The inheritance of responses to schistosomiasis mansoni in two pairs of inbred strains of mice

Parasitology ◽  
1985 ◽  
Vol 90 (2) ◽  
pp. 289-300 ◽  
Author(s):  
Janet T. Jones ◽  
J. R. Kusel
Keyword(s):  
Antibody Response ◽  
Parental Strain ◽  
Genetic Factors ◽  
Single Gene ◽  
Inbred Strains ◽  
Bimodal Distribution ◽  
Immunological Responses ◽  
Schistosomiasis Mansoni ◽  
Inbred Strains Of Mice ◽  
Hybrid Mice

Genetic differences in mice influence both the pathological and immunological responses to schistosomiasis mansoni. We have investigated the nature of the genetic factors influencing these responses by crossing two different pairs of strains of mice which vary in their response to infection, and measuring responses in the F1hybrid and backcross offspring. The two pairs of parental strains differed with respect to faecal egg excretion, accumulation of eggs in the tissues, splenomegaly and pattern of antibody response. The numbers of adult worms which establish do not differ between strains. The inheritance of the responses measured was different in the two pairs of strains. The F1hybrid from the C57BL/6/Ol/a /c cross resembled the low-responding parental strain (CBA/Ca) with respect to faecal egg excretion, accumulation of eggs in the tissues and splenomegaly, and was intermediate in its pattern of antibody response. The F1hybrid mice from the NIH /Ca cross resembled the high-responding strain (CBA/Ca) with respect to faecal egg excretion, accumulation of eggs in the tissues and splenomegaly, and had an earlier and greater antibody response than either parental strain. No evidence of single gene influence on any of these responses was seen in the backcross offspring. The differing patterns of inheritance and the absence of a bimodal distribution of responses in the backcross offspring indicate that each of these responses is influenced by multiple genes. The pattern of antibody response did not correlate between strains with any of the pathological res The positive correlation of egg accumulation in the tissues and faecal egg excretion suggests that there are genetic influences on the fecundity of the worms.

Thyroidal Iodine Metabolism in Inbred and F1 Hybrid Mice

1957 ◽  
Vol 188 (3) ◽  
pp. 499-502 ◽  
Author(s):  
C. K. Chai ◽  
A. Amin ◽  
E. P. Reineke
Keyword(s):  
Inverse Relationship ◽  
Genetic Factors ◽  
Strain Differences ◽  
Inbred Strains ◽  
The Other ◽  
Output Rate ◽  
F1 Hybrid ◽  
Inbred Strains Of Mice ◽  
Iodine Metabolism ◽  
Hybrid Mice

Thyroidal iodine metabolism was studied in four inbred strains of mice and two groups of F1 hybrids by use of radioiodine. Significant strain differences were found in both the 48-hour thyroidal retention of I131 and its output rate constant. Three closely related groups studied were C57BL/6, C57BR/cd and BBF1, their F1 hybrid. The other three groups included A/Jax, BALB/c and CAF1, their F1 hybrid. C57BL/6 mice had a significantly faster output rate and lower 48-hour I131 retention than any other group. The first three groups listed had a more rapid output rate and lower 48-hour retention than the last three. In intergroup comparisons and inverse relationship between I131 output rate and 48-hour retention was clearly shown. The results indicate that in mice pituitary TSH output, as indicated by thyroidal I131 output rate and thyroidal iodine pool size, is controlled by separate genetic factors.

scholarly journals IDENTIFICATION OF AN AUTOSOMAL LOCUS AFFECTING STEROID SULFATASE ACTIVITY AMONG INBRED STRAINS OF MICE

Genetics ◽  
1983 ◽  
Vol 105 (1) ◽  
pp. 181-189
Author(s):  
Robert P Erickson ◽  
Kenneth Harper ◽  
James M Kramer
Keyword(s):  
Recombinant Inbred ◽  
Recombinant Inbred Lines ◽  
Single Gene ◽  
Dehydroepiandrosterone Sulfate ◽  
Inbred Strains ◽  
Inbred Lines ◽  
Steroid Sulfatase ◽  
Steroidal Hormone ◽  
Inbred Strains Of Mice ◽  
Sulfatase Activity

