The molecular genetics of inherited deafness – current knowledge and recent advances

1998 ◽  
Vol 112 (5) ◽  
pp. 432-437 ◽  
Author(s):  
Rachel E. Hardisty ◽  
Jane Fleming ◽  
Karen P. Steel
2006 ◽  
Vol 73 ◽  
pp. 109-119 ◽  
Author(s):  
Chris Stockdale ◽  
Michael Bruno ◽  
Helder Ferreira ◽  
Elisa Garcia-Wilson ◽  
Nicola Wiechens ◽  
...  

In the 30 years since the discovery of the nucleosome, our picture of it has come into sharp focus. The recent high-resolution structures have provided a wealth of insight into the function of the nucleosome, but they are inherently static. Our current knowledge of how nucleosomes can be reconfigured dynamically is at a much earlier stage. Here, recent advances in the understanding of chromatin structure and dynamics are highlighted. The ways in which different modes of nucleosome reconfiguration are likely to influence each other are discussed, and some of the factors likely to regulate the dynamic properties of nucleosomes are considered.


2000 ◽  
Vol 10 (1) ◽  
pp. 7-34 ◽  
Author(s):  
Colin Renfrew

The issue of ‘knowability’ in relation to the origins and distribution of the language families of the world is addressed, and recent advances in historical linguistics and molecular genetics reviewed. While the much-debated problem of the validity of the concept of the language ‘macrofamily’ cannot yet be resolved, it is argued that a time depth for the origins of language families greater than the conventional received figure of c. 6000 years may in some cases be appropriate, allowing the possibility of a correlation between language dispersals and demographic processes following the end of the Pleistocene period. The effects of these processes may still be visible in the linguistic ‘spread zones’, here seen as often the result of farming dispersals, contrasting with the linguistic ‘mosaic zones’ whose early origins may sometimes go back to initial colonization episodes during the late Pleistocene period. If further work in historical linguistics as well as in archaeology and molecular genetics upholds these correlations a ‘new synthesis’, whose outlines may already be discerned, is likely to emerge. This would have important consequences for prehistoric archaeology, and would be of interest also to historical linguists and molecular geneticists. If, however, the proposed recognition of such patterning proves illusory the prospects for ‘knowability’ appear to be less favourable.


Author(s):  
Leif Schauser ◽  
Leszek Boron ◽  
Eloisa Pajuelo ◽  
Thomas Thykjær ◽  
Dorthe Danielsen ◽  
...  

2021 ◽  

Explore a thorough and up to date overview of the current knowledge, developments and outstanding challenges in turbulent combustion and application. The balance among various renewable and combustion technologies are surveyed, and numerical and experimental tools are discussed along with recent advances. Covers combustion of gaseous, liquid and solid fuels and subsonic and supersonic flows. This detailed insight into the turbulence-combustion coupling with turbulence and other physical aspects, shared by a number of the world leading experts in the field, makes this an excellent reference for graduate students, researchers and practitioners in the field.


2008 ◽  
Vol 49 (1) ◽  
pp. 93-99 ◽  
Author(s):  
Andrzej Ciechanowicz ◽  
Andrzej Brodkiewicz ◽  
Agnieszka Bińczak-Kuleta ◽  
Miłosz Parczewski ◽  
Stanisław Czekalski

1990 ◽  
Vol 11 (5-6) ◽  
pp. 388-390 ◽  
Author(s):  
D. A. Knecht ◽  
R. H. Kessin

Physiology ◽  
1994 ◽  
Vol 9 (6) ◽  
pp. 246-251
Author(s):  
AF Dominiczak ◽  
K Lindpaintner

Recent advances in molecular genetics have made it possible to approach the study of complex polygenic multifactorial diseases such as hypertension. Two major approaches, the candidate gene and genetic mapping, have been used to investigate models of genetic hypertension in the rat.


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