Interactions of Dietary Insulin Index and Dietary Insulin Load with BDNF Val66Met Polymorphism in Relation to Cardiometabolic Markers in Iranian Diabetic Patients: A Cross-Sectional Study

2021 ◽  
pp. 1-22
Author(s):  
Faezeh Abaj ◽  
Masoumeh Rafiee ◽  
Fariba Koohdani
Keyword(s):  
Metabolic Diseases ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Dietary Intakes ◽  
Sectional Study ◽  
Cross Sectional ◽  
Val66met Polymorphism ◽  
Bdnf Val66met Polymorphism ◽  
Genetic And Environmental Factors ◽  
Cardiometabolic Markers

Abstract The progression of cardiometabolic diseases is determined by both genetic and environmental factors. Gene-diet interactions may therefore be important in modulating the risks of developing metabolic diseases. The objectives were to investigate the effect of the interaction between BDNF Val66Met polymorphisms and Dietary Insulin Index and Insulin Load (DII and DIL) on Cardiometabolic Markers among diabetic patients. In this cross-sectional study, blood samples were collected from 667 patients. DIL & DII were defined using a validated food frequency questionnaire (FFQ). Genotyping the BDNF Val66Met polymorphism was conducted by the PCR-RFLP method. Interactions between dietary indices and gene variants were evaluated using a Generalized Linear Model (GLM). PGF2a concentrations were significantly higher among Val homozygotes than Met alleles carrier. This study revealed that, compared with individuals with the Val/Val genotype, those with the Met/Val or Met/Met genotype had lower BMI (P-interaction =0.04), TG (P-interaction=0.04), leptin (P-interaction =0.01), LDL (P-interaction=0.04) and TC (P-interaction =0.01) when they consumed diets higher on the DIL index. Moreover, the highest quartile of the DIL, compared to the lowest, showed increased in WC (P-interaction =0.02) and LDL/HDL (P-interaction =0.04) for Val/Val homozygotes compared to Met-allele carriers. BDNF Val66Met variants may interact with DIL and DII, thus be involved in the development of cardiometabolic risk factors. If diabetic patients with Met alleles regulate dietary intakes, they have a protective opportunity to regulate their cardiometabolic markers.

scholarly journals Interactions between DRD2/ANKK1 TaqIA Polymorphism and Dietary Factors Influence Plasma Triglyceride Concentrations in Diabetic Patients from Western Mexico: A Cross-sectional Study

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2863 ◽  
Author(s):  
Omar Ramos-Lopez ◽  
Roberto Mejia-Godoy ◽  
Kevin J. Frías-Delgadillo ◽  
Rafael Torres-Valadez ◽  
Aurelio Flores-García ◽  
...  
Keyword(s):  
Dietary Cholesterol ◽  
Blood Lipid ◽  
Cross Sectional Study ◽  
Dietary Factors ◽  
Diabetic Patients ◽  
Dietary Intakes ◽  
Sectional Study ◽  
Cross Sectional ◽  
Western Mexico ◽  
Genotype Frequencies

This study aimed to screen relevant interactions between DRD2/ANKK1 TaqIA polymorphism and dietary intakes with reference to phenotypical features in patients with T2D from western Mexico. In this cross-sectional study, a total of 175 T2D patients were enrolled. Dietary intake was evaluated using 3-day food records and appropriate software. Glycemic and blood lipid profiles were measured by standardized methods. Genotyping of the DRD2/ANKK1 TaqIA polymorphism was performed by the RFLP method. Gene-diet interactions regarding anthropometric and metabolic phenotypes were screened by adjusted multiple linear regression analyses. Genotype frequencies of the DRD2/ANKK1 TaqIA polymorphism were A1A1 (16.0%), A1A2 (52.6%), and A2A2 (31.4%). Statistically significant interactions between the DRD2/ANKK1 TaqIA genotypes and dietary factors in relation to blood triglyceride (TG) levels were found. Carriers of the A1 allele (A1A1 homozygotes plus A1A2 heterozygotes) were protected from TG increases by maltose intake (P int. = 0.023). Instead, A2A2 homozygotes were susceptible to TG rises through consumptions of total fat (P int. = 0.041), monounsaturated fatty acids (P int. = 0.001), and dietary cholesterol (P int. = 0.019). This study suggests that the interactions between DRD2/ANKK1 TaqIA polymorphism and dietary factors (sugar and fats) influence TG levels in diabetic patients.

scholarly journals Association between Hyperhomocysteinemia and Thyroid Hormones in Euthyroid Diabetic Subjects

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Yun Zhang ◽  
Qiong Wang ◽  
Quanzhong Li ◽  
Ping Lu
Keyword(s):  
Blood Pressure ◽  
Fasting Glucose ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
Diabetic Patients ◽  
Biomedical Data ◽  
Sectional Study ◽  
Free Triiodothyronine ◽  
Cross Sectional ◽  
Elderly Males