ABSTRACT We have found an activity variant for testicular and liver steroid sulfatase among inbred strains of mice that is not X-linked. C57BL/6J, SM/J and SWR/J testicular extracts hydrolyze 3H-dehydroepiandrosterone sulfate twice as rapidly as do A/J extracts. The C3H/HeJ and DBA/2J strains were intermediate. The Km values for C57BL/6J and A/J are 2.29 ± 0.10 and 1.01 ± 0.02 μM, respectively. The F1 values in both directions were intermediate, which argues against X-linkage of this trait. F2 values show scattered high-intermediate-low values compatible with assay variation superimposed on the segregation of codominant alleles. When assayed for both testicular and liver steroid sulfatase, nine recombinant inbred lines between A/J and C57BL/6J segregate to near the parental strain values. Thus, this activity variation for steroid sulfatase appears to be determined by a single gene, which is not X-linked. Sex and steroidal hormone differences in liver steroid sulfatase activity were not present in the A/J strain, but females of the C57BL/6J and some recombinant inbred lines had higher levels. Electrophoretic studies only disclosed a variant in the SM/J strain, which seems to be secondary to the well-known neuraminidase variation in SM/J.

scholarly journals DISTRIBUTION OF A CROSS-REACTIVE IDIOTYPIC SPECIFICITY IN INBRED STRAINS OF MICE

1973 ◽  
Vol 137 (4) ◽  
pp. 855-869 ◽  
Author(s):  
Laura L. Pawlak ◽  
Alfred Nisonoff
Keyword(s):  
Heavy Chain ◽  
Parental Strain ◽  
Inbred Strains ◽  
The Other ◽  
Congenic Mice ◽  
Congenic Strains ◽  
Inbred Strains Of Mice ◽  
F1 Progeny ◽  
The Cross

The expression of an idiotype characteristic of anti-p-azophenylarsonate antibodies of all A/J mice was explored in F1 progeny, in other inbred strains, and in congenic mice. Of the strains tested only those closely related to A/J produced antibodies with the cross-reactive idiotype (CRI). None of the mice synthesized intermediate levels of CRI. No relationship between H-2 type and idiotype was noted. Congenic mice with a strain A background but a different H-2 type produced CRI in amounts quantitatively equivalent to those of strain A mice. Conversely, the presence of the H-2 genotype of strain A on an unrelated background was not associated with the formation of CRI. Nearly all F1 progeny of strain A mice formed CRI, indicating that failure of the other (non-A) parental strain to produce CRI is not attributable to the presence of a gene controlling the synthesis of a suppressor of CRI. NZB mice, which have the same heavy chain allotype as strain A, but are unrelated in origin, failed to produce CRI, although allotype has been shown to be linked to idiotype in congenic strains.

scholarly journals Genetic variation in β-adrenergic receptors in mice: A magnesium effect determined by a single gene

1983 ◽  
Vol 42 (2) ◽  
pp. 159-168 ◽  
Author(s):  
Jasna Markovac ◽  
Robert P. Erickson
Keyword(s):  
Genetic Variation ◽  
Recombinant Inbred ◽  
Adrenergic Receptors ◽  
Recombinant Inbred Lines ◽  
Single Gene ◽  
Inbred Strains ◽  
Inbred Lines ◽  
Inbred Strains Of Mice ◽  
Potent Antagonist ◽  
Β Adrenergic Receptors

SUMMARYGenetic variation in the amount of binding of dihydroalprenolol (a potent antagonist) to hepatocyte β-adrenergic receptors has been observed among inbred strains of mice. This variation is attributed to a differential effect of magnesium on the receptors between the high and low binding strains. Evidence for a single gene controlling the magnesium effect on dihydroalprenolol binding to β-adrenergic receptors was found using recombinant inbred lines between the high and low strains. We suggest the provisional gene symbol Badm.

