Resistance of glucose-6-phosphate dehydrogenase deficiency to malaria: effects of fava bean hydroxypyrimidine glucosides onPlasmodium falciparumgrowth in culture and on the phagocytosis of infected cells

Parasitology ◽  
1996 ◽  
Vol 113 (1) ◽  
pp. 7-18 ◽  
Author(s):  
H. Ginsburg ◽  
H. Atamna ◽  
G. Shalmiev ◽  
J. Kanaani ◽  
M. Krugliak
Keyword(s):  
Dehydrogenase Deficiency ◽  
Dietary Habits ◽  
Phagocytic Cells ◽  
Balanced Polymorphism ◽  
Fava Bean ◽  
Infected Cells ◽  
Fava Beans ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Hydrolysis Of ◽  
Selection Of

SUMMARYThe balanced polymorphism of glucose-6-phosphate dehydrogenase deficiency (G6PD-) is believed to have evolved through the selective pressure of malaria combined with consumption of fava beans. The implicated fava bean constituents are the hydroxypyrimidine glucosides vicine and convicine, which upon hydrolysis of their β-O-glucosidic bond, become potent pro-oxidants. In this work we show that the glucosides inhibit the growth ofPlasmodium falciparum, increase the hexose-monophosphate shunt activity and the phagocytosis of malaria-infected erythrocytes. These activities are exacerbated in the presence of β-glucosidase, implicating their pro-oxidant aglycones in the toxic effect, and are more pronounced in infected G6PD-erythrocytes. These results suggest that G6PD-infected erythrocytes are more susceptible to phagocytic cells, and that fava bean pro-oxidants are more efficiently suppressing parasite propagation in G6PD-erythrocytes, either by directly affecting parasite growth, or by means of enhanced phagocytic elimination of infected cells. The present findings could account for the relative resistance of G6PD-bearers to falciparum malaria, and establish a link between dietary habits and malaria in the selection of the G6PD-genotype.

scholarly journals Fava bean–induced hemolytic crisis in glucose-6-phosphate dehydrogenase deficiency

2016 ◽  
Vol 43 (6) ◽  
pp. 230
Author(s):  
IPG Karyana ◽  
IB Mudita
Keyword(s):  
G6pd Deficiency ◽  
Dehydrogenase Deficiency ◽  
Fava Bean ◽  
Hemolytic Crisis ◽  
Fava Beans ◽  
Glucose 6 Phosphate Dehydrogenase

This paper reports a case of hemolytic crisis dueto fava beans in a child with G6PD deficiency.

scholarly journals Glucose-6-phosphate dehydrogenase deficiency enhances enterovirus 71 infection

2008 ◽  
Vol 89 (9) ◽  
pp. 2080-2089 ◽  
Author(s):  
Hung-Yao Ho ◽  
Mei-Ling Cheng ◽  
Shiue-Fen Weng ◽  
Lo Chang ◽  
Tsun-Tsun Yeh ◽  
...  
Keyword(s):  
Dehydrogenase Deficiency ◽  
Enterovirus 71 ◽  
Redox Balance ◽  
Redox Status ◽  
Cellular Redox ◽  
Enteroviral Infection ◽  
Viral Progeny ◽  
Infected Cells ◽  
Exogenous Expression ◽  
Glucose 6 Phosphate Dehydrogenase

Variations in the cellular microenvironment affect the host's susceptibility to pathogens. Using glucose-6-phosphate dehydrogenase (G6PD)-deficient fibroblasts as a model, this study demonstrated that the cellular redox status affects infectivity as well as the outcome of enterovirus 71 (EV71) infection. Compared with their normal counterparts, G6PD-deficient cells supported EV71 replication more efficiently and showed greater cytopathic effect and loss of viability. Mechanistically, viral infection led to increased oxidative stress, as indicated by increased dichlorofluorescein fluorescence and a diminished ratio of glutathione (GSH) to its disulfide form (GSSG), with the effect being greater in G6PD-deficient cells. Exogenous expression of active G6PD in the deficient cells, which increased the intracellular GSH : GSSG ratio, suppressed the generation of viral progeny. Consistent with this, treatment with N-acetylcysteine offered resistance to EV71 propagation and a cytoprotective effect on the infected cells. These findings support the notion that G6PD status, and thus redox balance, is an important determinant of enteroviral infection.