Objectives. The concept now emerging is that higher thyroid-stimulating hormone (TSH) and lower thyroid hormone levels within the euthyroid range may adversely affect atherosclerosis. The present study aimed to investigate the potential associations between thyroid parameters and hyperhomocysteinaemia in a cohort of euthyroid diabetic subjects.Material and Methods. Two hundred and seventy-three euthyroid diabetic subjects (167 males and 106 females) were consecutively recruited in this cross-sectional study. Clinical and biomedical data was collected.Results. TSH level was higher in females than males. Compared to normal-homocysteine group, hyperhomocysteinaemia group was more likely to be elderly, males, with longer diabetes history, and with lower diastolic blood pressure. Free thyroxine (FT4) level was lower in hyperhomocysteinaemia group than in normal-homocysteine group; however, it was not statistically significant. Adjusted for age, sex, body mass index, duration of diabetes, blood pressure, fasting glucose, total cholesterol, and triglyceride in logistic regression analyses, hyperhomocysteinaemia was significantly correlated with FT4 (P=0.021). No significant association was found with TSH or free triiodothyronine. When analyzed in subjects with TSH < 2.5 uIU/mL separately, we got similar results.Conclusions. In conclusion, we identified a relation between hyperhomocysteinemia and FT4 in a group of euthyroid diabetic patients.

THE PREVALENCE OF HYPERTENSION IN DIABETIC AND NON-DIABETIC STROKE PATIENTS IN COMMUNITY HOSPITAL OF DISTRICT SWAT, PAKISTAN

1969 ◽  
Vol 2 (2) ◽  
pp. 187-191
Author(s):  
Sahibzada Saeed Jan ◽  
Taj Muhammad Khan ◽  
Alamzeb ◽  
Izaz-urrahman ◽  
Amanullah ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Community Hospital ◽  
Macrovascular Disease ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Elevated Blood ◽  
Sectional Study ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Hospital District

Background: As hypertension is the most important risk factor for stroke, it is generally considered to beasymptomatic condition and require lifetime therapy which may include chemotherapy and lifestylechanges. Hypertension also clearly contributes to the risk of macrovascular disease in patients with type-IIdiabetes mellitus. Therefore, the present study was conducted to evaluate the prevalence of hypertension indiabetic and non-diabetic stroke patients in community hospital district Swat. Methodology: This was a cross-sectional study, comprised of 100 subjects, 50 were diabetic and 50 werenon-diabetic stroke patients of ages between 28 to 90 years. The blood sugar (random and fasting), bloodpressure (systolic and diastolic) of Diabetic stroke subjects were compared with Non-diabetic strokesubjects. Results: The prevalence of hypertension was significantly high in diabetic stroke subject as compared tonon-diabetic stroke subjects. Conclusion: Diabetic patients with persistently elevated blood pressure are more prone to develop stroke ascompared to non diabetic with hypertension KEYWORDS:Stroke, Diabetes mellitus, hypertension.

Outcomes of Nonalcoholic Fatty Liver Disease In Covid Positive Diabetic Patients: Cross Sectional Study

2021 ◽  
Vol 15 (12) ◽  
pp. 3241-3243
Author(s):  
Azhar Hussain ◽  
Mehwish Iftikhar ◽  
Amna Rizvi ◽  
Muhammad Latif ◽  
Muhammad Javed Ahmed ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Statistical Significance ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Sectional Study ◽  
Cross Sectional ◽  
Nonalcoholic Fatty Liver

Background: SARS-CoV-2 principally invades the respiratory system. ACE receptor are also abundant throughout the hepatobiliary system and their increased expression on hepatocyte make patients with NAFLD more vulnerable. Aim: To see outcomes of COVID positive diabetic patients suffering from Nonalcoholic fatty liver disease (NAFLD). Study design: Cross Sectional Study. Methodology: 150 diabetic and COVID PCR positive were recruited from COVID ward of Services Hospital in Lahore. Clinical parameters like BMI, SpO2, Hepatomegaly and lab parameters like HbA1C, AST ALT were noted in spreadsheet. Statistical analysis was done using SPSS v.25. Statistical significance for difference in proportions is calculated using Pearson’s Chi-Squared test. P less than 0.05 was considered statistically significant. Results: Around 84(56%) were males and 66(44%) females, smoked were 27(18%), mean age (years) was 59.7333 ±11.35023, mean BMI (kg/m²) was 30.1425±7.30673, 87(58%) patients had NAFLD, who experienced sever disease (53.2%; x^2=0.010) and more mortalities (60.2%;x^2=0.453) as compared to those who do not had condition. Conclusion: We concluded that NAFLD makes COVID-19 infected patients more fragile. Such patients experienced sever disease and more mortalities however need of mechanical ventilation remains almost equal between those who has NAFLD and those who didn’t had. Keywords: Nonalcoholic fatty liver disease, COVID-19, Diabetes, Mortality and Severity.

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