III.—Genetics of Gametes. III. Strain Differences in Spermatozoa from Eight Inbred Strains of Mice

1961 ◽  
Vol 68 (1) ◽  
pp. 25-53 ◽  
Author(s):  
R. A. Beatty ◽  
K. N. Sharma
Keyword(s):  
Genetic Factors ◽  
Strain Differences ◽  
Inbred Strains ◽  
Genetic Effects ◽  
Inbred Strains Of Mice ◽  
Hereditary Factors

SynopsisIn animals, the expression of genetic factors has been studied mainly after fertilization, in the embryo or the adult. The study of genetic effects on the gametes themselves has been called the genetics of gametes. As evidence of such genetic effects on gametes, numerous differences have been found in the characteristics of spermatozoa from eight inbred strains of mice. The spermatozoan characteristics studied are mainly dimensional, but also relate to the physiological maturation of spermatozoa and possibly to semen fertility. The dimensional characteristics of spermatozoa are insulated, to an unusual degree, from the effects of environmental and other factors. The genetics of gametes can be regarded as the study of the genetics of the carriers of genes from one generation to the next; this has relevance to general genetics, and also to experiments for controlling the transmission of hereditary factors from parent to offspring.

scholarly journals ANTIBODY RESPONSE TO HOMOGRAFTS

1963 ◽  
Vol 117 (4) ◽  
pp. 675-690 ◽  
Author(s):  
Paul I. Terasaki ◽  
John D. McClelland
Keyword(s):  
Lymph Node ◽  
Antibody Response ◽  
Inbred Strains ◽  
Antibody Activity ◽  
Cytotoxicity Test ◽  
Inbred Strains Of Mice ◽  
Lymphocyte Cytotoxicity ◽  
Lymph Node Cells ◽  
Equivalent Reduction ◽  
Close Parallel

Antigenic differences between certain inbred strains of mice which could not be revealed by hemagglutination techniques were readily disclosed by lymphocyte cytotoxicity. With an improved cytotoxicity test lymphotoxic titers were as high as 1:512 with non-hemagglutinating A anti CBA antisera. In other mouse strain combinations, a close parallel of both types of antibody activity was obtained. Though both activities were absorbed from antisera proportionally by erythrocytes and lymph node cells, 100 to 1000 times as many erythrocytes as lymphocytes were necessary to produce an equivalent reduction in antibody activity. These findings suggest that erythrocytes may possess only subthreshold quantities of certain antigens which are present in readily detectable levels on lymphocytes. Lymphocyte cytotoxicity therefore may assay a wider range of allogenic antigens than hemagglutination.

scholarly journals The major histocompatibility complex-restricted response of recombinant inbred strains of mice to natural tick transmission of Borrelia burgdorferi.

1993 ◽  
Vol 177 (1) ◽  
pp. 9-17 ◽  
Author(s):  
W T Golde ◽  
T R Burkot ◽  
S Sviat ◽  
M G Keen ◽  
L W Mayer ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Borrelia Burgdorferi ◽  
Antibody Response ◽  
Recombinant Inbred ◽  
Inbred Strains ◽  
Recombinant Inbred Strains ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Inbred Strains Of Mice ◽  
Bacterial Antigens

The causative agent of Lyme disease, Borrelia burgdorferi, is transmitted by ticks of the Ixodes ricinus complex. In this study, we report the antibody response of recombinant inbred strains of mice of the H-2, b, d, and k haplotypes, infected with B. burgdorferi as a result of exposure to infected I. dammini. The patterns of antibody response assayed by Western blot analysis indicate significant major histocompatibility complex (MHC) restriction to bacterial antigens within the first 2 mo of infection in mice. Other bacterial antigens induce a significant response across the MHC haplotypes tested when assayed on the same bacterial strain used to transmit the infection, but do not crossreact with the same proteins derived from heterologous strains of B. burgdorferi. No response to outer surface protein A was detected at any time during the 60-d period we analyzed this infection. A third group of bacterial antigens appear to generate a MHC-nonrestricted response, and this lack of restriction is maintained when assaying the crossreactivity of the response with other strains of B. burgdorferi. These proteins may provide more accurate diagnostic probes than those currently in use. Finally, there appears to be a significant difference in the expression of most bacterial antigens when the spirochete is cultured for many passages since the same strain of bacterium isolated from low-passage and high-passage preparations exhibit different banding patterns in Western blots when assayed with the same sera.

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