scholarly journals Glucose-6-Phosphate Dehydrogenase Deficiency in Greece

Blood ◽  
1961 ◽  
Vol 18 (1) ◽  
pp. 34-47 ◽  
Author(s):  
LEDA ZANNOS-MARIOLEA ◽  
CHRISTOS KATTAMIS
Keyword(s):  
Individual Differences ◽  
Dehydrogenase Deficiency ◽  
Normal Limit ◽  
Red Cells ◽  
Female Patients ◽  
Male Patients ◽  
Stability Method ◽  
Fava Beans ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Genetic Hypothesis

Abstract The glutathione stability of red cells was estimated in 40 patients during acute hemolysis induced by fava beans. There were wide individual differences but in all cases except one (Case 18) the post-incubation GSH fell to levels below 40 mg. per cent packed RBC which is the lower normal limit. The GSH stability on 44 mothers and 37 fathers gave results consistent with the genetic hypothesis that in male patients the mother is the carrier of the biochemical defect, while in female patients both parents are carriers, since, as a rule, only female homozygotes suffer from hemolytic episodes. However, in only 77.7 per cent of the mothers could the biochemical defect be proved by this method. The Motulsky test was performed in 30 of the 40 patients. It gave abnormal decolorization times in 25 or 83 per cent of the cases. This test is therefore valuable for diagnosing "sensitivity" during a hemolytic episode; it is, nevertheless, less sensitive than the GSH stability method. The Motulsky test was also performed on 31 mothers, 18 fathers and 8 siblings. It proved to be unreliable in the detection of female heterozygotes. G-6-PD deficiency is widely disseminated in Greece; it is, however, not evenly distributed throughout the country. The highest frequency of G-6-PD deficiency found so far in males was about 3 per cent; the lowest was 0.7 per cent.

scholarly journals Glucose-6-phosphate Dehydrogenase Deficiency: A Case Report

2017 ◽  
Vol 12 (1) ◽  
pp. 47-49
Author(s):  
Md Kamrul Hassan ◽  
Aloke Kumar Saha ◽  
Lakshman Chandra Kundu ◽  
Poly Begum ◽  
Abu Yousuf
Keyword(s):  
G6pd Deficiency ◽  
Neonatal Jaundice ◽  
Dehydrogenase Deficiency ◽  
Cultural Factors ◽  
Enzyme Defect ◽  
Asian Populations ◽  
Hemolytic Crisis ◽  
Life Threatening ◽  
Fava Beans ◽  
Glucose 6 Phosphate Dehydrogenase

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common hereditary enzyme disorder and more than 200 million people have a deficiency in this enzyme. G6PD deficiency is an X-linked enzyme defect, and one of its main signs is the presence of hemolytic anemia. It is a worldwide important cause of neonatal jaundice and causes life threatening hemolytic crisis in childhood. At later ages, certain drugs such as anti-malarial drugs and fava beans cause hemolysis among G6PD deficiency patients. The frequency and severity is influenced by genetic and cultural factors. It is common in Mediterranean, African and some East Asian populations but rare in Bangladeshi peoples. Genetic counseling may be of benefit for patients and their families. Other treatment is symptomatic and supportive.Faridpur Med. Coll. J. Jan 2017;12(1): 47-49

Clinical Manifestations and Therapeutic Findings of the Children with Glucose-6-Phosphate Dehydrogenase Deficiency Presenting Favism

2020 ◽  
Vol 20 ◽  
Author(s):  
Fariba Tarhani ◽  
Alireza Nezami ◽  
Ghobad Heidari ◽  
Babak Abdolkarimi
Keyword(s):  
G6pd Deficiency ◽  
Dehydrogenase Deficiency ◽  
Clinical Manifestations ◽  
Descriptive Study ◽  
Cross Sectional ◽  
Common Complaint ◽  
The Mean ◽  
Fava Beans ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Hydration Therapy

