alexander C. Tsai
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Population Based ◽  
Cross Sectional ◽  
Population Based Study ◽  
Community Screening ◽  
Multi Stage ◽  
Multivariable Regression ◽  
Sub Saharan ◽  
Southwestern Uganda

Abstract Introduction There is a paucity of data on the prevalence and correlates of Alzheimer’s disease and related dementias in sub-Saharan Africa.Objective To estimate the prevalence and correlates of Alzheimer’s disease and related dementias in rural Uganda.Methods We conducted a cross-sectional, population-based study in a rural region of southwestern Uganda. The Brief Community Screening Instrument for Dementia was administered to a multi-stage area probability sample of 400 people aged 60 years and over. Multivariable logistic regression was used to estimate correlates of probable dementia.Results Overall, 80 (20%) of the sample screened positive for dementia. On multivariable regression, we estimated the following correlates of probable dementia: age (adjusted odds ratio [AOR], 1.02 per year; 95% confidence interval [CI], 1.10-1.03, p˂0.001), having some education (AOR, 0.57; 95% CI, 0.41-0.81, p=0.001), exercise (AOR, 0.44; 95% CI, 0.27-0.72, p=0.001), and having a ventilated kitchen (AOR, 0.43; (95% CI, 0.24-0.77, p=0.001).Conclusion In this population-based sample of older-age adults, nearly one-fifth screened positive for dementia.

scholarly journals Knowledge, attitudes, and practice towards COVID-19 among multi-ethnic elderly Asian residents in Singapore: a mixed methods study

2021 ◽  
Author(s):  
A Aravindhan ◽  
ATL Gan ◽  
EPX Lee ◽  
P Gupta ◽  
R Man ◽  
...  
Keyword(s):  
Mixed Methods ◽  
Preventive Measures ◽  
Healthy Lifestyle ◽  
Qualitative Interviews ◽  
Positive Association ◽  
Population Based ◽  
Mixed Methods Study ◽  
Related Factors ◽  
Cross Sectional ◽  
Attitudes And Practices

Introduction: We investigated knowledge, attitudes, and practice (KAP) about COVID-19 and related preventive measures in Singaporeans aged > 60 years. Methods: This was a population-based, cross-sectional, mixed-methods study (13 May 2020–9 June 2020) of participants aged >60 years. Self-reported KAP about ten COVID-19 symptoms and six government-endorsed preventive measures were evaluated. Multivariable regression models identified sociodemographic and health-related factors associated with knowledge, attitudes and practices in our sample. Associations between knowledge/attitude scores, and practice categories were determined using logistic regression. 78 participants were interviewed qualitatively about practice of additional preventive measures and data were analysed thematically. Results: Mean awareness score of the symptoms was 7.2/10. Fever (93.0%) and diarrhoea (33.5%) were the most- and least-known symptoms, respectively. Most knew all six preventive measures (90.4%), perceived them as effective (78.7%), and practiced ‘wear a mask’ (97.2%). Indians, Malays, and those in smaller housing had poorer mean knowledge of COVID-19 symptoms scores. Older participants had poorer attitudes towards preventive measures. Compared to Chinese, Indians had lower odds of practicing 3/6 recommendations. A one-point increase in knowledge of and attitudes towards preventive measures score had higher odds of always practicing 3/6 and 2/6 measures, respectively. Qualitative interviews revealed use of other preventive measures, e.g. maintaining a healthy lifestyle. Conclusions: Elderly Singaporeans displayed high levels of KAP about COVID-19 and related preventive measures, with a positive association between levels of knowledge/attitude, and practice. However, important ethnic and socioeconomic disparities were evident, suggesting key vulnerabilities remain, requiring immediate attention.

scholarly journals Association of accelerated long-term forgetting and senescence-related blood-borne factors in asymptomatic individuals from families with autosomal dominant Alzheimer’s disease

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Jianwei Yang ◽  
Chaojun Kong ◽  
Longfei Jia ◽  
Tingting Li ◽  
Meina Quan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Autosomal Dominant ◽  
Word List ◽  
Related Factors ◽  
Blood Concentrations ◽  
Mutation Carriers ◽  
Chemokine Ligand ◽  
Asymptomatic Individuals

Abstract Background Accelerated long-term forgetting has been identified in preclinical Alzheimer’s disease (AD) and is attributed to a selective impairment of memory consolidation in which the hippocampus plays a key role. As blood may contain multiple senescence-related factors that involved in neurogenesis and synaptic plasticity in the hippocampus, we tested whether there is an association between blood-borne factors and accelerated long-term forgetting in asymptomatic individuals from families with autosomal dominant AD (ADAD). Methods We analyzed data of 39 asymptomatic participants (n = 18 ADAD mutation carriers, n = 21 non-carriers) from the Chinese Familial Alzheimer’s Disease Network (CFAN) study. Long-term forgetting rates were calculated based on recall or recognition of two materials (word list and complex figure) at three delays comprising immediate, 30 min, and 7 days. Peripheral blood concentrations of candidate pro-aging factors (CC chemokine ligand 11 [CCL11] and monocyte chemotactic protein 1 [MCP1]) and rejuvenation factors (growth differentiation factor 11 [GDF11], thrombospondin-4 [THBS4], and secreted protein acidic and rich in cysteine like 1 [SPARCL1]) were evaluated in all participants. Results Despite normal performance on standard 30-min delayed testing, mutation carriers exhibited accelerated forgetting of verbal and visual material over 7 days in comparison with matched non-carriers. In the whole sample, lower plasma THBS4 was associated with accelerated long-term forgetting in list recall (β = −0.46, p = 0.002), figure recall (β = −0.44, p = 0.004), and list recognition (β = −0.37, p = 0.010). Additionally, higher plasma GDF11 and CCL11 were both associated with accelerated long-term forgetting (GDF11 versus figure recall: β = 0.39, p = 0.007; CCL11 versus list recognition: β = 0.44, p = 0.002). Conclusions Accelerated long-term forgetting is a cognitive feature of presymptomatic AD. Senescence-related blood-borne factors, especially THBS4, GDF11, and CCL11, may be promising biomarkers for the prediction of accelerated long-term forgetting.

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