Aim: Favism is characterized as acute anemia, due to Glucose-6-phosphate dehydrogenase (G6PD) deficiency as a result of fava beans intake. It is associated with paleness, jaundice, and hemoglobinuria. In this study, signs, symptoms and therapeutic findings of the patients with hemolysis due to G6PD deficiency were investigated in Shahid Madani Hospital of Khorramabad, Lorestan. Methods: This is a single-center cross-sectional descriptive study that was conducted on all children with G6PD deficiencyinduced hemolysis. Results: 308 children (64.3% male and 35.7% female) were included in this study. The most common complaint was jaundice (82.5%) and the most common cause of hemolysis was the intake of fava bean (85.7%). 68% of the children were treated with hydration/fluid therapy. Blood transfusion was conducted in 36.36% of the cases and the mean of blood administered was 18.9 cc/kg. Conclusion: In this study, hydration therapy was performed in most of the children presenting favism. Also, the incorrect calculation of the amount of blood needed for transfusion has increased the frequency of blood transfusions and prolonged hospitalization time.

Automated Fluorometric Method for Screening for Erythrocyte Glucose-6-Phosphate Dehydrogenase Deficiency

1973 ◽  
Vol 19 (3) ◽  
pp. 301-303 ◽  
Author(s):  
Larry G Dickson ◽  
Carl B Johnson ◽  
Donald R Johnson
Keyword(s):  
Whole Blood ◽  
Dehydrogenase Deficiency ◽  
Fluorometric Method ◽  
Fava Bean ◽  
Erythrocyte Enzyme ◽  
Glucose 6 Phosphate Dehydrogenase

Abstract Deficiency of the erythrocyte enzyme, glucose-6-phosphate dehydrogenase [EC 1.1.1.49, GPD] is associated with hemolysis after exposure to oxidative drugs, ingestion of the fava bean, or infection. Episodes of hemolysis may be prevented by avoiding ingestion of substances toxic to erythrocytes with GPD deficiency. We describe here an automated fluorometric method suitable for screening for erythrocyte GPD deficiency. Anticoagulated whole blood is examined. Reliable results are obtained for hemoglobin concentrations ranging from 7-17 g/100 ml.

Erythrocytic Glucose-6-Phosphate Dehydrogenase Deficiency as a Problem in the Selection of Blood Donors

Vox Sanguinis ◽  
1963 ◽  
Vol 8 (1) ◽  
pp. 47-50
Author(s):  
A. Tizianello ◽  
I. Pannacciulli ◽  
E. Salvidio ◽  
A. Gay
Keyword(s):  
Blood Donors ◽  
Dehydrogenase Deficiency ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Selection Of

Unsuspected glucose-6-phosphate dehydrogenase deficiency presenting as symptomatic methemoglobinemia with severe hemolysis after fava bean ingestion in a 6-year-old boy

2011 ◽  
Vol 93 (5) ◽  
pp. 664-666 ◽  
Author(s):  
Marie-Hélène Odièvre ◽  
Névéna Danékova ◽  
Bettina Mesples ◽  
Myriam Chemouny ◽  
Nathalie Couque ◽  
...  
Keyword(s):  
Dehydrogenase Deficiency ◽  
Fava Bean ◽  
Glucose 6 Phosphate Dehydrogenase

ERRATUM

PEDIATRICS ◽  
1990 ◽  
Vol 85 (5) ◽  
pp. 847-847
Keyword(s):  
Nalidixic Acid ◽  
Dehydrogenase Deficiency ◽  
Fava Beans ◽  
Glucose 6 Phosphate Dehydrogenase

The reported sign or symptom after the drug "Nalidixic Acid" (Table 6, page 928 of the November, 1989, issue of Pediatrics) and after the agent "Fava beans" (Table 7, page 930 of the same issue) should read: "Hemolysis in patient with glucose-6-phosphate dehydrogenase deficiency (G-6-PD)." Pediatrics thanks Dr R. Alan Brinson of Tupelo, MS, for calling attention to this error.

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